Lipid profile after long-term APAP in OSA patients
Open accessAbstract
Purpose This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure (APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. Besides contributing to the comprehension of the complex relationship between dyslipidemia and OSA, it provided new data regarding the effectiveness of a long term APAP treatment.Methods Thirty-nine male patients with moderate to severe OSA were included in the study. APAP was prescribed to all patients. Fifteen patients were under lipid-lowering medication throughout the study, and another 15 patients never used lipid-lowering medication at any time during the study. Fasting morning venous blood samples were collected at three time points (baseline 6 months and 8 years) and lipids were estimated. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) 21.0 software.Results After 8 years of APAP treatment, patients presented a similar body mass index but a significantly less severe daytime sleepiness. Patients on lipid-lowering medication exhibited a higher reduction in total cholesterol than those naïf from that medication, but the reduction was not statistically significant after adjusting for medication and APAP adherence.Conclusions Long-term APAP treatment improves OSA but does not seem to contribute to changes in fasting lipids.
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2 retracted
RETRACTED: CPAP for the Metabolic Syndrome in Patients with Obstructive Sleep Apnea
Sharma, S. K., Agrawal, S., Damodaran, D., Sreenivas, V., Kadhiravan, T., Ramakrishnan, L., Jagia, P., & Kumar, A. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103944 · Cited by 367 · see citing works
RetractedSharma, S. K., Agrawal, S., Damodaran, D., Sreenivas, V., Kadhiravan, T., Ramakrishnan, L., Jagia, P., & Kumar, A. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1313105 · Cited by 21 · see citing works
RetractedDetection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198 · see citing works
The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S., & Badr, S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304293281704 · Cited by 10,183 · cited 1× · see citing works
“Besides OSA is a common disorder, it is a major cause of morbidity and significant cause of mortality [6–10] and the most common cause of daytime sleepiness [11, 12].”
BackgroundMarin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71141-7 · Cited by 4,678 · see citing works
Increased Prevalence of Sleep-Disordered Breathing in Adults
Peppard, P. E., Young, T., Barnet, J. H., Palta, M., Hagen, E. W., & Hla, K. M. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws342 · Cited by 4,618 · see citing works
The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
Aziz, F., & Chaudhary, K. R. (2016) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,285 · see citing works
The epidemiology of adult obstructive sleep apnea
Punjabi, N. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200709-155mg · Cited by 2,361 · see citing works
Adherence to Continuous Positive Airway Pressure Therapy: The Challenge to Effective Treatment
Weaver, T. E., & Grunstein, R. R. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-119mg · Cited by 1,680 · see citing works
Obstructive Sleep Apnea–Hypopnea and Incident Stroke: The Sleep Heart Health Study
Redline, S., Yenokyan, G., Gottlieb, D. J., Shahar, E., O'Connor, G. T., Resnick, H. E., Diener-West, M., Sanders, M. H., Wolf, P. A., Geraghty, E. M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200911-1746oc · Cited by 1,269 · see citing works
The Association between Sleep Apnea and the Risk of Traffic Accidents
Téran‐Santos, J., Jimenez-Gomez, A., & Cordero-Guevara, J. A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903183401104 · Cited by 1,252 · see citing works
McNicholas, W. T., Bonsignore, M. R., & the Management Committee of EU COST ACTION B26 (2007) · European Respiratory Journal · doi:10.1183/09031936.00027406 · Cited by 911 · see citing works
Drager, L. F., Togeiro, S. M., Polotsky, V. Y., & Lorenzi-Filho, G. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.045 · Cited by 886 · see citing works
Lenten, B. J. V., Hama, S. Y., de Beer, F. C., Stafforini, D. M., McIntyre, T. M., Prescott, S. M., Du, B. N. L., Fogelman, A. M., & Navab, M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118345 · Cited by 839 · see citing works
