The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.
Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica
Abstract
We explored the role of interleukin 1 (IL-1) in two models of pulmonary fibrosis (PF), elicited in mice by the intra-tracheal instillation of bleomycin or silica. In both models, administration of IL-1 receptor antagonist (IL-1ra) by an osmotic minipump implanted i.p., at a rate of 0.5 microgram/h, completely prevented the collagen deposition, as evaluated by the lung hydroxyproline content on day 15 after instillation. IL-1ra had little or no influence on the number of cells recovered from the broncho-alveolar lavage. Study of histological sections suggests that IL-1ra globally decreased the proportion of damaged lung and particularly in silica the formation of nodules with a rich content in collagen fibrils. IL-1ra was also effective in reducing the lung hydroxyproline content when given on day 25 after instillation of bleomycin or silica, indicating that it may reverse established PF. This study indicates that IL-1ra might be useful for the treatment of incipient or established pulmonary fibrosis.
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“Moreover, in a mouse model of bleomycin-or silica-induced pulmonary fibrosis, treatment with IL-1 receptor antagonist (IL-1ra) reduces the proportion of damaged lung (25).”
From Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica (2008) · cites this paper as [25]
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Cites
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Self-citationInterleukin-1 receptor antagonist reduces mortality from endotoxin shock
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Self-citationInterleukin 1, a potential regulator of fibroblast proliferation.
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Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro
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Self-citationFibrogenic cytokines: the role of immune mediators in the development of scar tissue
Kovacs, E. J. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90107-5 · Cited by 585
Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.
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Research works printed but not linked: 1
- Thrall, 1979, Bleomycin-induced pulmonary fibrosis in the rat, Am J Pathol, 95, 117
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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment: International Consensus Statement
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.2.ats3-00 · Cited by 2,651
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, R. J., Burdick, M. D., Hong, K. M., Lutz, M., Murray, L. A., Xue, Y., Belperio, J. A., Keane, M. P., & Strieter, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20997 · Cited by 1,071
Ortiz, L. A., DuTreil, M., Fattman, C., Pandey, A. C., Torres, G., Go, K., & Phinney, D. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704421104 · Cited by 1,019
Moeller, A., Ask, K., Warburton, D., Gauldie, J., & Kolb, M. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.08.011 · Cited by 1,007
Metadata
- Authors
- Piguet, P. F., Vesin, C., Grau, G. E., & Thompson, R. C.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Piguet, Pierre F.
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 1993-01
- Volume
- 5
- Issue
- 1
- Pages
- 57-61
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2001796665
- Cited by
- 215
- References
- 24
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 10
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- interleukin-1 receptor antagonist, pulmonary fibrosis, bleomycin-induced lung injury, silica-induced lung injury, interleukin-1, collagen deposition, hydroxyproline, lung hydroxyproline, pulmonary nodules, bronchoalveolar lavage, anti-inflammatory therapy
- MeSH terms
- Animals, Bleomycin, Bronchoalveolar Lavage Fluid, Hydroxyproline, Interleukin-1, Lung, Mice, Inbred CBA, Mice, Inbred C57BL, Pulmonary Fibrosis, RNA, Messenger, Silicon Dioxide, Tumor Necrosis Factor-alpha, Receptors, Interleukin-1, Mice
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