The Keap1-Nrf2 system and diabetes mellitus

Uruno, Akira, Yagishita, Yoko, Yamamoto, Masayuki·2015·Archives of Biochemistry and Biophysics

Cited by (231)

Items 101–200 of 231

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  3. Nrf2, a novel molecular target to reduce type 1 diabetes associated secondary complications: The basic considerations
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  4. Effects of Compound Centella on Oxidative Stress and Keap1‐Nrf2‐ARE Pathway Expression in Diabetic Kidney Disease Rats
    Zhu, Qin, Zeng, Jiali, Li, Jian, Chen, Xueming, Miao, Jianxia, Jin, Qinyang, Chen, Hongyu · 2020 · Evidence-Based Complementary and Alternative Medicine
  5. Identification of the Nrf2 in the fathead minnow muscle cell line: role for a regulation in response to H2O2 induced the oxidative stress in fish cell
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  6. Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage
    Karin J. Bosma, Spencer R. Andrei, Liora S. Katz, Ashley A. Smith, Jennifer C. Dunn, VALERIE F. RICCIARDI, Marisol Adelina Ramirez, Sharon Baumel-Alterzon, William A. Pace, Darian T. Carroll et al. · 2021 · Molecular Metabolism
  7. Hypoxia preconditioning promotes endurance exercise capacity of mice by activating skeletal muscle Nrf2
    Linjia Wang, Simin Yang, Lu Yan, Wei Hao, Jianxiong Wang, Siwang Yu, Ah‐Ng Tony Kong, Ying Zhang · 2019 · Journal of Applied Physiology
  8. High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression
    Xiangyuan Chen, Jie Qi, Qichao Wu, Hui Jiang, Jing Wang, Wankun Chen, Anrong Mao, Minmin Zhu · 2020 · Acta Biochimica et Biophysica Sinica
  9. The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer’s disease, type 2 diabetes, and type 2 diabetes-related Alzheimer’s disease
    Ling He, Yi Sun · 2021 · Metabolic Brain Disease
  10. Emerging Role of LncRNA Regulation for NLRP3 Inflammasome in Diabetes Complications
    Xiaolin Lü, Qihong Tan, Jianyong Ma, Jing Zhang, Peng Yu · 2022 · Frontiers in Cell and Developmental Biology
  11. Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model
    Deborah Amos, Carla R. Cook, Nalini Santanam · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  12. Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice
    Vanessa Angonesi Zborowski, Suélen O. Heck, Marina Vencato, Simone Pinton, Luiza Souza Marques, Cristina Wayne Nogueira · 2019 · Psychopharmacology
  13. Potentials of natural antioxidants from plants as antiosteoporotic agents
    Eiko Sakai, Fatima Farhana, Yu Yamaguchi, Takayuki Tsukuba · 2022 · Studies in natural products chemistry
  14. Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2
    Xiaohui Sun, Mingxin Dong, Yu Gao, Yan Wang, Liqing Du, Yang Liu, Qin Wang, Kaihua Ji, Ningning He, Jinhan Wang et al. · 2022 · Biochemical Pharmacology
  15. Potential Clinical Applications of Ozone Therapy in Dental Specialties—A Literature Review, Supported by Own Observations
    Izabela Barczyk, Diana Masłyk, Natalia Walczuk, Karina Kijak, Piotr Skomro, Helena Gronwald, Maria Pawlak, Angelika Rusińska, Natalia Sadowska, Barbara Janina Gronwald et al. · 2023 · International Journal of Environmental Research and Public Health
  16. Methylglyoxal disturbs the expression of antioxidant, apoptotic and glycation responsive genes and triggers programmed cell death in human leukocytes
    Alessandro de Souza Prestes, Matheus Mülling dos Santos, Assis Ecker, Gabriel Teixeira de Macedo, Roselei Fachinetto, Getúlio Nicola Bressan, João Batista Teixeira da Rocha, Nilda Vargas Barbosa · 2018 · Toxicology in Vitro
  17. SIRT1: Mechanism and Protective Effect in Diabetic Nephropathy
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  18. Coenzyme Q10: A Key Antioxidant in the Management of Diabetes-Induced Cardiovascular Complications—An Overview of Mechanisms and Clinical Evidence
    Fatemeh Samimi, Nasim Namiranian, Ali Sharifi-Rigi, Morvarid Siri, Omid Abazari, Sanaz Dastghaib · 2024 · International Journal of Endocrinology
  19. Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor
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  20. Plin5, a New Target in Diabetic Cardiomyopathy
    Xiangning Cui, Jingwu Wang, Yang Zhang, Jian-Liang Wei, Yan Wang · 2022 · Oxidative Medicine and Cellular Longevity
  21. Increased placental expressions of nuclear factor erythroid 2–related factor 2 and antioxidant enzymes in gestational diabetes: Protective mechanisms against the placental oxidative stress?
    Balachandiran Manoharan, Zachariah Bobby, Gowri Dorairajan, Sajini Elizabeth Jacob, Victorraj Gladwin, Vickneshwaran Vinayagam, Rajaa Muthu Packirisamy · 2019 · European Journal of Obstetrics & Gynecology and Reproductive Biology
  22. Nrf2 plays a critical role in the metabolic response during and after spaceflight
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  23. Genetic Variations on Redox Control in Cardiometabolic Diseases: The Role of Nrf2
    Cecilia Zazueta, Alexis Paulina Jiménez‐Uribe, José Pedraza‐Chaverrí, Mabel Buelna‐Chontal · 2022 · Antioxidants
  24. Smooth muscle‐generated methylglyoxal impairs endothelial cell‐mediated vasodilatation of cerebral microvessels in type 1 diabetic rats
    Fadhel A. Alomar, Jaipaul Singh, Hee‐Seong Jang, George J Rozanzki, Chun Hong Shao, Babu J. Padanilam, William G. Mayhan, Keshore R. Bidasee · 2016 · British Journal of Pharmacology
  25. Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene
    Franklyn Nonso Iheagwam, Gaber El‐Saber Batiha, Olubanke Olujoke Ogunlana, Shalom Nwodo Chinedu · 2021 · International Journal of Inflammation
  26. Betanin alleviates oxidative stress through the Nrf2 signaling pathway in the liver of STZ-induced diabetic rats
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  27. Metabolic Syndrome, Redox State, and the Proteasomal System