Long-term Use of CPAP Therapy for Sleep Apnea/Hypopnea Syndrome
McARDLE, N., DEVEREUX, G., HEIDARNEJAD, H., ENGLEMAN, H. M., MACKAY, T. W., & DOUGLAS, N. J. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.4.9807111 · Cited by 820 · see citing works
Clinical implications of dysregulated cytokine production
Slifka, M. K., & Whitton, J. L. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000086 · Cited by 677 · see citing works
Newman, A. B. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.1.50 · Cited by 603 · see citing works
Drager, L. F., Bortolotto, L. A., Figueiredo, A. C., Krieger, E. M., & Lorenzi‐Filho, G. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-500oc · Cited by 558 · see citing works
Barbé, F., Mayoralas, L. R., Duran, J., Masa, J. F., Maimó, A., Montserrat, J. M., Monasterio, C., Bosch, M., Ladaria, A., Rubio, M., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-11-200106050-00007 · Cited by 534 · see citing works
Obstructive Sleep Apnea and Metabolic Syndrome: Alterations in Glucose Metabolism and Inflammation
Tasali, E., & Ip, M. S. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-139mg · Cited by 365 · see citing works
Navab, M., Hama, S. Y., Hough, G. P., Subbanagounder, G., Reddy, S. T., & Fogelman, A. M. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31582-0 · Cited by 334 · see citing works
Early CPAP Use Identifies Subsequent Adherence to CPAP Therapy
(2007) · Sleep · doi:10.1093/sleep/30.3.320 · Cited by 329 · see citing works
Health-related quality of life in obstructive sleep apnoea
Lacasse, Y., Godbout, C., & Sériès, F. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00216902 · Cited by 320 · see citing works
Robinson, G. V. (2004) · Thorax · doi:10.1136/thx.2003.018739 · Cited by 318 · see citing works
Cardiovascular and metabolic effects of CPAP in obese males with OSA
Coughlin, S. R., Mawdsley, L., Mugarza, J. A., Wilding, J. P. H., & Calverley, P. M. (2007) · European Respiratory Journal · doi:10.1183/09031936.00043306 · Cited by 313 · see citing works
Jean‐Louis, G., Zizi, F., Clark, L. T., Brown, C. D., & McFarlane, S. I. (2008) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27191 · Cited by 303 · see citing works
Kohler, M., Stoewhas, A., Ayers, L., Senn, O., Bloch, K. E., Russi, E. W., & Stradling, J. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201106-0964oc · Cited by 288 · see citing works
Dorková, Z., Petrášová, D., Molčányiová, A., Popovnakova, M., & Tkáčová, R. (2008) · CHEST Journal · doi:10.1378/chest.08-0556 · Cited by 286 · see citing works
Drager, L. F., Lopes, H. F., Maki‐Nunes, C., Trombetta, I. C., Toschi‐Dias, E., Alves, M. J. N. N., Fraga, R. F., Jun, J. C., Negrão, C. E., Krieger, E. M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012065 · Cited by 284 · see citing works
Effect of high intensity intermittent training on heart rate variability in prepubescent children
Gamelin, F.-X., Baquet, G., Berthoin, S., Thévenet, D., Nourry, C., Nottin, S., & Bosquet, L. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0955-8 · Cited by 243 · see citing works
Obstructive Sleep Apnea and Cardiovascular Disease
Pack, A. I., & Gislason, T. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.01.002 · Cited by 228 · see citing works
Cognition and daytime functioning in sleep-related breathing disorders
Jackson, M. L., Howard, M. E., & Barnes, M. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53817-8.00003-7 · Cited by 202 · see citing works
HDL dysfunction in obstructive sleep apnea
Tan, K. C. B., Chow, W.-S., Lam, J., LAM, B. K., Wong, W.-K., Tam, S., & Ip, M. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.04.024 · Cited by 200 · see citing works
Gruber, A., Horwood, F., Sithole, J., Ali, N. D. A., & IDRIS, I. R. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-22 · Cited by 190 · see citing works
Obstructive sleep apnea and dyslipidemia: evidence and underlying mechanism
Adedayo, A. M., Olafiranye, O., Smith, D., Hill, A., Zizi, F., Brown, C., & Jean-Louis, G. (2014) · Sleep and Breathing · doi:10.1007/s11325-012-0760-9 · Cited by 182 · see citing works
Comparison between Automatic and Fixed Positive Airway Pressure Therapy in the Home
