Intervention against the Maillard reaction in vivo
Abstract
The field of Maillard/glycation reactions in vivo has grown enormously during the past 20 years, going from 25 to 500 publications per year. It is now well recognized that many of the "advanced" products form oxidatively or anaerobically and can have deleterious effects on macromolecular and biological function. The feasibility of developing pharmacological agents with beneficial in vivo properties, based on in vitro inhibition of glycation, has been surprisingly successful. This Editorial sets the stage for a series of articles by experts in the field, who have made key contributions to our understanding of the Maillard reaction in vivo.
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Higher iron intake, especially haem iron, and higher iron status are associated with increased risk of type 2 diabetes, atherosclerosis and coronary heart disease, although the literature is not fully consistent.
“There is some epidemiological evidence that higher Fe intake, particularly that of haem Fe, and higher Fe status are associated with increased risk of type 2 diabetes, atherosclerosis and CHD (702 -714) , although not all of the literature is consistent.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [705]
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References 162 · Cited by 196
- Authors
- Monnier, V. M.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Monnier, Vincent M.
- ORCID
- Monnier, Vincent M.
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 419
- Issue
- 1
- Pages
- 1-15
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2049374654
- Cited by
- 196
- References
- 162
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 16 · 2014: 16 · 2013: 10 · 2012: 21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- Maillard reaction, glycation, advanced glycation end products, glycation inhibitors, pharmacological agents, oxidative stress, macromolecular damage
- MeSH terms
- Aging, Animals, Diabetes Mellitus, Humans, Inflammation, Kidney Failure, Chronic, Oxidation-Reduction, Maillard Reaction, Glycation End Products, Advanced, Diabetes Complications
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