The Keap1-Nrf2 system and diabetes mellitus

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works

Mechanisms linking obesity to insulin resistance and type 2 diabetes

Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448 · see citing works

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224 · see citing works

H ₂ O ₂ , a Necessary Evil for Cell Signaling

Rhee, S. G. (2006) · Science · doi:10.1126/science.1130481 · Cited by 2,160 · see citing works

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,158 · see citing works

Changes in diabetes-related complications in the United States, 1990-2010

Gregg, E. W., Li, Y., Wang, J., Rios Burrows, N., Ali, M. K., Rolka, D., Williams, D. E., & Geiss, L. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1310799 · Cited by 1,749 · see citing works

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Rushmore, T. H., Morton, M. R., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99004-6 · Cited by 1,464 · see citing works

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,460 · see citing works

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415 · see citing works

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395 · see citing works

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

Alam, J., Stewart, D. P., Touchard, C. L., Boinapally, S., Choi, A. M. K., & Cook, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26071 · Cited by 1,284 · see citing works

Untitled work

(2002) · PubMed · Cited by 1,190 · see citing works

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues

Lenzen, S., Drinkgern, J., & Tiedge, M. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)02051-5 · Cited by 1,167 · see citing works

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

de Zeeuw, D., Akizawa, T., Audhya, P., Bakris, G. L., Chin, M. P., Christ‐Schmidt, H., Goldsberry, A., Houser, M. T., Krauth, M., Heerspink, H. J. L., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1306033 · Cited by 1,041 · see citing works

Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications

Sheetz, M. J. (2002) · JAMA · doi:10.1001/jama.288.20.2579 · Cited by 1,003 · see citing works

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

MAGIC, Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., et al. (2010) · Nature Genetics · doi:10.1038/ng.685 · Cited by 931 · see citing works

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

Pergola, P. E., Raskin, P., Toto, R. D., Meyer, C. J., Huff, J. W., Grossman, E. B., Krauth, M., Ruiz, S., Audhya, P., Christ-Schmidt, H., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105351 · Cited by 890 · see citing works

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., KOTSUJI, T., Otsuka, F., Roop, D. R., et al. (2003) · Nature Genetics · doi:10.1038/ng1248 · Cited by 881 · see citing works

Oxidative damage to DNA in diabetes mellitus

Dandona, P., Thusu, K., Cook, S., Snyder, B., Makowski, J., Armstrong, D., & Nicotera, T. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90013-6 · Cited by 788 · see citing works

Stress-activated cap’n’collar transcription factors in aging and human disease

Sykiotis, G. P., & Bohmann, D. (2010) · Science Signaling · doi:10.1126/scisignal.3112re3 · Cited by 776 · see citing works

SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D., & Cuadrado, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01204-10 · Cited by 759 · see citing works

Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

Tong, K. I., Katoh, Y., Kusunoki, H., Itoh, K., Tanaka, T., & Yamamoto, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2887-2900.2006 · Cited by 759 · see citing works

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

Padmanabhan, B., Tong, K. I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S., & Yamamoto, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.013 · Cited by 735 · see citing works

New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy

Ceriello, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1589 · Cited by 734 · see citing works

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

Enomoto, A. (2001) · Toxicological Sciences · doi:10.1093/toxsci/59.1.169 · Cited by 728 · see citing works

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., Hanafusa, T., Matsuzawa, Y., Yamasaki, Y., & Hori, M. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2398 · Cited by 713 · see citing works

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

Sakuraba, H., Mizukami, H., Yagihashi, N., Wada, R., Hanyu, C., & Yagihashi, S. (2002) · Diabetologia · doi:10.1007/s125-002-8248-z · Cited by 699 · see citing works

Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice

Cho, H., Jedlicka, A., Reddy, S. P., Kensler, T. W., Yamamoto, M. P., Zhang, L.-Y., & Kleeberger, S. R. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.2.4501 · Cited by 660 · see citing works

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A., & Hayes, J. D. (2013) · Oncogene · doi:10.1038/onc.2012.388 · Cited by 657 · see citing works

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

Kobayashi, M., Li, L., Iwamoto, N., Nakajima‐Takagi, Y., Kaneko, H., Nakayama, Y., Eguchi, M., Wada, Y., Kumagai, Y., & Yamamoto, M. P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01080-08 · Cited by 641 · see citing works

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D., & Zhang, D. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.029 · Cited by 638 · see citing works

Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion

Pi, J., Bai, Y., Zhang, Q., Wong, V. A., Floering, L. M., Daniel, K. W., Reece, J. M., Deeney, J. T., Andersen, M. E., Corkey, B. E., et al. (2007) · Diabetes · doi:10.2337/db06-1601 · Cited by 570 · see citing works

Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression

Sasaki, H., Sato, H., Kuriyama-Matsumura, K., Sato, K., Maebara, K., Wang, H., Tamba, M., Itoh, K., Yamamoto, M. P., & Bannai, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208704200 · Cited by 544 · see citing works

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A., & Yamamoto, M. P. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00469.x · Cited by 521 · see citing works

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse

Grankvist, K., Marklund, S. L., & Täljedal, I. ‐. (1981) · Biochemical Journal · doi:10.1042/bj1990393 · Cited by 517 · see citing works

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

Zheng, H., Whitman, S. A., Wu, W., Wondrak, G. T., Wong, P. K., Fang, D., & Zhang, D. D. (2011) · Diabetes · doi:10.2337/db11-0807 · Cited by 507 · see citing works

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

Ihara, Y., Toyokuni, S., Uchida, K., Odaka, H., Tanaka, T., Ikeda, H., Hiai, H., Seino, Y., & Yamada, Y. (1999) · Diabetes · doi:10.2337/diabetes.48.4.927 · Cited by 506 · see citing works

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.