Massie, C. A., McArdle, N., Hart, R. W., Schmidt-Nowara, W. W., Lankford, A., Hudgel, D. W., Gordon, N., & Douglas, N. J. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200201-022oc · Cited by 177 · see citing works
Drager, L. F., Li, J. P., Shin, M., Reinke, C., Aggarwal, N. R., Jun, J. C., Bevans‐Fonti, S., Sztalryd, C., O’Byrne, S. M., Kroupa, O., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr097 · Cited by 168 · see citing works
Insulin resistance and daytime sleepiness in patients with sleep apnoea
Barceló, A., Barbé, F., de la Peña, M., Martinez, P., Soriano, J. B., Piérola, J., & Agustí, A. G. N. (2008) · Thorax · doi:10.1136/thx.2007.093740 · Cited by 167 · see citing works
HDL: The Metabolism, Function, and Therapeutic Importance
Wang, M., & Briggs, M. R. (2003) · Chemical Reviews · doi:10.1021/cr020466v · Cited by 157 · see citing works
Steiropoulos, P., Tsara, V., Nena, E., Fitili, C., Kataropoulou, M., Froudarakis, Μ. E., Christaki, P. I., & Bouros, D. E. (2007) · CHEST Journal · doi:10.1378/chest.07-0074 · Cited by 150 · see citing works
Phillips, C. L., Yee, B. J., Marshall, N. S., Liu, P. Y., Sullivan, D. R., & Grunstein, R. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201102-0316oc · Cited by 145 · see citing works
Serum Cardiovascular Risk Factors in Obstructive Sleep Apnea
Can, M., Açıkgöz, Ş., Mungan, G., Bayraktaroğlu, T., Koçak, E., Güven, B., & Demırtaş, S. (2006) · CHEST Journal · doi:10.1378/chest.129.2.233 · Cited by 136 · see citing works
Association of Incident Cardiovascular Disease With Progression of Sleep-Disordered Breathing
Chami, H. A., Resnick, H. E., Quan, S. F., & Gottlieb, D. J. (2011) · Circulation · doi:10.1161/circulationaha.110.974022 · Cited by 124 · see citing works
Comondore, V. R., Cheema, R., Fox, J. M., Butt, A., Mancini, G. B. J., Fleetham, J. A., Ryan, C. F., Chan, S., & Ayas, N. (2008) · Lung · doi:10.1007/s00408-008-9115-5 · Cited by 123 · see citing works
Quan, S. F., Budhiraja, R., Clarke, D. P., Goodwin, J. L., Gottlieb, D. J., Nichols, D. A., Simon, R., Smith, T. W., Walsh, J. K., & Kushida, C. A. (2013) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3064 · Cited by 114 · see citing works
Çuhadaroğlu, Ç., Utkusavaş, A., Öztürk, L., Salman, S., & Ece, T. (2009) · Lung · doi:10.1007/s00408-008-9131-5 · Cited by 114 · see citing works
CPAP effect on recurrent episodes in patients with sleep apnea and myocardial infarction
Rio, F. G., Alonso‐Fernández, A., Armada, E., Mediano, O., Lores, V., Rojo, B., Fernández-Lahera, J., Fernández-Navarro, I., Carpio, C., & Ramírez, T. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.12.015 · Cited by 109 · see citing works
Vatansever, E., Sürmen-Gür, E., Ursavaş, A., & Karadağ, M. (2010) · Sleep And Breathing · doi:10.1007/s11325-010-0378-8 · Cited by 90 · see citing works
Obstructive sleep apnoea/hypopnea influences high-density lipoprotein cholesterol in the elderly
Roche, F., Sforza, E. A., Pichot, V., Maudoux, D., Garcin, A., Celle, S., Picard-Kossovsky, M., Gaspoz, J., & Barthélemy, J. (2009) · Sleep Medicine · doi:10.1016/j.sleep.2008.07.017 · Cited by 84 · see citing works
Nguyen, P. K. P., Katikireddy, C. K., McConnell, M. V., Kushida, C. A., & Yang, P. C.-M. (2010) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-12-50 · Cited by 69 · see citing works
Nussbaumer, Y., Bloch, K. E., Genser, T., & Thurnheer, R. (2006) · Chest · doi:10.1378/chest.129.3.638 · Cited by 63 · see citing works
The art and science of continuous positive airway pressure therapy in obstructive sleep apnea
Malhotra, A., Ayas, N. T., & Epstein, L. J. (2000) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-200011000-00005 · Cited by 54 · see citing works
Obstructive sleep apnoea syndrome as a predictor of work disability
Sjösten, N., Mika Kivimaki, B., Oksanen, T., Salo, P., Saaresranta, T., Virtanen, M., Pentti, J., & Vahtera, J. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2009.01.014 · Cited by 53 · see citing works
Experimental Acute Renal Failure
Johnson, J. P., & Rokaw, M. D. (1995) · Update in intensive care and emergency medicine · doi:10.1007/978-3-642-79244-1_2 · Cited by 48 · see citing works
Optimal treatment of obstructive sleep apnea and excessive sleepiness
Rosenberg, R. P., & Doghramji, P. P. (2009) · Advances in Therapy · doi:10.1007/s12325-009-0016-7 · Cited by 45 · see citing works
Cardiovascular and metabolic comorbidities in patients with obstructive sleep apnoea syndrome.
