Cited by 230Alzheimer's disease research and treatmentsTraumatic Brain Injury ResearchDementia and Cognitive Impairment Research

Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease

Schmidt, M., Zhukareva, V., Newell, K., Lee, V., Trojanowski, J.·2001·Acta Neuropathologica

Abstract

Insights into mechanisms of familial Alzheimer's disease (AD) caused by genetic mutations have emerged rapidly compared to sporadic AD. Indeed, despite identification of several sporadic AD risk factors, it remains enigmatic how or why they predispose to neurodegenerative disease. For example, traumatic brain injury (TBI) predisposes to AD, and recurrent TBI in career boxers may cause a progressive memory disorder associated with AD-like brain pathology known as dementia pugilistica (DP). Although the reasons for this are unknown, repeated TBI may cause DP by mechanisms similar to those involved in AD. To investigate this possibility, we compared the molecular profile of tau pathologies in DP with those in AD and showed that the same tau epitopes map to filamentous tau inclusions in AD and DP brains, while the abnormal tau proteins isolated from DP brains are indistinguishable from the six abnormally phosphorylated brain tau isoforms in AD brains. Thus, these data suggest that recurrent TBI may cause DP by activating pathological mechanisms similar to those that cause brain degeneration due to accumulations of filamentous tau lesions in AD, and similar, albeit attenuated, activation of these processes by a single TBI may increase susceptibility to sporadic AD decades after the event.

Integrity signals

Registry

Crossref · 10.1007/s004010000330

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • CTE is similar to AD in its tau isoform profile and phosphorylation state, and neuronal tau pathology is immunoreactive to both 3R and 4R tau.

    “CTE is similar to AD in its tau isoform profile and phosphorylation state [165], and neuronal tau pathology is immunoreactive to both 3R and 4R tau [128].”

    From The neuropathology of sport (2014) · cites this paper as [165]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Schmidt, M., Zhukareva, V., Newell, K., Lee, V., & Trojanowski, J.
Affiliations
  • University of Pennsylvania (US)
  • Hospital of the University of Pennsylvania (US)
  • Harvard University (US)
Corresponding author
Trojanowski, J.
Venue
Acta Neuropathologica
Published
2001-05
Volume
101
Issue
5
Pages
518-524
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
OpenAlex
W1585890093
Cited by
230
References
26
Citations by year
2026: 4 · 2025: 6 · 2024: 10 · 2023: 13 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 12 · 2018: 15 · 2017: 19 · 2016: 17 · 2015: 17 · 2014: 11 · 2013: 14 · 2012: 11
FWCI
2.39
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Massachusetts General Hospital
  • National Institutes of Health
  • National Institute on Aging (AG09215, P30AG010124, P01AG009215, AG-10124)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
chronic traumatic encephalopathy, tau isoforms, tau phosphorylation, Alzheimer's disease, traumatic brain injury, boxers, tau pathology, sporadic Alzheimer's disease, memory disorders, neurodegeneration
MeSH terms
Aged, Alzheimer Disease, Epitopes, Athletic Injuries, Boxing, Brain Injuries, Central Nervous System, Humans, Immunohistochemistry, Male, Neurons, Phosphorylation, Blotting, Western, Neurofibrillary Tangles, tau Proteins, Protein Isoforms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review