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Cited by 3Epigenetics and DNA MethylationChromosomal and Genetic VariationsCancer-related molecular mechanisms research

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Epigenetic and experimental approaches influencing non-coding RNAs

Urvashi Vijay, Ashmeet Kaur, Sunil Kumar Polipalli·2025·Progress in Molecular Biology and Translational Science
DOI 10.1016/bs.pmbts.2025.05.001
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Abstract

Epigenetics having sundry ambiences which are robustly linked to non-coding RNAs, precisely small RNAs that are generally imputated in gene expression regulation and helps in directing cytosine methylation and histone modifications of complex organisms. A pivotal peculiarity of epigenetics is that the same genome shows unwonted phenotypes which are situated in different epigenetics states. In last decade, the majority tangled epigenetic phenomena studied encompasses transposon activity and silencing which are directly or indirectly associated in RNA component and are currently epitomize by piRNAs (piwi-interacting RNAs), position effect variegation, X-chromosome inactivation, parental imprinting, and paramutation. Envisagly, there are certain non - coding RNAs are players in epigenetics gene regulation but their mechanism is still underlying. In yeast, plants, and mice, ncRNAs facilitate the inheritance of epigenetic states, effectively transmitting information across generations. This transgenerational epigenetic inheritance underscores the potential of ncRNAs to act as carriers of heritable information, bridging the gap between environmental cues and genetic responses. In conclusion, ncRNAs play a central role in epigenetic regulation and the transfer of genetic information, highlighting their importance in the evolution and complexity of higher organisms. In this review article, ongoing research continues to uncover the multifaceted functions of these molecules, offering deeper insights into the regulatory architectures that underpin life.

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Metadata

Authors
Vijay, U., Kaur, A., & Polipalli, S. K.
Affiliations
  • SMS Medical College (IN)
  • Amrita Vishwa Vidyapeetham (IN)
Corresponding author
Urvashi Vijay
ORCID
Venue
Progress in Molecular Biology and Translational Science
Publisher
Elsevier
Published
2025
Volume
214
Pages
65-79
ISSN
1877-1173 (ISSN-L)
DOI
10.1016/bs.pmbts.2025.05.001
OpenAlex
W4411049620
Cited by
3
References
1
Citations by year
2026: 3
FWCI
6.38
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Progress in molecular biology and translational science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
non-coding RNA, small RNA, epigenetics, gene expression regulation, cytosine methylation, histone modifications, transposon silencing, piRNA, position effect variegation, X chromosome inactivation, genomic imprinting, paramutation, transgenerational epigenetic inheritance, epigenetic inheritance
MeSH terms
Animals, Humans, RNA, Untranslated, Epigenesis, Genetic

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