PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination
Abstract
To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles displaying RGD molecules at their surface were designed to target human M cells. RGD grafting was performed by an original method called "photografting" which covalently linked RGD peptides mainly on the PEG moiety of the PCL-PEG, included in the formulation. First, three non-targeted formulations with size and zeta potential adapted to M cell uptake and stable in gastro-intestinal fluids, were developed. Their transport by an in vitro model of the human Follicle associated epithelium (co-cultures) was largely increased as compared to mono-cultures (Caco-2 cells). RGD-labelling of nanoparticles significantly increased their transport by co-cultures, due to interactions between the RGD ligand and the beta(1) intregrins detected at the apical surface of co-cultures. In vivo studies demonstrated that RGD-labelled nanoparticles particularly concentrated in M cells. Finally, ovalbumin-loaded nanoparticles were orally administrated to mice and induced an IgG response, attesting antigen ability to elicit an immune response after oral delivery.
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Very low IL-4 and significantly higher IFN-γ production by spleen cells was observed in animals immunized with particles compared with mice fed unprotected OVA, and this was more pronounced when β1 integrin on M cells was targeted by an RGD-containing peptide.
“Moreover, very low IL-4 and significantly higher IFN-γ production of spleen cells was observed in animals immunized with particles compared with mice being fed unprotected OVA, which was even more pronounced when the β1 integrin on M cells was specifically targeted by an RGD-containing peptide [76].”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [76]
Encapsulation of antigens into PLGA particles both protects from GI digestion and initiates specific immune responses through IgG and IFN-γ production at very low antigen amounts.
“Recently, it was observed that the encapsulation of antigens into PLGA particles did not only protect from GI digestion, but also initiated specific immune responses by the means of IgG and IFN-γ production at very low antigen amounts [76].”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [76]
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- Authors
- Garinot, M., Fiévez, V., Pourcelle, V., Stoffelbach, F., des Rieux, A., Plapied, L., Theate, I., Freichels, H., Jérôme, C., Marchand-Brynaert, J., Schneider, Y.-J., & Préat, V.
- Affiliations
- UCLouvain (BE)
- University of Liège (BE)
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 120
- Issue
- 3
- Pages
- 195-204
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W1982938211
- Cited by
- 331
- References
- 37
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 12 · 2022: 17 · 2021: 15 · 2020: 23 · 2019: 19 · 2018: 26 · 2017: 20 · 2016: 24 · 2015: 22 · 2014: 21 · 2013: 21 · 2012: 23
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- oral immunization, M cells, RGD peptide, photografting, follicle-associated epithelium, nanoparticle uptake, ovalbumin, IgG antibody response, oral vaccine delivery
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Administration, Oral, Animals, Epithelial Cells, Female, Ovarian Follicle, Humans, Immunization, Secondary, Injections, Intramuscular, Intestinal Mucosa, Mice, Inbred Strains, Oligopeptides, Ovalbumin, Peyer's Patches, Polyethylene Glycols, Polyglycolic Acid, Polymers, Vaccination, Fluorescein-5-isothiocyanate, Coculture Techniques, Caco-2 Cells, Integrin beta1, Lactic Acid, Integrin alpha5beta1, Cell Line, Tumor, Mice, Nanoparticles
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