Therapeutic Applications of Iminosugars: Current Perspectives and Future Opportunities

Current Developments in the Synthesis and Biological Activity of Aza-C-Nucleosides:Immucillins and Related Compounds

Merino, P., Tejero, T., & Delso, I. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708784049612 · Cited by 31

Carbonoyloxy analogs of the anti-metastatic drug swainsonine

Dennis, J. W., White, S. L., Freer, A. M., & Dime, D. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90112-a · Cited by 30

Mammalian cells contain a second nucleocytoplasmic hexosaminidase

Gutternigg, M., Rendić, D., Grillari‐Voglauer, R., Iskratsch, T., & Wilson, I. B. H. (2008) · Biochemical Journal · doi:10.1042/bj20081630 · Cited by 30

Synthesis and mannosidase inhibitory activity of 6- and 7-substituted analogs of swainsonine

Pearson, W. H., & Hembre, E. J. (2001) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)01778-6 · Cited by 30

Carbamate Analogues of Fumagillin as Potent, Targeted Inhibitors of Methionine Aminopeptidase-2

Arico-Muendel, C. C., Benjamin, D. R., Caiazzo, T., Centrella, P. A., Contonio, B. D., Cook, C. M., Doyle, E., Hannig, G., Labenski, M., Searle, L. L., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm901260k · Cited by 29

α-Galactosylceramide and Novel Synthetic Glycolipids Directly Induce the Innate Host Defense Pathway and Have Direct Activity against Hepatitis B and C Viruses

Mehta, A. S., Gu, B., Conyers, B., Ouzounov, S., Wang, L., Moriarty, R. M., Dwek, R. A., & Block, T. M. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.6.2085-2090.2004 · Cited by 29

Iminosugars as Active‐Site‐Specific Chaperones for the Treatment of Lysosomal Storage Disorders

Fan, J. (2007) · doi:10.1002/9780470517437.ch10 · Cited by 28

Rapid Synthesis of Iminosugar Derivatives for Cell‐Based In Situ Screening: Discovery of “Hit” Compounds with Anticancer Activity

Zhang, L. J., Sun, F., Li, Y., Sun, X. Z., Liu, X., Huang, Y., Zhang, L., Ye, X., & Xiao, J. (2007) · ChemMedChem · doi:10.1002/cmdc.200700120 · Cited by 28

Large scale synthesis of the acetonides of l-glucuronolactone and of l-glucose: easy access to l-sugar chirons

Weymouth‐Wilson, A. C., Clarkson, R. A., Jones, N. A., Best, D., Wilson, F. X., Pino-González, M. S., & Fleet, G. W. J. (2009) · Tetrahedron Letters · doi:10.1016/j.tetlet.2009.08.124 · Cited by 28

Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as α-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies

Bello, C., Cea, M., Bello, G. D., Garuti, A., Rocco, I., Cirmena, G., Morán, E., Nahimana, A., Duchosal, M. A., Fruscione, F., et al. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.03.009 · Cited by 28

Combinatorial Approaches to Iminosugars as Glycosidase and Glycosyltransferase Inhibitors

Gregori, M., Ferla, B. L., & Cipolla, L. (2006) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/138620706778249703 · Cited by 28

Inhibition of the glucosyltransferase activity of clostridial Rho/Ras‐glucosylating toxins by castanospermine

Jank, T., Ziegler, M. O. P., Schulz, G. E., & Aktories, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.05.025 · Cited by 27

Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis

Zhao, Y., Zhou, Y., O’Boyle, K. M., & Murphy, P. V. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.05.012 · Cited by 26

A chemoenzymatic-RCM strategy for the enantioselective synthesis of new dihydroxylated 5-hydroxymethyl-indolizidines and 6-hydroxymethyl-quinolizidines

Lesma, G., Colombo, A., Landoni, N., Sacchetti, A., & Silvani, A. (2007) · Tetrahedron Asymmetry · doi:10.1016/j.tetasy.2007.07.017 · Cited by 24

Effect of alpha3beta1 and alphavbeta3 integrin glycosylation on interaction of melanoma cells with vitronectin.