Fusetti, M., Fioretti, A. B., Valenti, M., Masedu, F., Lauriello, M., & Pagliarella, M. (2012) · Europe PMC (PubMed Central) · Cited by 43 · see citing works
Obstructive Sleep Apnea Causes Systemic Inflammation and Metabolic Syndrome
Teramoto, S., Yamamoto, H., Yamaguchi, Y., Namba, R., & Ouchi, Y. (2005) · CHEST Journal · doi:10.1378/chest.127.3.1074 · Cited by 42 · see citing works
Obstructive sleep apnoea treatment and fasting lipids: a comparative effectiveness study
Keenan, B. T., Maislin, G., Sunwoo, B. Y., Arnardóttir, E. S., Jackson, N., Ólafsson, Í., Júlíusson, S., Schwab, R. J., Gíslason, Þ., Benediktsdóttir, B., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00043614 · Cited by 33 · see citing works
Resting Energy Expenditure in Adults With Sleep Disordered Breathing
Kezirian, E. J., Kirisoglu, C., Riley, R. W., Chang, E., Guilleminault, C., & Powell, N. B. (2008) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.134.12.1270 · Cited by 30 · see citing works
APAP impact on metabolic syndrome in obstructive sleep apnea patients
Mota, P. C., Drummond, M., Winck, J. C., Santos, A. C., Almeida, J., & Marques, J. A. (2010) · Sleep And Breathing · doi:10.1007/s11325-010-0417-5 · Cited by 26 · see citing works
Self-citationSize and Subclasses of Low-Density Lipoproteins in Patients With Obstructive Sleep Apnea
Sopkova, Z., Berneis, K. K., Rizzo, M., Spinas, G. A., Dorková, Z., Tisko, R., & Tkáčová, R. (2012) · Angiology · doi:10.1177/0003319711433811 · Cited by 21 · see citing works
Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea
Tisko, R., Sopkova, Z., Habalová, V., Dorková, Z., Slabá, E., Javorský, M., Tkáč, I., Riha, R. L., & Tkáčová, R. (2013) · European Respiratory Journal · doi:10.1183/09031936.00098513 · Cited by 15 · see citing works
Sleep-Disordered Breathing and Heart Disease
Man, S. F. P., & Sin, D. D. (2011) · Circulation · doi:10.1161/circulationaha.111.018945 · Cited by 3 · see citing works
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Sleep: important considerations for the prevention of cardiovascular disease
Grandner, M. A., Alfonso-Miller, P., Fernandez-Mendoza, J., Shetty, S., Shenoy, S., & Combs, D. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000324 · Cited by 166 · see citing works
Biological plausibility linking sleep apnoea and metabolic dysfunction
Gileles‐Hillel, A., Gozal, D., & Gozal, D. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.22 · Cited by 148 · see citing works
Obstructive sleep apnea and dyslipidemia: from animal models to clinical evidence
Barros, D., & Rio, F. G. (2018) · SLEEP · doi:10.1093/sleep/zsy236 · Cited by 136 · see citing works
Tan, H., Gozal, D., & Gozal, D. (2016) · Current Sleep Medicine Reports · doi:10.1007/s40675-016-0033-4 · Cited by 6 · see citing works
The effect of positive airway pressure therapy on lipid profile
Pazarlı, A. C., Köseoglu, H., Kanbay, A., & Abakay, M. A. (2018) · Eurasian Journal of Pulmonology · doi:10.4103/ejop.ejop_25_18 · Cited by 3 · see citing works
Study of dyslipidemia in patients with Obstructive Sleep Apnea Syndrome in primary health care
Ferraro, J., Rosendo, I., Santiago, L. M., & Simões, J. A. (2021) · Family Medicine & Primary Care Review · doi:10.5114/fmpcr.2021.103150 · Cited by 1 · see citing works
- Authors
- Rebelo, S., Drummond, M., & Marques, J. A.
- Affiliations
- Universidade do Porto (PT)
- Hospital de São João (PT)
- Corresponding author
- Rebelo, Sandra
- ORCID
- Drummond, Marta
- Venue
- Sleep And Breathing
- Published
- 2014-12-16
- Volume
- 19
- Issue
- 3
- Pages
- 931-937
- ISSN
- 1520-9512 (ISSN-L)
- 1522-1709
- OpenAlex
- W2001489112
- Cited by
- 6
- References
- 66
- Citations by year
- 2021: 1 · 2018: 2 · 2016: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc
- www.springer.com/tdm (tdm)
- Locations
- Sleep And Breathing (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc)
- Universidade do Porto
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- obstructive sleep apnea, CPAP therapy, dyslipidemia, total cholesterol, lipid-lowering drugs, body mass index, daytime sleepiness, CPAP adherence
- MeSH terms
- Adult, Aged, Hypolipidemic Agents, Combined Modality Therapy, Humans, Lipids, Male, Middle Aged, Prospective Studies, Multivariate Analysis, Polysomnography, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Dyslipidemias
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