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Oxidation of amines by flavoproteins
Open accessAbstract
Many flavoproteins catalyze the oxidation of primary and secondary amines, with the transfer of a hydride equivalent from a carbon -nitrogen bond to the flavin cofactor. Most of these amine oxidases can be classified into two structural families, the D -amino acid oxidase/sarcosine oxidase family and the monoamine oxidase family. This review discusses the present understanding of the mechanisms of amine and amino acid oxidation by flavoproteins, focusing on these two structural families.
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Cites
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
Cited by
ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
Snezhkina, A. V., Kudryavtseva, A. V., Kardymon, O. L., Savvateeva, M. V., Melnikova, N. V., Krasnov, G. S., & Dmitriev, A. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6175804 · Cited by 934
Flavin dependent monooxygenases
Huijbers, M. M. E., Montersino, S., Westphal, A. H., Tischler, D., & van Berkel, W. J. H. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.12.005 · Cited by 527
The Concise Guide to PHARMACOLOGY 2013/14: Enzymes
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12451 · Cited by 425
Behl, T., Kaur, D., Sehgal, A., Singh, S., Sharma, N., Zengin, G., Andronie-Cioara, F. L., Toma, M. M., Bungau, S., & Bumbu, A. G. (2021) · Molecules · doi:10.3390/molecules26123724 · Cited by 317
Structures and mechanism of the monoamine oxidase family
Gaweska, H., & Fitzpatrick, P. F. (2011) · bmc · doi:10.1515/bmc.2011.030 · Cited by 247
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Metadata
- Authors
- Fitzpatrick, P. F.
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 493
- Issue
- 1
- Pages
- 13-25
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2021265316
- Cited by
- 219
- References
- 1
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- green
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