Friling, R. S., Bensimon, A., Tichauer, Y., & Daniel, V. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6258 · Cited by 475 · see citing works

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I. P., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M. P., Dinkova‐Kostova, A. T., & Abramov, A. Y. (2013) · Biology Open · doi:10.1242/bio.20134853 · Cited by 451 · see citing works

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

Tong, K. I., Padmanabhan, B., Kobayashi, A., Shang, C., Hirotsu, Y., Yokoyama, S., & Yamamoto, M. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00753-07 · Cited by 447 · see citing works

Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins

Igarashi, K., Kataokat, K., Itoh, K., Hayashi, N., Nishizawa, M., & Yamamoto, M. (1994) · Nature · doi:10.1038/367568a0 · Cited by 444 · see citing works

Cloning and Characterization of a Novel Erythroid Cell-Derived CNC Family Transcription Factor Heterodimerizing with the Small Maf Family Proteins

Itoh, K., Igarashi, K., Hayashi, N., Nishizawa, M., & Yamamoto, M. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4184 · Cited by 438 · see citing works

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

Hirotsu, Y., Katsuoka, F., Funayama, R., Nagashima, T., Nishida, Y., Nakayama, K., Engel, J. D., & Yamamoto, M. P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks827 · Cited by 431 · see citing works

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

Tan, Y., Ichikawa, T., Li, J., Si, Q., Yang, H., Chen, X., Goldblatt, C. S., Meyer, C. J., Li, X., Cai, L., et al. (2011) · Diabetes · doi:10.2337/db10-1164 · Cited by 393 · see citing works

Glucose and diabetic vascular disease 1

Ruderman, N. B., Williamson, J. R., & Brownlee, M. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.11.1644256 · Cited by 375 · see citing works

Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway

Motohashi, H., Katsuoka, F., Engel, J. D., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305902101 · Cited by 363 · see citing works

Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion

Leloup, C., Tourrel-Cuzin, C., Magnan, C., Karaca, M., Castel, J., Carneiro, L., Colombani, A.-L., Ktorza, A., Casteilla, L., & Pénicaud, L. (2009) · Diabetes · doi:10.2337/db07-1056 · Cited by 361 · see citing works

The transcription factor NRF2 protects against pulmonary fibrosis

Cho, H., Reddy, S. P., Yamamoto, M. P., & Kleeberger, S. R. (2004) · The FASEB Journal · doi:10.1096/fj.03-1127fje · Cited by 355 · see citing works

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

Uruno, A., Furusawa, Y., Yagishita, Y., Fukutomi, T., Muramatsu, H., Negishi, T., Sugawara, A., Kensler, T. W., & Yamamoto, M. P. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00225-13 · Cited by 330 · see citing works

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells

Sakai, K., Matsumoto, K., Nishikawa, T., Suefuji, M., Nakamaru, K., Hirashima, Y., Kawashima, J., Shirotani, T., Ichinose, K., Brownlee, M., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02832-2 · Cited by 323 · see citing works

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

Ohtsuji, M., Katsuoka, F., Kobayashi, A., Aburatani, H., Hayes, J. D., & Yamamoto, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804597200 · Cited by 317 · see citing works

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

Pi, J., Leung, L., Xue, P., Wang, W., Hou, Y., Liu, D., Yehuda‐Shnaidman, E., Lee, C., Lau, J., Kurtz, T. W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.093955 · Cited by 299 · see citing works

Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

Kobayashi, A., Ito, E., Toki, T., Kogame, K., Takahashi, S., Igarashi, K., Hayashi, N., & Yamamoto, M. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6443 · Cited by 299 · see citing works

Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response Element-Dependent Genes

Katsuoka, F., Motohashi, H., Ishii, T., Aburatani, H., Engel, J. D., & Yamamoto, M. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8044-8051.2005 · Cited by 283 · see citing works

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

Takaya, K., Suzuki, T., Motohashi, H., Onodera, K., Satomi, S., Kensler, T. W., & Yamamoto, M. P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.023 · Cited by 277 · see citing works

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

Shin, S., Wakabayashi, J., Yates, M. S., Wakabayashi, N., Dolan, P. M., Aja, S. M., Liby, K. T., Sporn, M. B., Yamamoto, M. P., & Kensler, T. W. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.08.022 · Cited by 275 · see citing works

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

Hayashi, A., Suzuki, H., Itoh, K., Yamamoto, M. P., & Sugiyama, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.086 · Cited by 267 · see citing works

Impaired liver regeneration in Nrf2 knockout mice: role of ROS‐mediated insulin/IGF‐1 resistance

Beyer, T. A., Xu, W., Teupser, D., Keller, U. A. D., Bugnon, P., Hildt, E., Thiery, J., Kan, Y. W., & Werner, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601950 · Cited by 267 · see citing works

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., & Yamamoto, M. P. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01191-13 · Cited by 265 · see citing works

Targeting the pancreatic β-cell to treat diabetes

Vetere, A., Choudhary, A., Burns, S. M., & Wagner, B. K. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4231 · Cited by 253 · see citing works

Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

Kwak, M.-K., Egner, P. A., Dolan, P. M., Ramos‐Gómez, M., Groopman, J. D., Itoh, K., Yamamoto, M. P., & Kensler, T. W. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00190-7 · Cited by 241 · see citing works

Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells

Harmon, J. S., Stein, R. W., & Robertson, R. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410345200 · Cited by 234 · see citing works

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

Taguchi, K., Maher, J. M., Suzuki, T., Kawatani, Y., Motohashi, H., & Yamamoto, M. P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01591-09 · Cited by 225 · see citing works

NRF2 plays a protective role in diabetic retinopathy in mice

Xu, Z., Wei, Y., Gong, J., Cho, H., Park, J. K., Sung, E.-R., Hu, H., Wu, L., Eberhart, C. G., Handa, J. T., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3093-8 · Cited by 211 · see citing works

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2‐deficient mice

Yoh, K., Hirayama, A., Ishizaki, K., Yamada, A., Takeuchi, M., Yamagishi, S., Morito, N., Nakano, T., Ojima, M., Shimohata, H., et al. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01234.x · Cited by 207 · see citing works

Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF‐E2‐related factor‐2

Sakurai, A., Nishimoto, M., Himeno, S., Imura, N., Tsujimoto, M., Kunimoto, M., & Hara, S. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20246 · Cited by 207 · see citing works

Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

Yagishita, Y., Fukutomi, T., Sugawara, A., Kawamura, H., Takahashi, T., Pi, J., Uruno, A., & Yamamoto, M. P. (2013) · Diabetes · doi:10.2337/db13-0909 · Cited by 205 · see citing works

Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro

Grankvist, K., Marklund, S. L., Sehlin, J., & Täljedal, I. ‐. (1979) · Biochemical Journal · doi:10.1042/bj1820017 · Cited by 204 · see citing works

The Keap1–Nrf2 system as an in vivo sensor for electrophiles

Uruno, A., & Motohashi, H. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.02.007 · Cited by 187 · see citing works

Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice

Chartoumpekis, D. V., Ziros, P. G., Psyrogiannis, A. I., Papavassiliou, A. G., Kyriazopoulou, V. E., Sykiotis, G. P., & Habeos, I. G. (2011) · Diabetes · doi:10.2337/db11-0112 · Cited by 184 · see citing works

β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes in db/db Mice

Harmon, J. S., Bogdani, M., Parazzoli, S. D., Mak, S. S. M., Oseid, E. A., Berghmans, M., LeBoeuf, R. C., & Robertson, R. P. (2009) · Endocrinology · doi:10.1210/en.2009-0708 · Cited by 183 · see citing works

Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

Yu, Z., Shao, W., Chiang, Y., Foltz, W. D., Zhang, Z., Ling, W., Fantus, I. G., & Jin, T. (2010) · Diabetologia · doi:10.1007/s00125-010-2001-8 · Cited by 173 · see citing works

Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway

Song, M., Kim, E., Moon, W., Park, J., Kim, H., So, H., Park, R., Kwon, K., & Park, B. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.11.007 · Cited by 169 · see citing works

Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome

Xue, P., Hou, Y., Chen, Y., Yang, B., Fu, J., Zheng, H., Yarborough, K., Woods, C. G., Liu, D., Yamamoto, M. P., et al. (2012) · Diabetes · doi:10.2337/db12-0584 · Cited by 169 · see citing works

Superoxide dismutase is a prophylactic against alloxan diabetes

Grankvist, K., Marklund, S. L., & Täljedal, I. (1981) · Nature · doi:10.1038/294158a0 · Cited by 165 · see citing works

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

Sugimoto, H., Okada, K., Shoda, J., Warabi, E., Ishige, K., Ueda, T., Taguchi, K., Yanagawa, T., Nakahara, A., Hyodo, I., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00296.2009 · Cited by 160 · see citing works

Glucose availability is a decisive factor for Nrf2-mediated gene expression

Heiß, E. H., Schachner, D., Zimmermann, K., & Dirsch, V. M. (2013) · Redox Biology · doi:10.1016/j.redox.2013.06.001 · Cited by 157 · see citing works

Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress

Kubisch, H. M., Wang, J., Bray, T. Μ., & Phillips, J. P. (1997) · Diabetes · doi:10.2337/diabetes.46.10.1563 · Cited by 154 · see citing works

The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response

Fujii, S., Sawa, T., Ihara, H., Tong, K. I., Ida, T., Okamoto, T., Ahmed, K. A., Ishima, Y., Motohashi, H., Yamamoto, M. P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.145441 · Cited by 151 · see citing works

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H‐1,2‐dithiole‐3‐thione

Soriano, F. X., Léveillé, F., Papadia, S., Higgins, L. G., Varley, J. A., Baxter, P. S., Hayes, J. D., & Hardingham, G. E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05648.x · Cited by 144 · see citing works

Overexpression of catalase provides partial protection to transgenic mouse beta cells

Xu, B., Moritz, J. T., & Epstein, P. N. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00130-6 · Cited by 114 · see citing works

The GK Rat: A Prototype for the Study of Non-overweight Type 2 Diabetes

Portha, B., Giroix, M.-H., Tourrel‐Cuzin, C., Stunff, H. L., & Movassat, J. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-068-7_9 · Cited by 112 · see citing works

The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr Mice

Saha, P., Reddy, V. T., Konopleva, M. Y., Andreeff, M., & Chan, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.176545 · Cited by 107 · see citing works

New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome

Chartoumpekis, D. V., & Kensler, T. W. (2013) · Current Diabetes Reviews · doi:10.2174/1573399811309020005 · Cited by 104 · see citing works

NF-E2-Related Factor 1 (Nrf1) Serves as a Novel Regulator of Hepatic Lipid Metabolism through Regulation of the Lipin1 and PGC-1 β Genes

Hirotsu, Y., Hataya, N., Katsuoka, F., & Yamamoto, M. P. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06706-11 · Cited by 102 · see citing works

Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet

Zhang, Y.-K. J., Wu, K. C., Liu, J., & Klaassen, C. D. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.09.014 · Cited by 93 · see citing works

Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner

Mukai, E., Fujimoto, S., Sato, H., Oneyama, C., Kominato, R., Sato, Y., Sasaki, M., Nishi, Y., Okada, M., & Inagaki, N. (2010) · Diabetes · doi:10.2337/db10-0021 · Cited by 92 · see citing works

Protection of pancreatic beta-cells: Is it feasible?