Janik, M., Przybyło, M., Pocheć, E., Pokrywka, M., & Lityń́ska, A. (2010) · Acta Biochimica Polonica · doi:10.18388/abp.2010_2372 · Cited by 23

Bioinformatics for glycobiology and glycomics : an introduction

von der Lieth, C., Lütteke, T., & Frank, M. (2009) · Wiley-Blackwell eBooks · Cited by 23

Synthesis of (+)-DGDP and (−)-7-epialexine

Donohoe, T. J., Cheeseman, M. D., O’Riordan, T. J. C., & Kershaw, J. A. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b815332a · Cited by 22

De Novo Asymmetric Approach to 8a-epi-Swainsonine

O'Doherty, G. A., Coral, J. A., Guo, H., & Shan, M. (2009) · Heterocycles · doi:10.3987/com-08-s(d)12 · Cited by 22

Structure–activity relationships of azasugar-based MMP/ADAM inhibitors

Moriyama, H., Tsukida, T., Inoue, Y., Kondo, H., Yoshino, K., & Nishimura, S. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00530-4 · Cited by 21

The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases

Ostash, B., Doud, E. H., & Fedorenko, V. (2010) · Biological Chemistry · doi:10.1515/bc.2010.053 · Cited by 20

Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells.

Pacheco, C. D., Elrick, M. J., & Lieberman, A. P. (2009) · Autophagy · doi:10.4161/auto.5.4.8364 · Cited by 20

The Alkylated Imino Sugar, n -( n -Nonyl)-Deoxygalactonojirimycin, Reduces the Amount of Hepatitis B Virus Nucleocapsid in Tissue Culture

Lu, X., Tran, T., Şi̇mşek, E., & Block, T. M. (2003) · Journal of Virology · doi:10.1128/jvi.77.22.11933-11940.2003 · Cited by 19

Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors

Moriyama, H., Tsukida, T., Inoue, Y., Kondo, H., Yoshino, K., & Nishimura, S. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00531-6 · Cited by 19

Calnexin Δ185–520 partially reverses the misprocessing of the ΔF508 cystic fibrosis transmembrane conductance regulator1

Okiyoneda, T., Wada, I., Jono, H., Shuto, T., Yoshitake, K., Nakano, N., Nagayama, S., Harada, K., Isohama, Y., Miyata, T., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03134-4 · Cited by 18

A NEW ANTIBIOTIC R-468 ACTIVE AGAINST DRUG-RESISTANT SHIGELLA.

NISHIKAWA, T., & Ishida, N. (1965) · PubMed · Cited by 17

Inhibitors of Glycoprotein Processing

Elbein, A. D., & Molyneux, R. J. (1998) · doi:10.1002/3527601740.ch11 · Cited by 16

Discovery of Iminosugar Derivatives with Strong IFN‐γ Inducing Activity

Zhang, L. J., Sun, F., Wang, Q., Zhou, J., Zhang, L., Zhang, X., & Ye, X. (2009) · ChemMedChem · doi:10.1002/cmdc.200900027 · Cited by 15

Biological study of the Angiogenesis Inhibitor N‐(8‐(3‐ethynylphenoxy)octyl‐1‐deoxynojirimycin

Zhao, Y., Zhou, Y., Boyle, K. M. O., & Murphy, P. V. (2010) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2010.00968.x · Cited by 14

Miglustat

Sorbera, L. A., Castañer, J., & Bayés, M. (2003) · Drugs of the Future · doi:10.1358/dof.2003.028.03.723080 · Cited by 13

Targeting Plasmodium Falciparum Purine Salvage Enzymes: A Look At Structure-Based Drug Development

Donaldson, T. M., & Kim, K. (2010) · Infectious Disorders - Drug Targets · doi:10.2174/187152610791163408 · Cited by 12

General Strategies for the Synthesis of Iminosugars and New Approaches Towards Iminosugar Libraries

Ferla, B. L., Cipolla, L., & Nicotra, F. (2007) · doi:10.1002/9780470517437.ch3 · Cited by 11

Mice primed with swainsonine are protected against doxorubicin-induced lethality.

