The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate
Open accessAbstract
Anergic self-reactive B cells competing within a polyclonal B cell repertoire fail to migrate into primary follicles and die after 1-3 days residence in T cell zones. Transfer of anergic HEL-specific B cells to recipients lacking HEL autoantigen and continuous bromodeoxyuridine labeling in mixed bone marrow chimeras confirms that follicular exclusion and cell death in 1-3 days is not an intrinsic characteristic of anergic cells but results from competition with B cells bearing other specificities together with continued binding of autoantigen. When naive (nontolerant) HEL-specific B cells were transferred into mice expressing HEL autoantigen, they were also excluded from follicles and their lifespan was dramatically shortened, although they became activated to express CD86 (B7-2/B70). In the presence of helper T cells, activated B cells but not anergic B cells were rescued from death and formed large extrafollicular foci to autoantibody-secreting cells. Antigen-induced exclusion from follicles is therefore an independent process from anergy that prevents self-reactive B cells from recirculating in the long-lived repertoire and may foster interactions with T cells during immune responses. By contrast, anergy prevents self-reactive B cells from collaborating with helper T cells and secreting autoantibody while trapped in the T zone.
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Self-citationInduction of self-tolerance in mature peripheral B lymphocytes
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Self-citationCellular Mechanisms of Immunologic Tolerance
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Cited by
Lymphocyte Homing and Homeostasis
Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846
Thien, M., Phan, T. G., Gardam, S., Amesbury, M., Basten, A., Mackay, F., & Brink, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.010 · Cited by 746
A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements
Hargreaves, D. C., Hyman, P. L., Lu, T. T., Ngo, V. N., Bidgol, A., Suzuki, G., Zou, Y.-R., Littman, D. R., & Cyster, J. G. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.1.45 · Cited by 659
Self-citationOkada, T., Miller, M. J., Parker, I., Krummel, M. F., Neighbors, M., Hartley, S. B., O'Garra, A., Cahalan, M. D., & Cyster, J. G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030150 · Cited by 585
Self-citationFrom T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik, M. J., Craft, J. E., & Mamula, M. J. (2001) · Nature Reviews Immunology · doi:10.1038/35100573 · Cited by 572
Metadata
- Authors
- Cyster, J. G., & Goodnow, C. C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 3
- Issue
- 6
- Pages
- 691-701
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1981525542
- Cited by
- 273
- References
- 38
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cyster, J. G., & Goodnow, C. C. (1995). Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. Immunity. https://doi.org/10.1016/1074-7613(95)90059-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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