Bonora, E. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.05.004 · Cited by 89 · see citing works

Chronic Resveratrol Treatment Protects Pancreatic Islets against Oxidative Stress in db/db Mice

Lee, Y. E., Kim, J.-W., Lee, E. M., Ahn, Y., Song, K., Yoon, K., Kim, H.-W., Park, C.-W., Li, G., Liu, Z., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050412 · Cited by 78 · see citing works

Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes

Tsujita, T., Peirce, V. J., Baird, L., Matsuyama, Y., Takaku, M., Walsh, S. V., Griffin, J. L., Uruno, A., Yamamoto, M. P., & Hayes, J. D. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00110-14 · Cited by 78 · see citing works

Control of the Intracellular Redox State by Glucose Participates in the Insulin Secretion Mechanism

Rebelato, E., Abdulkader, F., Curi, R., & Carpinelli, Â. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024507 · Cited by 73 · see citing works

Reactive Oxygen Species Stimulate Insulin Secretion in Rat Pancreatic Islets: Studies Using Mono-Oleoyl-Glycerol

Saadeh, M., Ferrante, T. C., Kane, A., Shirihai, O. S., Corkey, B. E., & Deeney, J. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030200 · Cited by 72 · see citing works

Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage

Yang, B., Fu, J., Zheng, H., Xue, P., Yarborough, K., Woods, C. G., Hou, Y., Zhang, Q., Andersen, M. E., & Pi, J. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.09.012 · Cited by 63 · see citing works

Embryonic Lethality and Fetal Liver Apoptosis in Mice Lacking All Three Small Maf Proteins

Yamazaki, H., Katsuoka, F., Motohashi, H., Engel, J. D., & Yamamoto, M. P. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06543-11 · Cited by 61 · see citing works

Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells

Lee, S., Hur, E.-G., Ryoo, I.-G., Jung, K.-A., Kwak, J., & Kwak, M. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.08.021 · Cited by 60 · see citing works

Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue

Xu, J., Donepudi, A. C., Moscovitz, J. E., & Slitt, A. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079841 · Cited by 56 · see citing works

Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity

Chin, M. P., Lee, C.-Y. I., Chuang, J.-C., Bumeister, R., Wigley, W. C., Sonis, S. T., Ward, K. W., & Meyer, C. J. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00387.2012 · Cited by 56 · see citing works

Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

Meher, A. K., Sharma, P. R., Lira, V. A., Yamamoto, M. P., Kensler, T. W., Yan, Z., & Leitinger, N. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.022 · Cited by 51 · see citing works

Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate–activated protein kinase–p70 ribosomal S6 kinase-1 pathway

Bae, E. J., Yang, Y. M., Kim, J. W., & Kim, S. G. (2007) · Hepatology · doi:10.1002/hep.21769 · Cited by 50 · see citing works

Transcription factor NF ‐E2‐related factor 1 impairs glucose metabolism in mice

Hirotsu, Y., Higashi, C., Fukutomi, T., Katsuoka, F., Tsujita, T., Yagishita, Y., Matsuyama, Y., Motohashi, H., Uruno, A., & Yamamoto, M. P. (2014) · Genes to Cells · doi:10.1111/gtc.12165 · Cited by 44 · see citing works

Low doses of hydrogen peroxide impair glucose-stimulated insulin secretion via inhibition of glucose metabolism and intracellular calcium oscillations

Rebelato, E., Abdulkader, F., Curi, R., & Carpinelli, Â. R. (2009) · Metabolism · doi:10.1016/j.metabol.2009.08.010 · Cited by 42 · see citing works

Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction

Sasaki, M., Fujimoto, S., Sato, Y., Nishi, Y., Mukai, E., Yamano, G., Sato, H., Tahara, Y., Ogura, K., Nagashima, K., et al. (2013) · Diabetes · doi:10.2337/db12-0903 · Cited by 38 · see citing works

Divergent Effects of Sulforaphane on Basal and Glucose-Stimulated Insulin Secretion in β-Cells: Role of Reactive Oxygen Species and Induction of Endogenous Antioxidants

Fu, J., Zhang, Q., Woods, C. G., Zheng, H., Yang, B., Qu, W., Andersen, M. E., & Pi, J. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1013-8 · Cited by 32 · see citing works

Targeting Nrf2 by dihydro‐CDDO‐trifluoroethyl amide enhances autophagic clearance and viability of β‐cells in a setting of oxidative stress

Li, W., Wu, W., Song, H., Wang, F., Li, H., Chen, L., Lai, Y., Janicki, J. S., Ward, K. W., Meyer, C. J., et al. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.046 · Cited by 32 · see citing works

Role of endogenous ROS production in impaired metabolism-secretion coupling of diabetic pancreatic β cells

