Cited by 934Redox biology and oxidative stressCancer and biochemical researchAntioxidant Activity and Oxidative Stress

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

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Snezhkina, Anastasiya V., Kudryavtseva, Anna V., Kardymon, Olga L., Savvateeva, Maria V., Melnikova, Nataliya V., Krasnov, George S., Dmitriev, Alexey A.·2019·Oxidative Medicine and Cellular Longevity

Abstract

Reactive oxygen species (ROS) are by-products of normal cell activity. They are produced in many cellular compartments and play a major role in signaling pathways. Overproduction of ROS is associated with the development of various human diseases (including cancer, cardiovascular, neurodegenerative, and metabolic disorders), inflammation, and aging. Tumors continuously generate ROS at increased levels that have a dual role in their development. Oxidative stress can promote tumor initiation, progression, and resistance to therapy through DNA damage, leading to the accumulation of mutations and genome instability, as well as reprogramming cell metabolism and signaling. On the contrary, elevated ROS levels can induce tumor cell death. This review covers the current data on the mechanisms of ROS generation and existing antioxidant systems balancing the redox state in mammalian cells that can also be related to tumors.

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Crossref · 10.1155/2019/6175804

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  • In addition to mitochondria, ROS are produced by a variety of enzymes such as NOx, xanthine oxidase, nitric oxide synthase NOS, and in other cell organelles such as the endoplasmic reticulum, peroxisomes, and cytosol.

    “In addition to mitochondria, ROS are produced by a variety of enzymes such as NOx, xanthine oxidase, nitric oxide synthase NOS, and in other cell organelles such as the endoplasmic reticulum, peroxisomes, and cytosol [11].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [11]

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Authors
Snezhkina, A. V., Kudryavtseva, A. V., Kardymon, O. L., Savvateeva, M. V., Melnikova, N. V., Krasnov, G. S., & Dmitriev, A. A.
Affiliations
Engelhardt Institute of Molecular Biology (RU)
Corresponding author
  • Snezhkina, Anastasiya V.
  • Dmitriev, Alexey A.
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2019-08-05
Volume
2019
Pages
1-17
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2966094674
Cited by
934
References
277
Citations by year
2026: 84 · 2025: 136 · 2024: 161 · 2023: 155 · 2022: 177 · 2021: 129 · 2020: 83 · 2019: 8
FWCI
8.81
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Russian Science Foundation (17-74-20064, 17-75-20105)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
reactive oxygen species, antioxidant defense, oxidative stress, cancer, tumor progression, DNA damage, genomic instability, redox signaling, cancer cell death, treatment resistance, inflammation, aging
MeSH terms
Antioxidants, Cell Count, Cell Transformation, Neoplastic, Humans, Reactive Oxygen Species

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