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A case of giant cell myocarditis with evidence of cardiac autoimmunity
Abstract
A 45-year-old-woman with giant cell myocarditis showing high titer of circulating antiheart antibodies is reported. She experienced two recurrences of myocarditis and repeatedly responded to immunosuppressive therapy using prednisolone. The titer of antiheart antibodies went up and down appropriately according to the clinical responses to immunosuppressive therapy. This case suggested that giant cell myocarditis might be related to autoimmunity.
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Serum antibodies in patients with giant cell myocarditis target heart tissue, indicating the presence of autoantibodies specific to heart antigens.
“Serum antibodies in affected patients targeted the heart tissue, indicating the presence of autoantibodies specific to heart antigens in this condition.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [190]
Autoantibodies and autoreactive T cells targeting the heart play a pathogenic role in giant cell myocarditis.
“Clinical and animal studies highlighted the pathogenic role of autoantibodies and autoreactive T cells targeting the heart in giant cell myocarditis.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [190]
In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions.
“In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions. 15-18,57,189,190,218”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [190]
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Research works printed but not linked: 27
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Cited by
Sorted by citations
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Metadata
- Authors
- Kodama, M., Hanawa, H., Saeki, M., Inomata, T., Suzuki, K., Hirono, S., Tanabe, Y., Izumi, T., Shibata, A., Yamamoto, T., Hirokawa, Y., Masani, F., Kumakura, M., & Higuma, N.
- Affiliations
- Niigata University (JP)
- Niigata Prefectural Shibata Hospital (JP)
- Venue
- Cardiovascular Pathology
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 4
- Issue
- 2
- Pages
- 127-131
- ISSN
- 1054-8807 (ISSN-L)
- OpenAlex
- W2010508454
- Cited by
- 5
- References
- 0
- Citations by year
- 2024: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (05770454, 06770486)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- giant cell myocarditis, cardiac autoimmunity, anti-heart antibodies, serum autoantibodies, immunosuppressive therapy, prednisolone
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