Cited by 11Thermoregulation and physiological responsesThermal Regulation in MedicineNeuroscience of respiration and sleep

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Central thermoreceptors

Iustin V. Tabarean·2018·Handbook of Clinical Neurology

DOI 10.1016/b978-0-444-63912-7.00007-2

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Abstract

Homeotherms maintain their core body temperature within a narrow range by employing multiple redundant mechanisms to control heat production and dissipation. Preoptic area/anterior hypothalamic (PO/AH) neurons receive thermal signals from peripheral and deep-body thermoreceptors as well as hormonal and metabolic signals. A population of PO/AH neurons termed warm-sensitive increase their firing temperature with warming and are considered central thermoreceptors. Electrophysiologic and pharmacologic experiments have provided descriptions of their characteristics and signaling mechanisms. These studies have also allowed insights into the mechanisms by which neurochemicals important in thermoregulation exert their influence. Finally, the cellular mechanism involved in the interactions between thermoregulation and other aspects of homeostasis, such as energy metabolism and osmoregulation, have started to be unraveled.

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Authors: Tabarean, I. V.
Affiliations: Scintillon Institute (US)
Corresponding author: Iustin V. Tabarean
ORCID: Iustin V. Tabarean
Venue: Handbook of Clinical Neurology
Publisher: Elsevier
Published: 2018
Volume: 156
Pages: 121-127
ISSN: 0072-9752 (ISSN-L)
DOI: 10.1016/b978-0-444-63912-7.00007-2
OpenAlex: W4233709709
Cited by: 11
References: 55
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4
FWCI: 3.32
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Handbook of clinical neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: warm-sensitive neurons, preoptic area, anterior hypothalamus, thermoregulation, homeothermy, core body temperature, energy metabolism, osmoregulation
MeSH terms: Animals, Body Temperature Regulation, Brain, Homeostasis, Humans, Thermoreceptors

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