Fujimoto, S., Mukai, E., & Inagaki, N. (2011) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2011.07.013 · Cited by 23 · see citing works

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J. D., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A., Kensler, T. W., et al. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0008-x · Cited by 1,474 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

Molecular basis of the Keap1–Nrf2 system

Suzuki, T., & Yamamoto, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.006 · Cited by 995 · see citing works

The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases

Tu, W., Wang, H., Li, S., Liu, Q., & Sha, H. (2018) · Aging and Disease · doi:10.14336/ad.2018.0513 · Cited by 712 · see citing works

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622 · see citing works

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

Cuadrado, A., Manda, G., Hassan, A., Alcaraz, M. J., Barbas, C., Daiber, A., Ghezzi, P., León, R., López, M. G., Oliva, B., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014753 · Cited by 632 · see citing works

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

Abed, D. A., Goldstein, M., Albanyan, H., Jin, H., & Hu, L. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.05.008 · Cited by 330 · see citing works

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

David, J. A., Rifkin, W. J., Rabbani, P. S., & Ceradini, D. J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/4826724 · Cited by 305 · see citing works

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

Yamada, T., Murata, D., Adachi, Y., Itoh, K., Kameoka, S., Igarashi, A., Kato, T., Araki, Y., Huganir, R. L., Dawson, T. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.014 · Cited by 286 · see citing works

Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway

Ding, X., Jian, T., Wu, Y., Zuo, Y., Li, J., Lv, H., Ma, L., Ren, B., Zhao, L., Li, W., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.018 · Cited by 258 · see citing works

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

Hasnain, S. Z., Prins, J. B., & McGuckin, M. A. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0232 · Cited by 254 · see citing works

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

Matzinger, M., Fischhuber, K., & Heiß, E. H. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.015 · Cited by 205 · see citing works

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

Mikhed, Y., Görlach, A., Knaus, U. G., & Daiber, A. (2015) · Redox Biology · doi:10.1016/j.redox.2015.05.008 · Cited by 181 · see citing works

Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice

Uruno, A., Matsumaru, D., Ryoke, R., Saito, R., Kadoguchi, S., Saigusa, D., Saito, T., Saido, T. C., Kawashima, R., & Yamamoto, M. P. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00467-19 · Cited by 166 · see citing works

Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process

Polaka, S., Katare, P., Pawar, B., Vasdev, N., Gupta, T., Rajpoot, K., Sengupta, P., & Tekade, R. K. (2022) · ACS Omega · doi:10.1021/acsomega.2c02675 · Cited by 166 · see citing works

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases

da Costa, R. M., Rodrigues, D., Pereira, C. A., da Silva, J. F., Alves, J. V., Lobato, N. S., & Tostes, R. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00382 · Cited by 165 · see citing works

Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway

Hosseini, H., Teimouri, M., Shabani, M., Koushki, M., Khorzoughi, R. B., Namvarjah, F., Izadi, P., & Meshkani, R. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105667 · Cited by 157 · see citing works

Pharmacotherapy of type 2 diabetes: An update and future directions

DeMarsilis, A. J., Reddy, N., Boutari, C., Filippaios, A., Sternthal, E., Katsiki, N., & Mantzoros, C. S. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155332 · Cited by 161 · see citing works

Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

Hung, P., Hsu, Y., Chen, T., & Lin, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111857 · Cited by 152 · see citing works

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress

Yagishita, Y., Uruno, A., Fukutomi, T., Saito, R., Saigusa, D., Pi, J., Fukamizu, A., Sugiyama, F., Takahashi, S., & Yamamoto, M. P. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.064 · Cited by 129 · see citing works

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

Uruno, A., Yagishita, Y., Katsuoka, F., Kitajima, Y., Nunomiya, A., Nagatomi, R., Pi, J., Biswal, S. S., & Yamamoto, M. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.01095-15 · Cited by 126 · see citing works

Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID‐19

Bousquet, J., Antó, J. M., Czarlewski, W., Haahtela, T., Fonseca, S. C., Iaccarino, G., Blain, H., Vidal, A., Sheikh, A., Akdiş, C. A., et al. (2020) · Allergy · doi:10.1111/all.14549 · Cited by 122 · see citing works

Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection Severity

Mendonca, P., & Soliman, K. F. A. (2020) · Antioxidants · doi:10.3390/antiox9080659 · Cited by 123 · see citing works

Redox regulation of proteasome function

Lefaki, M., Papaevgeniou, N., & Chondrogianni, N. (2017) · Redox Biology · doi:10.1016/j.redox.2017.07.005 · Cited by 114 · see citing works

Keap1‐Nrf2 signaling pathway in angiogenesis and vascular diseases

Guo, Z., & Mo, Z. (2020) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3053 · Cited by 114 · see citing works

The KEAP1-NRF2 System and Neurodegenerative Diseases

Uruno, A., & Yamamoto, M. P. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0234 · Cited by 111 · see citing works

Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function

Erkens, R., Kramer, C. M., Lückstädt, W., Panknin, C., Krause, L., Weidenbach, M., Dirzka, J., Krenz, T., Mergia, E., Suvorava, T., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.10.409 · Cited by 108 · see citing works

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres, T., Marín‐Royo, G., Opazo-Ríos, L., Jiménez-Castilla, L., Moreno, J. A., Gómez‐Guerrero, C., & Egido, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020346 · Cited by 107 · see citing works

