Single unit activity of anterior hypothalamus during local heating
Abstract
There are heat-sensitive units in the anterior hypothalamus which respond with an increase of discharge frequency to a rise in hypothalamic temperature of less than 1 degrees C. The increase of unit discharge occurred in advance of the onset of polypnea , and the unit has little phasic response or after discharge, and shows little adaptation.
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Thermosensitive neurons that participate in physiological thermoregulation are predominantly warm-sensitive cells located mostly in the preoptic hypothalamus.
“Thermosensitive neurons that do participate in physiological thermoregulation are predominantly warm-sensitive cells located mostly in the preoptic hypothalamus (Boulant, 2000; Nakayama et al., 1961).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Nakayama et al., 1961
Cites
ACTIVATION OF HEAT LOSS MECHANISMS BY LOCAL HEATING OF THE BRAIN
Magoun, H. W., Harrison, F., Brobeck, J. R., & Ranson, S. W. (1938) · Journal of Neurophysiology · doi:10.1152/jn.1938.1.2.101 · Cited by 263 · see citing works
Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs
Hammel, H. T., Hardy, J. D., & Fusco, M. M. (1960) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1960.198.3.481 · Cited by 218 · see citing works
Self-citationHYPOTHALAMIC REGULATION OF BODY TEMPERATURE
Clark, G. A., Magoun, H. W., & Ranson, S. W. (1939) · Journal of Neurophysiology · doi:10.1152/jn.1939.2.1.61 · Cited by 120 · see citing works
Central Control of Heat Loss Mechanisms in the Gost.
Andersson, B., GRANT, R., & LARSSON, S. (1956) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1956.tb01362.x · Cited by 77 · see citing works
Slow “temperature potentialss” in the hypothalamus
von Euler, C. (1950) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030360303 · Cited by 53 · see citing works
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Central circuitries for body temperature regulation and fever
Nakamura, K. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00109.2011 · Cited by 543 · see citing works
Warm-Sensitive Neurons that Control Body Temperature
Tan, C. L., Cooke, E. K., Leib, D. E., Lin, Y.-C., Daly, G. E., Zimmerman, C. A., & Knight, Z. A. (2016) · Cell · doi:10.1016/j.cell.2016.08.028 · Cited by 402 · see citing works
Rance, N. E., Dacks, P. A., Mittelman-Smith, M. A., Romanovsky, A. A., & Krajewski-Hall, S. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.003 · Cited by 380 · see citing works
Action of progesterone on preoptic thermosensitive neurones
NAKAYAMA, T., SUZUKI, M., & ISHIZUKA, N. (1975) · Nature · doi:10.1038/258080a0 · Cited by 113 · see citing works
Self-citationActivation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake
Jeong, J. H., Lee, D. K., Liu, S.-M., Chua, S. C., Schwartz, G. J., & Jo, Y.-H. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2004399 · Cited by 89 · see citing works
Roles of two preoptic cell groups in tonic and febrile control of rat tail sympathetic fibers
Tanaka, M., McKinley, M. J., & McAllen, R. M. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.91010.2008 · Cited by 60 · see citing works
(2018) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-63912-7.00007-2 · Cited by 11 · see citing works
- Authors
- Nakayama, T., Eisenman, J. S., & Hardy, J. D.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Science
- Published
- 1961-08-25
- Volume
- 134
- Issue
- 3478
- Pages
- 560-561
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993531577
- Cited by
- 214
- References
- 5
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 12 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 10 · 2013: 5 · 2012: 5
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Keywords
- anterior hypothalamus, single-unit activity, hypothalamic temperature, local heating, polypnea, neuronal discharge rate, thermal adaptation, thermoregulation
- MeSH terms
- Acclimatization, Body Temperature, Heating, Hypothalamus, Hypothalamus, Anterior, Temperature
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