Raf meets Ras: completing the framework of a signal transduction pathway
Abstract
The Ras oncoprotein, a GTP-activated molecular switch, interacts directly with the Raf oncoprotein to recruit the MAP kinases and their subordinates. In this way, a mitogenic signal initiated by tyrosine kinases is converted by Ras into a wave of regulatory phosphorylation on serine and threonine residues that, depending on its intensity and duration, and the variety of substrates available, results in cell differentiation or cell division.
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RAF-1 is a serine/threonine protein kinase that acts as a regulatory link between membrane-associated Ras GTPases and the Ras-Raf-MEK-Erk MAPK pathway.
“Rapidly accelerated fibrosarcoma 1 (RAF-1, also known as c-Raf) is a serine/threonine protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the Ras-Raf-MEK-Erk mitogen activated protein kinase (MAPK) pathway.”
From Structural basis of microtubule-mediated signal transduction (2026) · cites this paper as [92]
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Structural basis of microtubule-mediated signal transduction
Choi, S. R., Blum, T. B., Giono, M., Roy, B., Vakonakis, I., Schmid, D., Oelgarth, N., Ranganathan, A., Gossert, A. D., Shivashankar, G. V., et al. (2026) · Cell · doi:10.1016/j.cell.2025.11.011 · Cited by 14 · see citing works
- Authors
- Avruch, J., Zhang, X.-F., & Kyriakis, J. M.
- Affiliations
- Massachusetts General Hospital (US)
- Harvard University (US)
- ORCID
- Avruch, Joseph
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 19
- Issue
- 7
- Pages
- 279-283
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1971977518
- Cited by
- 577
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 10
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- Raf, Ras, MAPK signaling, signal transduction, tyrosine kinase signaling, serine/threonine phosphorylation, cell proliferation, cell differentiation
- MeSH terms
- Amino Acid Sequence, Animals, Enzyme Activation, Humans, Molecular Sequence Data, Proto-Oncogene Proteins, Signal Transduction, Oncogene Protein p21(ras), Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-raf
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