Cited by 215Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational and environmental lung diseasesTransplantation: Methods and Outcomes

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Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica

Piguet, Pierre F., Vesin, Christian, Grau, Georges E., Thompson, Robert C.·1993·Cytokine

DOI 10.1016/1043-4666(93)90024-y

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Abstract

We explored the role of interleukin 1 (IL-1) in two models of pulmonary fibrosis (PF), elicited in mice by the intra-tracheal instillation of bleomycin or silica. In both models, administration of IL-1 receptor antagonist (IL-1ra) by an osmotic minipump implanted i.p., at a rate of 0.5 microgram/h, completely prevented the collagen deposition, as evaluated by the lung hydroxyproline content on day 15 after instillation. IL-1ra had little or no influence on the number of cells recovered from the broncho-alveolar lavage. Study of histological sections suggests that IL-1ra globally decreased the proportion of damaged lung and particularly in silica the formation of nodules with a rich content in collagen fibrils. IL-1ra was also effective in reducing the lung hydroxyproline content when given on day 25 after instillation of bleomycin or silica, indicating that it may reverse established PF. This study indicates that IL-1ra might be useful for the treatment of incipient or established pulmonary fibrosis.

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The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid
Woessner, J. F. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90291-0 · Cited by 3,849
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
Eisenberg, S. P., Evans, R. J., Arend, W. P., Verderber, E. L., Brewer, M. T., Hannum, C. H., & Thompson, R. C. (1990) · Nature · doi:10.1038/343341a0 · Cited by 1,084
Self-citation
Interleukin-1 receptor antagonist reduces mortality from endotoxin shock
OHLSSON, K., Björk, P., Bergenfeldt, M., Hageman, R. J. J., & Thompson, R. C. (1990) · Nature · doi:10.1038/348550a0 · Cited by 848
Self-citation
Interleukin 1, a potential regulator of fibroblast proliferation.
Schmidt, J. A., Mizel, S. B., Cohen, D. A., & Green, I. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.128.5.2177 · Cited by 830
Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1
Philip, R., & Epstein, L. B. (1986) · Nature · doi:10.1038/323086a0 · Cited by 762
Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro
Dinarello, C. A., & Thompson, R. C. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90142-g · Cited by 719
Self-citation
Fibrogenic cytokines: the role of immune mediators in the development of scar tissue
Kovacs, E. J. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90107-5 · Cited by 585
Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.
Piguet, P. F., Collart, M. A., Grau, G. E., Kapançi, Y., & VASSALLI, P. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.3.655 · Cited by 583
Self-citation
Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.
Collart, M. A., Belin, D., Vassalli, J. D., Kossodo, S. D., & VASSALLI, P. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.164.6.2113 · Cited by 524
Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation
Khalil, N., Bereznay, O., Sporn, M., & Greenberg, A. H. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.3.727 · Cited by 505

Show all 24 references

Research works printed but not linked: 1

Thrall, 1979, Bleomycin-induced pulmonary fibrosis in the rat, Am J Pathol, 95, 117

