The DOI matches its Crossref record; 233 of the 237 references it cites were found in a registry or an index.
CSF in acute and chronic infectious diseases
Open accessAbstract
Infections of the nervous system are an important and challenging aspect of clinical neurology. Immediate correct diagnosis enables to introduce effective therapy, in conditions that without diagnosis may leave the patient with severe neurological incapacitation and sometimes even death. The cerebrospinal fluid (CSF) is a mirror that reflects nervous system pathology and can promote early diagnosis and therapy. The present chapter focuses on the CSF findings in neuro-infections, mainly viral and bacterial. Opening pressure, protein and glucose levels, presence of cells and type of the cellular reaction should be monitored. Other tests can also shed light on the causative agent: serology, culture, staining, molecular techniques such as polymerase chain reaction. Specific examination such as panbacterial and panfungal examinations should be examined when relevant. Our chapter is a guide-text that combines clinical presentation and course with CSF findings as a usuaful tool in diagnosis of neuroinfections.
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“These results are consistent with the assumption, that viral infections can lead to a modest change in cerebrospinal fluid parameters (18, 27)”
From Utilization of a Meningitis/Encephalitis PCR panel at the University Hospital Basel – a retrospective study to develop a diagnostic decision rule (2024) · cites this paper as [27]
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Cites
Items 201–233 of 233
Jellinger, K. A. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02495.x · Cited by 17
Granulome cérébral à Candida albicans chez un patient immunocompétent. Cas clinique
Borha, A., Parienti, J., Emery, É., Coskun, O., Khouri, S., & Derlon, J.-M. (2008) · Neurochirurgie · doi:10.1016/j.neuchi.2008.06.001 · Cited by 16
Intracranial Aspergillus Granuloma
Sundaram, C., & Murthy, J. M. K. (2011) · Pathology Research International · doi:10.4061/2011/157320 · Cited by 16
Opota, O., Desgraz, B., Kenfak-Foguena, A., Jaton, K., Cavassini, M. L., Greub, G., Prod’hom, G., & Giulieri, S. G. (2014) · New Microbes and New Infections · doi:10.1016/j.nmni.2014.12.003 · Cited by 14
Hypoglycorrhachia in Herpes Simplex Encephalitis
Davis, R., Jeffery, K. J., & Atkins, B. L. (2004) · Clinical Infectious Diseases · doi:10.1086/383579 · Cited by 12
Haynes, B. F. (1976) · JAMA · doi:10.1001/jama.1976.03270180043019 · Cited by 12
Mutational and functional analysis of Glucose transporter I deficiency syndrome
Nakamura, S., Osaka, H., Muramatsu, S., Aoki, S., Jimbo, E. F., & Yamagata, T. (2015) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2015.08.006 · Cited by 11
Sharief, M. K., & Thompson, E. J. (1990) · Journal of Immunological Methods · doi:10.1016/0022-1759(90)90294-6 · Cited by 11
PCR Detection of Host and HIV-1 Sequences from Archival Brain Tissue
Smith, K. M., Crandall, K. A., Kneissl, M., & NAVIA, B. A. (2000) · Journal of NeuroVirology · doi:10.3109/13550280009013160 · Cited by 11
Nested PCR Assay for Eight Pathogens: A Rapid Tool for Diagnosis of Bacterial Meningitis
Bhagchandani, S. P., Kubade, S., Nikhare, P. P., Manke, S., Chandak, N. H., Kabra, D. P., Baheti, N., Agrawal, V. S., Sarda, P., Mahajan, P., et al. (2015) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-015-0174-z · Cited by 11
Viral meningitis: epidemiology and diagnosis
Harvala, H., & Peter Simmonds, K. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30221-3 · Cited by 11
Molecular Approaches to the Diagnosis of Meningitis and Encephalitis
Bloch, K., & Tang, Y.-W. (2016) · Molecular Microbiology · doi:10.1128/9781555819071.ch24 · Cited by 10
BACTERIOLYTIC ACTIVITY OF NORMAL AND PATHOLOGICAL CEREBROSPINAL FLUID
Bratlid, D., & Bøvre, K. (1977) · Acta Pathologica Microbiologica Scandinavica Section C Immunology · doi:10.1111/j.1699-0463.1977.tb03606.x · Cited by 9
A study on viral CNS inflammation beyond herpes encephalitis
Jordan, B., Kösling, S., Emmer, A., Koch, A., Müller, T., & Kornhuber, M. E. (2016) · Journal of NeuroVirology · doi:10.1007/s13365-016-0452-5 · Cited by 9
Síndrome MELAS que asemeja una encefalitis por virus herpes: diagnóstico genético
Heras, M. D. T., Guzmán, J. D., Martínez, D. A. P., Díaz, R. A. S., Vallejo, A. R., & González, Y. C. (2001) · Revista de Neurología · doi:10.33588/rn.3302.2001016 · Cited by 9
Looking for fungi in all the right places
Greene, G., Sriruttan, C., Le, T. P., Chiller, T. M., & Govender, N. P. (2017) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000347 · Cited by 9
Bicanic, T. A., Ogden, D., Whitney, L., Loyse, A., & Jarvis, J. N. (2012) · HIV Medicine · doi:10.1111/j.1468-1293.2012.01022.x · Cited by 8
Cerebrospinal fluid lactate: measurement of an adult reference interval
Slack, S. D., Turley, P., Allgar, V. L., & Holbrook, I. (2015) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563215591633 · Cited by 8
