The DOI matches its Crossref record; 338 of the 338 references it cites were found in a registry or an index.
Methods for Gene Transfer to the Central Nervous System
Open accessAbstract
Gene transfer is an increasingly utilized approach for research and clinical applications involving the central nervous system (CNS). Vectors for gene transfer can be as simple as an unmodified plasmid, but more commonly involve complex modifications to viruses to make them suitable gene delivery vehicles. This chapter will explain how tools for CNS gene transfer have been derived from naturally occurring viruses. The current capabilities of plasmid, retroviral, adeno-associated virus, adenovirus, and herpes simplex virus vectors for CNS gene delivery will be described. These include both focal and global CNS gene transfer strategies, with short- or long-term gene expression. As is described in this chapter, an important aspect of any vector is the cis-acting regulatory elements incorporated into the vector genome that control when, where, and how the transgene is expressed.
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“AAV vectors support long-term, non-toxic gene expression for up to 8 years in non-human primates.1–3”
From Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism (2016) · cites this paper as [3]
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1 retracted
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RetractedIn Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
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Cited by
Sorted by citations
Strategies for delivering therapeutics across the blood–brain barrier
Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138
Ortinski, P. I., O’Donovan, B., Dong, X., & Kantor, B. (2017) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2017.04.002 · Cited by 146
Self-citationCharacterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism
Powell, S. K., Khan, N., Parker, C. L., Samulski, R. J., Matsushima, G., Gray, S. J., & McCown, T. J. (2016) · Gene Therapy · doi:10.1038/gt.2016.62 · Cited by 92
Self-citationVijayraghavan, S., & Kantor, B. (2017) · Journal of Visualized Experiments · doi:10.3791/56915 · Cited by 20
Self-citationStolte, B., Schreiber-Katz, O., Günther, R., Wurster, C. D., Petri, S., Osmanovic, A., Freigang, M., Uzelac, Z., Leo, M., von Velsen, O., et al. (2022) · Human Gene Therapy · doi:10.1089/hum.2022.054 · Cited by 15
Metadata
- Authors
- Kantor, B., Bailey, R. M., Wimberly, K., Kalburgi, S. N., & Gray, S. J.
- Affiliations
- University of South Carolina (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Gray, Steven J.
- Venue
- Advances in Genetics
- Publisher
- Elsevier
- Published
- 2014
- Volume
- 87
- Pages
- 125-197
- ISSN
- 0065-2660 (ISSN-L)
- PMC
- PMC4519829
- OpenAlex
- W2414165069
- Cited by
- 109
- References
- 338
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 17 · 2020: 9 · 2019: 6 · 2018: 11 · 2017: 9 · 2016: 14 · 2015: 1
- FWCI
- 20.49
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (P30NS045892, R01NS087175)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- gene delivery vectors, plasmid vectors, retroviral vectors, adeno-associated virus vectors, adenoviral vector, herpes simplex virus vectors, cis-regulatory elements, transgene expression
- MeSH terms
- Adenoviridae, Central Nervous System, Genetic Vectors, Humans, Genetic Therapy, Gene Expression, Lentivirus, Gene Transfer Techniques, Simplexvirus
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