Tau proteinopathies and the prion concept
Abstract
The ordered assembly of a small number of proteins into amyloid filaments is central to age-related neurodegenerative diseases. Tau is the most commonly affected of these proteins. In sporadic diseases, assemblies of tau form in a stochastic manner in certain brain regions, from where they appear to spread in a deterministic way, giving rise to disease symptoms. Over the past decade, multiple lines of evidence have shown that assembled tau behaves like a prion. More recently, electron cryo-microscopy of tau filaments has shown that distinct conformers are present in different diseases, with no inter-individual variation for a given disease.
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Short fibrils and oligomers of tau can transfer from one neuron to another and spread pathology throughout the brain in a prion-like manner.
“Over the past several years, it has become increasingly evident that short fibrils and oligomers of tau can transfer from one neuron to another and thereby spread pathology throughout the brain in a prion-like manner (4, 5, 6).”
From MAP2 caps tau fibrils and inhibits aggregation (2023) · cites this paper as [5]
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The <scp>NLRP3</scp> inflammasome modulates tau pathology and neurodegeneration in a tauopathy model
Stancu, I. C., Lodder, C., Botella Lucena, P., Vanherle, S., Gutiérrez de Ravé, M., Terwel, D., Bottelbergs, A., & Dewachter, I. (2022) · Glia · doi:10.1002/glia.24160 · Cited by 72 · see citing works
MAP2 caps tau fibrils and inhibits aggregation
Holden, M. R., Krzesinski, B. J., Weismiller, H. A., Shady, J. R., & Margittai, M. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104891 · Cited by 13 · see citing works
- Authors
- Goedert, M.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Michel Goedert
- ORCID
- Michel Goedert
- Venue
- Progress in Molecular Biology and Translational Science
- Publisher
- Elsevier
- Published
- 2020
- Volume
- 175
- Pages
- 239-259
- ISSN
- 1877-1173 (ISSN-L)
- OpenAlex
- W3084416161
- Cited by
- 38
- References
- 21
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 7
- FWCI
- 23.76
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in molecular biology and translational science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- tau protein, prion-like behavior, neurodegenerative diseases, tau filaments, disease spread
- MeSH terms
- Amino Acid Sequence, Animals, Brain, Humans, Phenotype, Prions, tau Proteins, Neurodegenerative Diseases, Tauopathies
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