Thyroid Hormone Transport and Transporters
Abstract
Thyroid hormones orchestrate developmental processes and are among the most important regulators of energy metabolism. Thyroid hormone actions are mostly, but not exclusively, mediated by nuclear hormone receptors. As amino acid derivatives, thyroid hormones need plasma membrane transporters in order to reach their nuclear receptors. Several transporters from different gene families mediate thyroid hormone uptake into cells. Monocarboxylate transporter 8 is a specific thyroid hormone transporter found mutated in patients with severe psychomotor retardation and strangely abnormal thyroid hormone constellations. These patients display a syndrome in which some organs are exposed to increased thyroid hormone signaling, while other organs are lacking thyroid hormone signaling due to complete lack of thyroid hormone uptake. Investigations in many organ systems using mouse models of thyroid hormone transmembrane transporter deficiency have helped complete our picture of thyroid hormone metabolism and action in the body during development and under different physiological conditions. Incorporating the concept of thyroid hormone transmembrane transport has helped understand previously enigmatic drug interactions and may explain how the hormonal set points in the hypothalamus-pituitary-thyroid axis are established.
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Classical thyroid hormone transporters such as MCT8, MCT10, OATP, and LATs typically show low transport activity for 3,5-T2 compared to T4, T3, or 3,3′-T2.
“the classical transporters for thyroid hormones such as MCT8, MCT10, OATP, and LATs typically show low transport activity for 3,5-T2 compared to the other T4, T3, or 3,3′-T2”
From 3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action (2020) · cites this paper as [102]
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- Authors
- Braun, D., & Schweizer, U.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Schweizer, Ulrich
- Venue
- Vitamins and Hormones
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 106
- Pages
- 19-44
- ISSN
- 0083-6729 (ISSN-L)
- OpenAlex
- W2625057776
- Cited by
- 74
- References
- 12
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 8 · 2020: 11 · 2019: 6
- FWCI
- 17.48
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Vitamins and hormones (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Keywords
- thyroid hormone transport, thyroid hormone transporters, MCT8, thyroid hormone uptake, nuclear receptors, psychomotor retardation, thyroid hormone metabolism, drug interactions, hypothalamic-pituitary-thyroid axis, energy metabolism, developmental regulation
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Protein Binding, Thyroid Hormones, Protein Transport, Membrane Transport Proteins
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