Cited by 204Proteoglycans and glycosaminoglycans researchHydrogels: synthesis, properties, applicationsProtease and Inhibitor Mechanisms

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Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy

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Caitlin O. McAtee, Joseph J. Barycki, Melanie A. Simpson·2014·Advances in Cancer Research

DOI 10.1016/b978-0-12-800092-2.00001-0PMC PMC4445717

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Abstract

Hyaluronidases are a family of five human enzymes that have been differentially implicated in the progression of many solid tumor types, both clinically and in functional studies. Advances in the past 5 years have clarified many apparent contradictions: (1) by demonstrating that specific hyaluronidases have alternative substrates to hyaluronan (HA) or do not exhibit any enzymatic activity, (2) that high-molecular weight HA polymers elicit signaling effects that are opposite those of the hyaluronidase-digested HA oligomers, and (3) that it is actually the combined overexpression of HA synthesizing enzymes with hyaluronidases that confers tumorigenic potential. This review examines the literature supporting these conclusions and discusses novel mechanisms by which hyaluronidases impact invasive tumor cell processes. In addition, a detailed structural and functional comparison of the hyaluronidases is presented with insights into substrate selectivity and potential for therapeutic targeting. Finally, technological advances in targeting hyaluronidase for tumor imaging and cancer therapy are summarized.

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Authors: McAtee, C. O., Barycki, J. J., & Simpson, M. A.
Affiliations: University of Nebraska–Lincoln (US)
Corresponding author: Melanie A. Simpson
ORCID: Joseph J. Barycki
Melanie A. Simpson
Venue: Advances in Cancer Research
Publisher: Elsevier
Published: 2014
Volume: 123
Pages: 1-34
ISSN: 0065-230X (ISSN-L)
DOI: 10.1016/b978-0-12-800092-2.00001-0
PMC: PMC4445717
OpenAlex: W2394990651
Cited by: 204
References: 127
Citations by year: 2026: 3 · 2025: 17 · 2024: 14 · 2023: 24 · 2022: 19 · 2021: 20 · 2020: 25 · 2019: 28 · 2018: 14 · 2017: 15 · 2016: 12 · 2015: 12 · 2014: 1
FWCI: 18.61
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Advances in cancer research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Lincoln (University of Nebraska) (submittedVersion)
Funders: National Institutes of Health (8p20gm103489-10)
National Cancer Institute (R01CA165574)
National Institute of General Medical Sciences (P20-GM103489)
National Center for Research Resources (P20RR018759)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: hyaluronidase, hyaluronic acid, metastasis, tumor invasion, hyaluronan oligosaccharides, hyaluronan synthase, substrate specificity, enzyme structure, hyaluronidase inhibitors, tumor imaging, cancer therapy
MeSH terms: Animals, Cell Movement, Fibroblasts, Humans, Hyaluronic Acid, Hyaluronoglucosaminidase, Molecular Conformation, Molecular Weight, Neoplasm Metastasis, Neoplasms, Polymers, Prognosis, Alternative Splicing, Disease Progression, Mole Rats, Rats

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