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Korthagen, N. M., van Moorsel, C. H. M., Kazemier, K. M., Ruven, H. J. T., & Grutters, J. C. (2012) · Immunogenetics · doi:10.1007/s00251-012-0604-6 · Cited by 71
Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study
Rodrı́guez-Reyna, T. S., Furuzawa‐Carballeda, J., Cabiedes, J., Hermosillo, L. D. F., Martínez-Reyes, C., Díaz‐Zamudio, M., & Llorente, L. (2011) · Rheumatology International · doi:10.1007/s00296-011-2056-y · Cited by 66
Skin Score Decrease in Systemic Sclerosis Patients Treated with Intravenous Immunoglobulin - A Preliminary Report
Levy, Y. M., Sherer, Y., Langevitz, P., Lorber, M., Rotman, P., Fabbrizzi, F., & Shoenfeld, Y. (2000) · Clinical Rheumatology · doi:10.1007/s100670050158 · Cited by 66
How Frustration Leads to Inflammation
O'Neill, L. A. J. (2008) · Science · doi:10.1126/science.1158398 · Cited by 62
Intercellular Adhesion Molecule-1 and L-Selectin Regulate Bleomycin-Induced Lung Fibrosis
Hamaguchi, Y., Nishizawa, Y., Yasui, M., Hasegawa, M., Kaburagi, Y., Komura, K., Nagaoka, T., Saito, E., Shimada, Y., Takehara, K., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64439-2 · Cited by 58
Cytokine regulation of proteoglycan production in fibroblasts: separate and synergistic effects
Tiedemann, K., Malmström, A., & Westergren‐Thorsson, G. (1997) · Matrix Biology · doi:10.1016/s0945-053x(97)90020-2 · Cited by 58
Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues
Yu, H., Ko, E. C., Chang, C., Yuan, K. S., Wu, A. T. H., Shan, Y., & Wu, S. (2018) · Marine Drugs · doi:10.3390/md16100392 · Cited by 57
Genetic Risk Factors for Idiopathic Pulmonary Fibrosis: Insights into Immunopathogenesis
Michalski, J. E., & Schwartz, D. A. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s280958 · Cited by 61
Mucosal Tumor Necrosis Factor-α Production and Extensive Disruption of Sulfated Glycosaminoglycans Begin within Hours of Birth in Neonatal Respiratory Distress Syndrome
MURCH, S. H., Costeloe, K., Klein, N. J., Rees, H. C., McIntosh, N., Keeling, J. W., & MacDonald, T. T. (1996) · Pediatric Research · doi:10.1203/00006450-199609000-00019 · Cited by 56
FTS reduces bleomycin-induced cytokine and chemokine production and inhibits pulmonary fibrosis in mice
Yara, S., Kawakami, K., Kudeken, N., Tohyama, M., Teruya, K., Chinen, T., Awaya, A., & Saitô, A. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01493.x · Cited by 55
Ferulic acid ameliorates the progression of pulmonary fibrosis via inhibition of TGF-β/smad signalling
Ali, S. A., Saifi, M. A., Pulivendala, G., Godugu, C., & Talla, V. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.111980 · Cited by 53
NLRP inflammasome as a key role player in the pathogenesis of environmental toxicants
Moloudizargari, M., Moradkhani, F., Asghari, N., Fallah, M., Asghari, M. H., Moghadamnia, A. A., & Abdollahi, M. R. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116585 · Cited by 53
Essential role of ROS-mediated NFAT activation in TNF-α induction by crystalline silica exposure
Ke, Q., Li, J., Ding, J., Ding, M., Wang, L., Liu, B., Costa, M., & Huang, C. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00007.2006 · Cited by 51
The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice
Tanaka, Y., Ishitsuka, Y., Hayasaka, M., Yamada, Y., Miyata, K., Endo, M., Kondo, Y., Moriuchi, H., Irikura, M., Tanaka, K., et al. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.004 · Cited by 51
Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs
Cavarra, E., Carraro, F., Fineschi, S., Naldini, A., Bartalesi, B., Pucci, A., & Lungarella, G. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00170.2004 · Cited by 52
Genetic susceptibility in pneumoconiosis
Yücesoy, B., & Luster, M. I. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.10.021 · Cited by 50
IL-1beta differently involved in IL-8 and FGF-2 release in crystalline silica-treated lung cell co-cultures
Herseth, J. I., Volden, V., Schwarze, P. E., Låg, M., & Refsnes, M. (2008) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-5-16 · Cited by 50
Immunoinflammatory responses and fibrogenesis
Azouz, A., Razzaque, M. S., El-Hallak, M., & Taguchi, T. (2004) · Medical Molecular Morphology · doi:10.1007/s00795-004-0255-2 · Cited by 50
C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice
Murakami, S., Nagaya, N., Itoh, T., Fujii, T., Iwase, T., Hamada, K., Kimura, H., & Kangawa, K. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00087.2004 · Cited by 48
Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury
Failla, M., Genovese, T., Mazzon, E., Gili, E., Muià, C., Sortino, M. A., Crimi, N., Caputi, A. P., Cuzzocrea, S., & Vancheri, C. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-137 · Cited by 48
Role of interleukin-1 in mesangial cell proliferation and matrix deposition in experimental mesangioproliferative nephritis.
Tesch, G. H., Lan, H. Y., Atkins, R. C., & Nikolic‐Paterson, D. J. (1997) · Europe PMC (PubMed Central) · Cited by 47
Silica Induces Macrophage Cytokines through Phosphatidylcholine-Specific Phospholipase C with Hydrogen Peroxide
Liu, H., Zhang, H., & Forman, H. J. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0297oc · Cited by 46
Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages
Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B., & Scott, C. J. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0129-5 · Cited by 43
Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicosis
Zhai, R., Ge, X.-M., Li, H., Tang, Z., Liao, R., & Kleinjans, J. C. S. (2004) · American Journal of Industrial Medicine · doi:10.1002/ajim.20051 · Cited by 44
N-acetylcysteine inhibits TNF-alpha, sTNFR, and TGF-beta1 release by alveolar macrophages in idiopathic pulmonary fibrosis in vitro.
Cu, A., Ye, Q., Sarrı́a, R., Nakamura, S., Guzman, J., & Costabel, U. (2009) · Sarcoidosis vasculitis and diffuse lung diseases · Cited by 43
Potential Therapeutic Initiatives for Fibrogenic Lung Diseases
Goldstein, R. H., & Fine, A. (1995) · CHEST Journal · doi:10.1378/chest.108.3.848 · Cited by 44
The pathogenesis of cutaneous fibrosis
Liu, B., & Connolly, M. K. (1998) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/s1085-5629(98)80055-2 · Cited by 44
Pulmonary platelet trapping induced by bleomycin: correlation with fibrosis and involvement of the beta 2 integrins.
Piguet, P. F., & Vesin, C. (1994) · Europe PMC (PubMed Central) · Cited by 42
Self-citation
Therapeutic modulation of cytokines.
Henderson, B. E. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.6.519 · Cited by 41
Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation
Lee, J., Choi, I.-S., Park, K.-O., Lee, J.-H., Park, S., Park, C., & Jang, A. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2129-9 · Cited by 41

