An Environmental Antiandrogen
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Vz is biotransformed into at least two active metabolites that bind competitively to the human, monkey, and rat androgen receptor.
“Vz is biotransformed into at least two active metabolites that bind competitively to the human, monkey, and rat androgen receptor (Kelce and Monosson 1995; Kelce et al. 1994).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Kelce and Monosson 1995
Cites
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Self-citationMethyltrienolone, a specific ligand for cellular androgen receptors
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In utero exposure to organochlorines and age at menarche
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Anatomy and Physiology of the Male Reproductive System and Potential Targets of Toxicants
Ing, N. H., Curley, K. O., Welsh, T. H., Johnson, L. W., Luense, L. J., Clement, T. M., & Staub, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00208-4
- Authors
- KELCE, W. R., MONOSSON, E., & GRAY, L. E.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Environmental Protection Agency (US)
- Venue
- Proceedings of the 1993 Laurentian Hormone Conference
- Publisher
- Elsevier
- Published
- 1995
- Volume
- 50
- Pages
- 449-453
- OpenAlex
- W10692727
- Cited by
- 28
- References
- 9
- Citations by year
- 2024: 1 · 2021: 1 · 2019: 1 · 2016: 4 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.44
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Elsevier eBooks (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- vinclozolin, antiandrogenic effects, endocrine disruptors, pesticide metabolites, androgen receptor antagonism, 5α-reductase inhibition, dihydrotestosterone, 5α-androstane-3α,17β-diol, competitive antagonism, plant uptake of pesticides
- MeSH terms
- Abnormalities, Multiple, Androgen Antagonists, Animals, Binding, Competitive, Biodegradation, Environmental, Female, Fungicides, Industrial, Male, Oxazoles, Oxidoreductases, Pregnancy, Soil Pollutants, Cholestenone 5 alpha-Reductase, Rats, Androgen Receptor Antagonists
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