Dehydroepiandrosterone and Cardiovascular Disease

Mannella, P.; Simoncini, T.; Caretto, M.; Genazzani, A.R.

doi:10.1016/bs.vh.2018.05.001

Cited by 24Hormonal and reproductive studiesHormonal Regulation and HypertensionEstrogen and related hormone effects

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Dehydroepiandrosterone and Cardiovascular Disease

Mannella, P., Simoncini, T., Caretto, M., Genazzani, A.R.·2018·Vitamins and hormones

DOI 10.1016/bs.vh.2018.05.001

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Abstract

The dehydroepiandrosterone and its metabolite, dehydroepiandrosterone sulfate, have been for a long while at the center of interest for endocrinologists and cardiologists. Consolidated data show that the dehydroepiandrosterone and the dehydroepiandrosterone sulfate present protective actions on the cardiovascular system. These actions are accomplished directly through target tissues such as endothelial cells, smooth muscle cells, and cardiomyocytes. At this level, they are able to activate a complex group of receptor, not completely identified, which modulate important functions such as vasodilation, antiinflammation, and antithrombosis. These data support the hypothesis that dehydroepiandrosterone could be used as drug for primary prevention of cardiovascular disease especially during aging and potentially also in addition of the common therapeutic strategy for the treatment and prevention of cardiovascular disease recurrence. In this publication, the effects of dehydroepiandrosterone and dehydroepiandrosterone sulfate on the cardiovascular system have been elucidated, starting with an analysis of the molecular action at target organ levels. In the second part, we evaluated the clinical effects of this administration, considering ultimately possible implications in introducing this hormone into clinical practice.

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DHEA-S serves as a large stable plasma reservoir for later conversion to DHEA.
“DHEA-S essentially serves as a large and stable plasma reservoir for later conversion to DHEA.42”
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Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
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Authors: Mannella, P., Simoncini, T., Caretto, M., & Genazzani, A. R.
Affiliations: University of Pisa (IT)
Corresponding author: Genazzani, A.R.
ORCID: Mannella, P.
Simoncini, T.
Caretto, M.
Genazzani, A.R.
Venue: Vitamins and hormones
Publisher: Elsevier
Published: 2018
Volume: 108
Pages: 333-353
ISSN: 0083-6729 (ISSN-L)
DOI: 10.1016/bs.vh.2018.05.001
OpenAlex: W2883571032
Cited by: 24
References: 50
Citations by year: 2026: 4 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 1
FWCI: 13.27
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Vitamins and hormones (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: dehydroepiandrosterone, dehydroepiandrosterone sulfate, cardiovascular disease, cardioprotection, endothelial cells, smooth muscle cells, cardiomyocytes, hormone receptors, vasodilation, anti-inflammatory activity, antithrombotic activity, primary prevention, aging
MeSH terms: Cardiovascular Diseases, Cardiovascular Physiological Phenomena, Dehydroepiandrosterone, Gene Expression Regulation, Humans, Dehydroepiandrosterone Sulfate

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Dehydroepiandrosterone and Cardiovascular Disease

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