Nrf2 as a Key Player of Redox Regulation in Cardiovascular Diseases

Barančı́k, M., Gresová, L., Barteková, M., & Dovinová, I. (2016) · Physiological Research · doi:10.33549/physiolres.933403 · Cited by 106 · see citing works

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet

Slocum, S. L., Skoko, J., Wakabayashi, N., Aja, S. M., Yamamoto, M. P., Kensler, T. W., & Chartoumpekis, D. V. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.040 · Cited by 106 · see citing works

GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition

Lu, M., Wang, P., Qiao, Y., Jiang, C., Ge, Y., Flickinger, B., Malhotra, D. K., Dworkin, L. D., Liu, Z., & Gong, R. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101275 · Cited by 102 · see citing works

Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process

Süntar, I. P., Çetinkaya, S., Panieri, E., Saha, S., Buttari, B., Profumo, E., & Saso, L. (2021) · Molecules · doi:10.3390/molecules26092424 · Cited by 99 · see citing works

Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice

Liu, Y., Uruno, A., Saito, R., Matsukawa, N., Hishinuma, E., Saigusa, D., Liu, H., & Yamamoto, M. P. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102525 · Cited by 95 · see citing works

A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds

Paunkov, A., Chartoumpekis, D. V., Ziros, P. G., & Sykiotis, G. P. (2019) · Antioxidants · doi:10.3390/antiox8090353 · Cited by 93 · see citing works

Sargassum fusiforme Fucoidan Alleviates High-Fat Diet-Induced Obesity and Insulin Resistance Associated with the Improvement of Hepatic Oxidative Stress and Gut Microbiota Profile

Zhang, Y., Zuo, J., Yan, L., Yang, C., Li, Q., Wu, S., Chen, L., Thring, R. W., Yang, Y., Gao, Y., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c02555 · Cited by 94 · see citing works

Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

Zhou, Z.-Y., Ren, L.-W., Zhan, P., Yang, H.-Y., Chai, D.-D., & Yu, Z.-W. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.21 · Cited by 92 · see citing works

NRF2 and Diabetes: The Good, the Bad, and the Complex

Dodson, M. B., Shakya, A., Anandhan, A., Chen, J., Garcia, J. G. N., & Zhang, D. D. (2022) · Diabetes · doi:10.2337/db22-0623 · Cited by 92 · see citing works

High glucose induces renal tubular epithelial injury via Sirt1/NF-kappaB/microR-29/Keap1 signal pathway

Zhou, L., Xu, D., Sha, W., Shen, L., Lu, G., Yin, X., & Wang, M. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0710-y · Cited by 90 · see citing works

Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes

Ježek, P., Jabůrek, M., & Plecitá‐Hlavatá, L. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7656 · Cited by 88 · see citing works

Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways

Dou, Y., Huang, R., Li, Q., Liu, Y., Li, Y., Chen, H., Ai, G., Xie, J., Zeng, H., Chen, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111312 · Cited by 88 · see citing works

Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2

Wu, J., Jiang, Z., Zhang, H., Liang, W., Huang, W., Zhang, H., Li, Y., Wang, Z., Wang, J., Jia, Y., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.034 · Cited by 88 · see citing works

Type I interferons and endoplasmic reticulum stress in health and disease

(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.10.004 · Cited by 83 · see citing works

Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?

Silva‐Palacios, A., Königsberg, M., & Zazueta, C. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.005 · Cited by 84 · see citing works

Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against Podocytopathy

Zhou, S., Wang, P., Qiao, Y., Ge, Y., Wang, Y., Quan, S., Yao, R., Zhuang, S., Wang, L. J., Du, Y., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050565 · Cited by 82 · see citing works

Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases

Kim, M., & Jeon, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052846 · Cited by 80 · see citing works

Mitochondrial Dysfunction in Diabetic Cardiomyopathy: The Possible Therapeutic Roles of Phenolic Acids

Jubaidi, F. F., Zainalabidin, S., Mariappan, V., & Budin, S. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176043 · Cited by 78 · see citing works

Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice

Lee, H., & Lim, Y. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.016 · Cited by 78 · see citing works

Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention

Bugno, M., Daniel, M., Chepelev, N. L., & Willmore, W. G. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.08.001 · Cited by 76 · see citing works

Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress

Zhang, Y., Wang, H., Zhang, L., Yuan, Y., & Yu, D. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.09.185 · Cited by 74 · see citing works

Role and Regulation of Glutathione Metabolism in Plasmodium falciparum

Müller, S. (2015) · Molecules · doi:10.3390/molecules200610511 · Cited by 73 · see citing works

Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology

Tiberi, J., Cesarini, V., Stefanelli, R., Canterini, S., Fiorenza, M. T., & Rosa, P. L. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111802 · Cited by 73 · see citing works

Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity

Pu, D., Zhao, Y., Chen, J., Sun, Y., Lv, A., Zhu, S., Luo, C., Zhao, K., & Xiao, Q. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.017 · Cited by 71 · see citing works

Oxidative stress biomarkers in type 2 diabetes mellitus for assessment of cardiovascular disease risk

Robson, R., Kundur, A., & Singh, I. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.12.029 · Cited by 70 · see citing works

NRF2 signalling pathway: New insights and progress in the field of wound healing

Liu, Y., Yang, X., Liu, Y., Jiang, T., Ren, S., Chen, J., Xiong, H., Yuan, M., Li, W., Machens, H., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16597 · Cited by 68 · see citing works

Anti-diabetic effects of Bifidobacterium animalis 01 through improving hepatic insulin sensitivity in type 2 diabetic rat model