Oredipe, O. A., Furbert-Harris, P. M., Laniyan, I., Wr, G., Griffin, W. M., & Sridhar, R. (2003) · PubMed · Cited by 11

CB-12181, a New Azasugar-Based Matrix Metalloproteinase/Tumor Necrosis Factor-α Converting Enzyme Inhibitor, Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis in Vitro and Retinal Neovascularization in Vivo

Chikaraishi, Y., Shimazawa, M., Yokota, K., Yoshino, K., & Hara, H. (2009) · Current Neurovascular Research · doi:10.2174/156720209788970072 · Cited by 10

Isofagomine tartrate

Dulsat, C., & Mealy, N. (2009) · Drugs of the Future · doi:10.1358/dof.2009.034.01.1323946 · Cited by 10

Gaucher´s Disease

Dulsat, C. (2009) · Drugs of the Future · doi:10.1358/dof.2009.034.02.1336030 · Cited by 8

INK4 genes in pancreatic carcinoma

Rozenblum, E., Schute, M., & Kern, S. E. (1996) · Oncology Reports · doi:10.3892/or.3.4.743 · Cited by 8

The O-GlcNAc modification: three-dimensional structure, enzymology and the development of selective inhibitors to probe disease

Davies, G. J., & Martinez-Fleites, C. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381179 · Cited by 8

Iminosugars as Antiviral Agents

Norton, P. A., Gu, B., & Block, T. M. (2007) · doi:10.1002/9780470517437.ch9 · Cited by 6

Introduction to Carbohydrate Structure and Diversity

Herget, S., Ranzinger, R., Thomson, R. J., Frank, M., & von der Lieth, C. (2009) · doi:10.1002/9780470029619.ch2 · Cited by 4

Dynamic Crosstalk between GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription and Human Disease (Supplementary Material)

Shimoji, S., Park, K., & Hart, G. W. (2010) · Current Signal Transduction Therapy · doi:10.2174/157436210790226528 · Cited by 4

Iminosugars as Therapeutic Agents: Recent Advances and Promising Trends

Nash, R. J., Kato, A., Yu, C.-Y., & Fleet, G. W. J. (2011) · Future Medicinal Chemistry · doi:10.4155/fmc.11.117 · Cited by 302

Carbohydrate based Potential Chemotherapeutic Agents: Recent Developments and their Scope in Future Drug Discovery

Tiwari, V. K., Mishra, R. C., Sharma, A., & Tripathi, R. P. (2012) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712803832654 · Cited by 97

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin‐Based Iminosugar Click Clusters

Decroocq, C., Joosten, A. Y. P., Sergent, R., Barragán, T. M., Mellet, C. O., & Compain, P. (2013) · ChemBioChem · doi:10.1002/cbic.201300283 · Cited by 61

Looking-Glass Synergistic Pharmacological Chaperones: DGJ and L-DGJ from the Enantiomers of Tagatose

Jenkinson, S. F., Fleet, G. W. J., Nash, R. J., Koike, Y., Adachi, I., Yoshihara, A., Morimoto, K., Izumori, K., & Kato, A. (2011) · Organic Letters · doi:10.1021/ol201552q · Cited by 56

Access to l - and d -Iminosugar C-Glycosides from a d -gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy

Mondon, M., Fontelle, N., Désiré, J., Lecornué, F., Guillard, J., Marrot, J., & Blériot, Y. (2012) · Organic Letters · doi:10.1021/ol203385w · Cited by 47

Iminosugars: Therapeutic Applications and Synthetic Considerations

Horne, G. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_50 · Cited by 20

Iminosugars

Ramesh, N. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816675-8.00008-7 · Cited by 11

Recent synthetic strategies to access diverse iminosugars

Matassini, C., & Cardona, F. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91729-2.00003-3 · Cited by 2

The synthesis and biology of iminosugars and their precursors

Ayers, B. J., & Ayers, B. (2014) · Oxford University Research Archive (ORA) (University of Oxford) · doi:10.5287/ora-eqedyk11r

Iminosugars past, present and future: Medicines for tomorrow

Horne, G., Wilson, F. X., Tinsley, J., Williams, D. H., & Storer, R. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2010.08.017 · Cited by 320