Cognition and daytime functioning in sleep-related breathing disorders
Abstract
Sleep-related breathing disorders encompass a range of disorders in which abnormal ventilation occurs during sleep as a result of partial or complete obstruction of the upper airway, altered respiratory drive, abnormal chest wall movement, or respiratory muscle function. The most common of these is obstructive sleep apnea (OSA), occurring in both adults and children, and causing significant cognitive and daytime dysfunction and reduced quality of life. OSA patients experience repetitive brief cessation of breathing throughout the night, which causes intermittent hypoxemia (reductions in hemoglobin oxygen levels) and fragmented sleep patterns. These nocturnal events result in excessive daytime sleepiness, and changes in mood and cognition. Chronic excessive sleepiness during the day is a common symptom of sleep-related breathing disorders, which is assessed in sleep clinics both subjectively (questionnaire) and objectively (sleep latency tests). Mood changes are often reported by patients, including irritability, fatigue, depression, and anxiety. A wide range of cognitive deficits have been identified in untreated OSA patients, from attentional and vigilance, to memory and executive functions, and more complex tasks such as simulated driving. These changes are reflected in patient reports of difficulty in concentrating, increased forgetfulness, an inability to make decisions, and falling asleep at the wheel of a motor vehicle. These cognitive changes can also have significant…
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Declines in daytime function in individuals with OSA can translate into higher rates of job-related and motor vehicle accidents.
“These declines in daytime function can translate into higher rates of job-related and motor vehicle accidents.15”
From Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline (2017) · cites this paper as [15]
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- Authors
- Jackson, M. L., Howard, M. E., & Barnes, M.
- Affiliations
- Washington State University Spokane (US)
- Austin Hospital (AU)
- Corresponding author
- Jackson, Melinda L.
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2011
- Volume
- 190
- Pages
- 53-68
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1668612790
- Cited by
- 202
- References
- 5
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 15 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 18 · 2019: 13 · 2018: 18 · 2017: 9 · 2016: 15 · 2015: 16 · 2014: 16 · 2013: 14 · 2012: 14
- FWCI
- 66.09
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- obstructive sleep apnea, sleep-disordered breathing, cognitive impairment, daytime functioning, excessive daytime sleepiness, mood disorders, attention and vigilance, memory, executive function, intermittent hypoxemia, sleep fragmentation, motor vehicle accidents, comorbidities, neuroimaging, quality of life
- MeSH terms
- Affect, Automobile Driving, Cognition, Cognition Disorders, Humans, Disorders of Excessive Somnolence, Neuropsychological Tests, Psychomotor Performance, Sleep Apnea Syndromes, Executive Function
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