History, introduction, and properties of PLGA as a drug delivery carrier
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A 50:50 LA:GA ratio results in a faster-degrading, more amorphous structure suitable for short-term barrier applications, while a higher lactic acid content (e.g., 85:15 LA:GA) increases crystallinity and hydrophobicity, leading to slower degradation and prolonged tissue separation.
“A 50:50 ratio results in a faster-degrading, more amorphous structure, suitable for short-term barrier applications, while a higher lactic acid content (e.g., 85:15 LA:GA) increases crystallinity and hydrophobicity, leading to slower degradation and prolonged tissue separation [226,227,228].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [228]
Cites
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
Makadia, H. K., & Siegel, S. J. (2011) · Polymers · doi:10.3390/polym3031377 · Cited by 4,816 · see citing works
An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering
Gentile, P., Chiono, V., Carmagnola, I., & Hatton, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033640 · Cited by 1,593 · see citing works
Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery
Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., & Farokhzad, O. C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.047 · Cited by 1,273 · see citing works
Effect of acidic pH on PLGA microsphere degradation and release
Zolnik, B. S., & Burgess, D. J. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.034 · Cited by 560 · see citing works
Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
Tobío, M., Gref, R., Sánchez, A., Langer, R., & Alonso, M. J. (1998) · Pharmaceutical Research · doi:10.1023/a:1011922819926 · Cited by 402 · see citing works
PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination
Garinot, M., Fiévez, V., Pourcelle, V., Stoffelbach, F., des Rieux, A., Plapied, L., Theate, I., Freichels, H., Jérôme, C., Marchand-Brynaert, J., et al. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.04.021 · Cited by 331 · see citing works
Effect of drug type on the degradation rate of PLGA matrices
SIEGEL, S., KAHN, J., METZGER, K., WINEY, K., WERNER, K., & DAN, N. (2006) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.06.009 · Cited by 208 · see citing works
Bazile, D. V., Ropert, C., Huve, P., Verrecchia, T., Mariard, M., Frydman, A., Veillard, M., & Spenlehauer, G. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90142-b · Cited by 200 · see citing works
Targeted delivery of paclitaxel using folate-decorated poly(lactide)-vitamin E TPGS nanoparticles
Pan, J., & Feng, S.-S. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.02.020 · Cited by 187 · see citing works
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Yurtdaş Kırımlıoğlu, G.
- Venue
- Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery
- Publisher
- Elsevier
- Published
- 2023
- Pages
- 3-25
- OpenAlex
- W4327779836
- Cited by
- 9
- References
- 9
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 1
- FWCI
- 4.94
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Elsevier eBooks (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- PLGA, poly(lactic-co-glycolic acid), drug carriers, biodegradable polymers, polymeric micelles, polymer properties
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