Authors: Piguet, P. F., Vesin, C., Grau, G. E., & Thompson, R. C.
Affiliations: University of Geneva (CH)
Corresponding author: Piguet, Pierre F.
ORCID: Grau, Georges E.
Thompson, Robert C.
Venue: Cytokine
Publisher: Elsevier BV
Published: 1993-01
Volume: 5
Issue: 1
Pages: 57-61
ISSN: 1043-4666 (ISSN-L)
DOI: 10.1016/1043-4666(93)90024-y
OpenAlex: W2001796665
Cited by: 215
References: 24
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 10
FWCI: 10.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine (publishedVersion)
PubMed (publishedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords: interleukin-1 receptor antagonist, pulmonary fibrosis, bleomycin-induced lung injury, silica-induced lung injury, interleukin-1, collagen deposition, hydroxyproline, lung hydroxyproline, pulmonary nodules, bronchoalveolar lavage, anti-inflammatory therapy
MeSH terms: Animals, Bleomycin, Bronchoalveolar Lavage Fluid, Hydroxyproline, Interleukin-1, Lung, Mice, Inbred CBA, Mice, Inbred C57BL, Pulmonary Fibrosis, RNA, Messenger, Silicon Dioxide, Tumor Necrosis Factor-alpha, Receptors, Interleukin-1, Mice

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Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica

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