Genomic DNA methylation: the mark and its mediators.

Klose, Robert J.; Bird, Adrian P.

doi:10.1016/j.tibs.2005.12.008

Cited by 2,501Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

Genomic DNA methylation: the mark and its mediators.

Klose, Robert J., Bird, Adrian P.·2006·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2005.12.008

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Abstract

Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essential for embryonic viability. With several of the key proteins now known, it has become possible to approach the biological significance of this epigenetic system through both biochemistry and genetics. As a result, advances have been made in our understanding of the mechanisms by which DNA methylation is targeted to specific regions of the genome and interpreted by methyl-CpG-binding proteins. Recent studies have illuminated the role of DNA methylation in controlling gene expression and have strengthened its links with histone modification and chromatin remodelling.

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“Corepressor complexes cause gene repression through the additional recruitment of HDACs, which deacetylate histones leading to condensation of the chromatin and gene silencing (45).”
From The Nuclear Receptor Corepressor Has Organizational Effects within the Developing Amygdala on Juvenile Social Play and Anxiety-Like Behavior (2010) · cites this paper as [45]

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Authors: Klose, R. J., & Bird, A. P.
Affiliations: Wellcome Centre for Cell Biology (GB)
Corresponding author: Bird, Adrian P.
ORCID: Klose, Robert J.
Bird, Adrian P.
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2006-02
Volume: 31
Issue: 2
Pages: 89-97
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2005.12.008
OpenAlex: W2152497434
Cited by: 2,501
References: 7
Citations by year: 2026: 29 · 2025: 36 · 2024: 61 · 2023: 83 · 2022: 67 · 2021: 87 · 2020: 90 · 2019: 142 · 2018: 137 · 2017: 154 · 2016: 146 · 2015: 158 · 2014: 177 · 2013: 186 · 2012: 187
FWCI: 11.25
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: DNA methylation, CpG, methyl-CpG binding proteins, DNA methyltransferases, epigenetic regulation, gene expression, histone modifications, chromatin remodeling, embryonic development, genomic imprinting
MeSH terms: Animals, DNA (Cytosine-5-)-Methyltransferases, DNA-Binding Proteins, Gene Expression Regulation, Humans, Intestinal Neoplasms, Transcription Factors, Transcription, Genetic, Rett Syndrome, CpG Islands, DNA Methylation, Gene Silencing, Epigenesis, Genetic, Methyl-CpG-Binding Protein 2

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Genomic DNA methylation: the mark and its mediators.

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