Zhang, J., Wang, S., Zeng, Z., Qin, Y., Shen, Q., & Li, P. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103843 · Cited by 68 · see citing works

Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment

Shen, S., Zhong, H., Zhou, X., Li, G., Zhang, C., Zhu, Y., & Yang, Y. M. (2024) · Pharmaceutical Biology · doi:10.1080/13880209.2024.2314705 · Cited by 74 · see citing works

Cytoprotective mechanism of ferulic acid against high glucose-induced oxidative stress in cardiomyocytes and hepatocytes

Song, Y., Wen, L., Sun, J., Bai, W., Jiao, R., Hu, Y., Peng, X., He, Y., & Ou, S. (2016) · Food & Nutrition Research · doi:10.3402/fnr.v60.30323 · Cited by 66 · see citing works

In vivo antioxidant and anti-inflammatory effects of soluble dietary fiber Konjac glucomannan in type-2 diabetic rats

Zhao, Y., Jayachandran, M., & Xu, B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.105 · Cited by 66 · see citing works

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway

Cunha, D. A., Cito, M., Carlsson, P., Vanderwinden, J., Molkentin, J. D., Bugliani, M., Marchetti, P., Eizirik, D. L., & Cnop, M. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.89 · Cited by 66 · see citing works

Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials

Shao, J., Jiang, J., Zou, J., Yang, M., Chen, F., Zhang, Y.-J., & Jia, L. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103630 · Cited by 65 · see citing works

Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications

Vargas-Mendoza, N., Morales‐González, Á., Morales-Martínez, M., Soriano-Ursua, M. A., Delgado‐Olivares, L., Sandoval-Gallegos, E. M., Madrigal‐Bujaidar, E., Álvarez‐González, I., Madrigal‐Santillán, E., & Morales‐González, J. A. (2020) · Biomedicines · doi:10.3390/biomedicines8050122 · Cited by 65 · see citing works

Mechanisms behind Retinal Ganglion Cell Loss in Diabetes and Therapeutic Approach

Potilinski, M. C., Lorenc, V. E., Perisset, S., & Gallo, J. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072351 · Cited by 62 · see citing works

Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats

Fan, H., Ma, X., Lin, P., Kang, Q., Zhao, Z., Wang, L., Sun, D., Cheng, J., & Li, Y. (2017) · Medical Science Monitor · doi:10.12659/msm.907530 · Cited by 61 · see citing works

Activation of GSK3β/β-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy

Mathur, A., Pandey, V. K., & Kakkar, P. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.04.550 · Cited by 60 · see citing works

Natural Coumarin Derivatives Activating Nrf2 Signaling Pathway as Lead Compounds for the Design and Synthesis of Intestinal Anti-Inflammatory Drugs

Stasi, L. C. D. (2023) · Pharmaceuticals · doi:10.3390/ph16040511 · Cited by 60 · see citing works

Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population

Wang, X., Chen, H., Liu, J., Ouyang, Y., Wang, D., Bao, W., & Liu, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160716483 · Cited by 58 · see citing works

A review on the hypoglycemic effect, mechanism and application development of natural dietary polysaccharides

Dong, Y., Wang, Z., Chen, C., Wang, P., & Fu, X. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127267 · Cited by 55 · see citing works

Nrf2 protects against diabetic dysfunction of endothelial progenitor cells via regulating cell senescence

Wang, R., Liu, L., Liu, H., Wu, K., An, J., Wang, Q., Liu, Y., Bai, L., Qi, B., Qi, B., et al. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3727 · Cited by 55 · see citing works

Cr (VI) induces abnormalities in glucose and lipid metabolism through ROS/Nrf2 signaling

Li, X., He, S., Zhou, J., Yu, X., Li, L., Liu, Y., & Li, W. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112320 · Cited by 54 · see citing works

Oxidative stress-induced miR-27a targets the redox gene nuclear factor erythroid 2-related factor 2 in diabetic embryopathy

Zhao, Y., Dong, D., Reece, E. A., Wang, A. R., & Yang, P. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.10.040 · Cited by 50 · see citing works

Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice

Yagishita, Y., Uruno, A., Chartoumpekis, D. V., Kensler, T. W., & Yamamoto, M. P. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0355 · Cited by 50 · see citing works

Atorvastatin Regulates MALAT1/miR-200c/NRF2 Activity to Protect Against Podocyte Pyroptosis Induced by High Glucose

Zuo, Y., Chen, L., He, X., Ye, Z., Li, L., Liu, Z., & Zhou, S. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s298950 · Cited by 50 · see citing works

miRNA-155 silencing reduces sciatic nerve injury in diabetic peripheral neuropathy

Ji, C., Li, C., Liu, W., Yan, B., Hu, X., & Yang, F. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0067 · Cited by 48 · see citing works

Association of Nuclear Factor‐Erythroid 2‐Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase‐1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients

Jiménez‐Osorio, A. S., González-Reyes, S., García‐Niño, W. R., Moreno-Macías, H., Rodríguez-Arellano, M. E., Vargas‐Alarcón, G., Zúñiga, J., Barquera, R., & Pedraza‐Chaverrí, J. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7367641 · Cited by 47 · see citing works

Polysaccharides in Medicinal and Food Homologous Plants regulate intestinal flora to improve type 2 diabetes: Systematic review

Liu, W., Zhang, Y., Zheng, M., Ye, Y., Shi, M., Wang, X., Cao, L., & Wang, L. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156027 · Cited by 50 · see citing works

The Keap1–Nrf2 protein–protein interaction: A suitable target for small molecules