    Annika Höhn, Jeannette König, Tobias Jung · 2016 · Antioxidants and Redox Signaling
  28. m-Trifluoromethyl-diphenyl diselenide (m-CF3-PhSe)2 modulates the hippocampal neurotoxic adaptations and abolishes a depressive-like phenotype in a short-term morphine withdrawal in mice
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  29. The efficacy of Origanum majorana nanocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats
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  31. Dendrobium officinale polysaccharide decreases podocyte injury in diabetic nephropathy by regulating IRS-1/AKT signal and promoting mitophagy
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  32. Pterostilbene Reverses Epigenetic Silencing of Nrf2 and Enhances Antioxidant Response in Endothelial Cells in Hyperglycemic Microenvironment
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  33. Research for type 2 diabetes mellitus in endemic arsenism areas in central China: role of low level of arsenic exposure and KEAP1 rs11545829 polymorphism
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  34. Nrf2 in Type 2 diabetes and diabetic complications: Yin and Yang
    Jingqi Fu, Yongyong Hou, Peng Xue, Huihui Wang, Yuanyuan Xu, Weidong Qu, Qiang Zhang, Jingbo Pi · 2016 · Current Opinion in Toxicology
  35. Deciphering Intertwined Molecular Pathways Underlying Metabolic Syndrome Leading to Parkinson’s Disease
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  36. An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors
    Huawu Yin, Yen‐Hua Huang, Sarah A. Best, Kate D. Sutherland, David J. Craik, Conan K. L. Wang · 2021 · ACS Chemical Biology
  37. Allopurinol ameliorates liver injury in type 1 diabetic rats through activating Nrf2
    Fei Zeng, Jierong Luo, Hong Han, Wenjie Xie, Lingzhi Wang, Ronghui Han, Hao Chen, Yin Cai, Huansen Huang, Zhengyuan Xia · 2021 · International Journal of Immunopathology and Pharmacology
  38. Impact of different processing methods on the phenolics and neuroprotective activity of Fragaria ananassa Duch. extracts in a d -galactose and aluminum chloride-induced rat model of aging
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  39. Long-term diabetes causes molecular alterations related to fibrosis and apoptosis in rat urinary bladder
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  40. Compostos bioativos em alimentos, estresse oxidativo e inflamação: uma visão molecular da nutrição
    Elaine dos Ramos Soares, Elisa Bernardes Monteiro, Renata C. da Silva, Aline Batista, Flávia Sobreira Mendonça Gonçalves, Thaísa Mattos, Cristiane Aguiar da Costa, Júlio Beltrame Daleprane · 2015 · Revista Hospital Universitário Pedro Ernesto
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  42. Association of single-nucleotide polymorphisms of the KEAP1 gene with the risk of various human diseases and its functional impact using in silico analysis
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  43. Probucol Prevents Diabetes‐Induced Retinal Neuronal Degeneration through Upregulating Nrf2
    Hengwei Liu, Yong Jun Luo, Yufan Zhou, Zhongping Chen · 2020 · BioMed Research International
  44. Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies
    Yunuo Yang, Jiaxuan Wu, Wenjun Zhou, Guang Ji, Yanqi Dang · 2024 · MedComm
  45. Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases
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  46. Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2/HO-1 axis
    Peng Liu, Baige Cao, Yang Zhou, Huina Zhang, Congrong Wang · 2023 · Journal of Molecular Cell Biology
  47. HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model
    Jimin Kim, Su‐Hyun Shin, Jong‐Koo Kang, Jae Wha Kim · 2018 · Oncotarget
  48. Peanut Shell Extract Improves Mitochondrial Function in db/db Mice via Suppression of Oxidative Stress and Inflammation
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  49. Pinitol Improves Diabetic Foot Ulcers in Streptozotocin-Induced Diabetes Rats Through Upregulation of Nrf2/HO-1 Signaling
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  50. Looking into the possibilities of cure of the type 2 diabetes mellitus by nanoparticle-based RNAi and CRISPR-Cas9 system: A review
    Payal Roy, Suman Saha, Jui Chakraborty · 2021 · Journal of Drug Delivery Science and Technology
  51. Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats
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  52. Vaccinium as Potential Therapy for Diabetes and Microvascular Complications
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  53. Functional Polymorphism in the NFE2L2 Gene Associated With Tuberculosis Susceptibility
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  54. Redox homeostasis and therapeutic modulation: the central role of oxidative stress and nuclear factor erythroid 2-related factor 2 (Nrf2) activation in systemic diseases and reproductive dysfunction
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  55. Role of oxidants and antioxidants in diabetic wound healing
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  56. Eicosapentaenoic acid prevents salt sensitivity in diabetic rats and decreases oxidative stress
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  59. Oxidative Stress in Diabetes
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  60. NRF2 deficiency increases obesity susceptibility in a mouse menopausal model
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  61. Oxidative stress: impact in redox biology and medicine
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  67. Phytochemical activators of Nrf2: a review of therapeutic strategy in diabetes
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