Infectious Diseases of the Central Nervous System
Thompson, R. A., & Green, J. R. (1984) · Springer eBooks · doi:10.1007/978-94-011-6332-3 · Cited by 7
Periodic lateralized epileptiform discharges (PLEDs) in herpetic encephalitis
Martins, W. A., & Palmini, A. (2015) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20150149 · Cited by 6
Aspergillus arteritis of the right internal carotid artery resulting in massive stroke
Radotra, B., Chatterjee, D., & Mukherjee, K. K. (2016) · Neurology India · doi:10.4103/0028-3886.190233 · Cited by 6
Cerebrospinal fluid and plasma HIV-1 RNA stability at 4°C
Ahmad, M., Tashima, K. T., Caliendo, A. M., & Flanigan, T. (1999) · AIDS · doi:10.1097/00002030-199907090-00023 · Cited by 5
Steroid‐responsive, progressive, focal measles virus brain infection
Steiner, I., Livneh, V., Hoffmann, C., Nass, D., Mor, O., & Chapman, J. (2014) · Annals of Neurology · doi:10.1002/ana.24183 · Cited by 5
Electroencephalographic Evaluation for Early Diagnosis of Limbic Encephalitis
Pessa, M. E., Janes, F., & Gigli, G. L. (2014) · Clinical EEG and Neuroscience · doi:10.1177/1550059414547758 · Cited by 5
The toll (like receptor 3) to the pathogenesis of herpes simplex encephalitis
Steiner, I., & Tyler, K. L. (2014) · Neurology · doi:10.1212/wnl.0000000000001011 · Cited by 4
Infectious Diseases of the Central Nervous System
Dousset, V., & Bonafé, A. (2012) · Springer eBooks · doi:10.1007/978-88-470-2628-5_15 · Cited by 3
West Nile Virus Infection Causing Hypoglycorrhachia in an HIV-infected Man
Unzek, S., Salata, R. A., & Armitage, K. B. (2006) · Infectious Diseases in Clinical Practice · doi:10.1097/01.idc.0000214369.54423.f9 · Cited by 3
Improvement of SSPE by intrathecal infusion of α-IFN
Wirguin, I., Vander, T., Brenner, T., Abramsky, O., & Steiner, I. (2005) · Neurology · doi:10.1212/wnl.64.2.402 · Cited by 3
Herpes Simplex Virus Meningoencephalitis
Steiner, I. (2012) · Springer eBooks · doi:10.1007/978-3-0348-0425-7_3 · Cited by 2
Bianchi, L., Napoli, Z., Donati, S., Lencioni, P., Santoni, F., & Lari, R. (2015) · Microbiologia medica · doi:10.4081/mm.2015.5084 · Cited by 2
The Role of Toll-Like Receptor 3 in Epileptogenesis (I1-2.001)
Benninger, F., Gross, A., Steiner, I., Offen, D., & Okun, E. (2014) · Neurology · doi:10.1212/wnl.82.10_supplement.i1-2.001 · Cited by 1
Acute confusion and seizures in a 63-year-old woman
Benninger, F., Shemesh, T., & Steiner, I. (2012) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2012.02.018 · Cited by 1
[Hypoglycorrhachia as an early sign of central nervous system infection caused by HIV].
Farinelli, M., Camera, M., Bono, V. D., Fiorelli, M., Panavese, C., & Valguarnera, F. (1989) · PubMed · Cited by 1
Research works printed but not linked: 2
- de Toledo, 2001, MELAS syndrome masquerading as herpes encephalitis: genetic diagnosis, Rev Neurol, 33, 148
- Viallon, 2000, Rapid differential diagnosis between bacterial and viral meningitis with serum procalcitonin assay in adults, Presse Med, 29, 584
Cited by
Sorted by citations
Cell-free DNA-based liquid biopsies in neurology
Gaitsch, H., Franklin, R. J. M., & Reich, D. S. (2022) · Brain · doi:10.1093/brain/awac438 · Cited by 84
Macrophage compartmentalization in the brain and cerebrospinal fluid system
Munro, D. A. D., Movahedi, K., & Priller, J. (2022) · Science Immunology · doi:10.1126/sciimmunol.abk0391 · Cited by 59
Self-Assembled Au Nanoparticle Arrays for Precise Metabolic Assay of Cerebrospinal Fluid
Wang, Y., Zhang, K., Tian, T., Shan, W., Qiao, L., & Liu, B. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c20944 · Cited by 54
Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus
Bramall, A. N., Anton, E. S., Kahle, K. T., & Fecci, P. E. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103931 · Cited by 38
Fluid Biomarkers in Dementia Diagnosis
Schindler, S. E. (2022) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001083 · Cited by 31
Metadata
- Authors
- Benninger, F., & Steiner, I.
- Affiliations
- Rabin Medical Center (IL)
- Corresponding author
- Felix Benninger
- ORCID
- Felix Benninger
- Venue
- Handbook of clinical neurology
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 146
- Pages
- 187-206
- ISSN
- 0072-9752 (ISSN-L)
- PMC
- PMC7150022
- OpenAlex
- W2767051226
- Cited by
- 42
- References
- 237
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 4 · 2022: 12 · 2021: 4 · 2020: 1 · 2019: 1
- FWCI
- 1.74
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Handbook of clinical neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- cerebrospinal fluid analysis, central nervous system infection, viral meningitis, bacterial meningitis, CSF opening pressure, cerebrospinal fluid protein, CSF glucose, CSF cell count, cerebrospinal fluid culture, serology, PCR, early diagnosis
- MeSH terms
- Acute Disease, Animals, Cerebrospinal Fluid, Chronic Disease, Communicable Diseases, Electroencephalography, Humans, Polymerase Chain Reaction
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