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Cited by 118Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyAmino Acid Enzymes and Metabolism

The NMDA Receptor Channel: Molecular Design of a Coincidence Detector

SEEBURG, PETER H., BURNASHEV, NAIL, KÖHR, GEORG, KUNER, THOMAS, SPRENGEL, ROLF, MONYER, HANNAH·1995·Proceedings of the 1993 Laurentian Hormone Conference
DOI 10.1016/b978-0-12-571150-0.50006-8
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Crossref · 10.1016/b978-0-12-571150-0.50006-8

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  • NMDARs act as coincidence detectors: depolarization plus glutamate and glycine co-agonism are needed to remove the magnesium block and open the channel.

    “NMDARs play a unique role in excitatory transmission, functioning as “coincidence detectors”, whereby cellular depolarization and co-agonism by glutamate and glycine are necessary for the magnesium block to be removed and the channel to open [24].”

    From Ketamine in neuropsychiatric disorders: an update (2024) · cites this paper as [24]

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Authors
SEEBURG, P. H., BURNASHEV, N., KÖHR, G., KUNER, T., SPRENGEL, R., & MONYER, H.
Affiliations
  • Heidelberg University (DE)
  • Max Planck Institute for Medical Research (DE)
ORCID
Venue
Proceedings of the 1993 Laurentian Hormone Conference
Publisher
Elsevier
Published
1995
Volume
50
Pages
19-34
DOI
10.1016/b978-0-12-571150-0.50006-8
OpenAlex
W61569094
Cited by
118
References
1
Citations by year
2026: 2 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 9 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 4
FWCI
62.40
Type
conference paper
Language
en
Open access
closed
Locations
  • Elsevier eBooks (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
NMDA receptor, coincidence detection, glutamate receptor channels, NR2 subunits, synaptic plasticity, visual cortex development, dark rearing, NR2C, NR2D, postsynaptic currents, excitatory synaptic transmission
MeSH terms
Amino Acid Sequence, Animals, Central Nervous System, Molecular Biology, Molecular Sequence Data, Synaptic Transmission, Receptors, N-Methyl-D-Aspartate

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