Schmoll, D., Engel, C. K., & Glombik, H. (2017) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2017.10.001 · Cited by 43 · see citing works

Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2‐Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action

Li, G.-H., Li, Y., Jiao, P., Zhao, Y., Hu, H., Lou, H., & Shen, T. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7309073 · Cited by 42 · see citing works

Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms

Li, X., Zhang, Q., Hou, N., Li, J., Liu, M., Peng, S., Zhang, Y., Luo, Y., Zhao, B., Wang, S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040880 · Cited by 42 · see citing works

The Therapeutic Potential of Kaemferol and Other Naturally Occurring Polyphenols Might Be Modulated by Nrf2-ARE Signaling Pathway: Current Status and Future Direction

Hussain, Y., Khan, H. Z., Alsharif, K. F., Khan, A. H., Aschner, M., & Saso, L. (2022) · Molecules · doi:10.3390/molecules27134145 · Cited by 41 · see citing works

The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice

Higashi, C., Kawaji, A., Tsuda, N., Hayashi, M., Saito, R., Yagishita, Y., Suzuki, T., Uruno, A., Nakamura, M., Nakao, K., et al. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.02.044 · Cited by 41 · see citing works

Polygonatum sibiricum polysaccharide alleviates inflammatory cytokines and promotes glucose uptake in high‑glucose‑ and high‑insulin‑induced 3T3‑L1 adipocytes by promoting Nrf2 expression

Cai, J., Zhu, Y., Zuo, Y., Tong, Q., Zhang, Z., Yang, L., Li, X., & Yi, G.-Q. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10626 · Cited by 41 · see citing works

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

Katsu-Jiménez, Y., Vazquez‐Calvo, C., Maffezzini, C., Halldin, M., Peng, X., Freyer, C., Wredenberg, A., Giménez-Cassina, A., Wedell, A., & Arnér, E. S. J. (2019) · Diabetes · doi:10.2337/db18-0557 · Cited by 37 · see citing works

Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance

Popineau, L., Morzyglod, L., Carré, N., Caüzac, M., Bossard, P., Prip‐Buus, C., Lenoir, V., Ragazzon, B., Fauveau, V., Robert, L., et al. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00170-16 · Cited by 37 · see citing works

Alterations in System xc− Expression in the Retina of Type 1 Diabetic Rats and the Role of Nrf2

Carpi-Santos, R., & Calaza, K. D. C. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0961-8 · Cited by 37 · see citing works

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation

Kumar, A. T., Katz, L. S., Schulz, A. M., Kim, M.-S., Honig, L. B., Li, L. Q., Davenport, B., Homann, D., Garcı́a-Ocaña, A., Herman, M. A., et al. (2018) · Diabetes · doi:10.2337/db17-0943 · Cited by 37 · see citing works

DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells

Zhang, X., Zhang, Y., Zhou, M., Xie, Y., Dong, X., Bai, F., & Zhang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.792977 · Cited by 37 · see citing works

Genetic variants of nuclear factor erythroid‐derived 2‐like 2 associated with the complications in Han descents with type 2 diabetes mellitus of Northeast China

Xu, X., Sun, J., Chang, X., Wang, J., Luo, M., Wintergerst, K. A., Miao, L., & Cai, L. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12900 · Cited by 36 · see citing works

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

Ibrahim, L. H., Stanton, C. R., Nutsch, K., Nguyen, T. T. A., Li-Ma, C., Ko, Y., Lander, G. C., Wiseman, R. L., & Bollong, M. J. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.07.014 · Cited by 36 · see citing works

Fermented noni ( Morinda citrifolia L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells

Zhang, X., Zhang, B., Li, L., Li, X., Zhang, J., & Chen, G. (2022) · Food & Function · doi:10.1039/d2fo00595f · Cited by 35 · see citing works

Association between consumption of fermented vegetables and COVID-19 mortality at a country level in EuropePreprint

Fonseca, S. C., Rivas, I., Romaguera, D., Quijal-Zamorano, M., Czarlewski, W., Vidal, A., Fonseca, J., Ballester, J., Antó, J. M., Basagaña, X., et al. (2020) · medRxiv · doi:10.1101/2020.07.06.20147025 · Cited by 35 · see citing works

Effects of PP2A/Nrf2 on experimental diabetes mellitus-related cardiomyopathy by regulation of autophagy and apoptosis through ROS dependent pathway

Guan, Y., Zhou, L., Zhang, Y., Tian, H., Li, A., & Han, X. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.06.004 · Cited by 34 · see citing works

Introduction to Special Issue on ‘Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine

Mann, G. E., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.002 · Cited by 34 · see citing works

New insights into anti-diabetes effects and molecular mechanisms of dietary saponins

Zhou, Y., & Xu, B. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2101425 · Cited by 33 · see citing works

Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells

Zhu, Y., Ren, C., Zhang, M., & Zhong, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00166 · Cited by 33 · see citing works

Chlordane exposure causes developmental delay and metabolic disorders in Drosophila melanogaster

Wu, Q., Du, X., Feng, X., Cheng, H., Chen, Y., Lu, C., Wu, M., & Tong, H. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112739 · Cited by 33 · see citing works

Oxidative stress parameters and keap 1 variants in T2DM: Association with T2DM, diabetic neuropathy, diabetic retinopathy, and obesity

Khalili, F., Vaisi‐Raygani, A., Shakiba, E., Kohsari, M., Dehbani, M., Naseri, R., Asadi, S., Rahimi, Z., Rahimi, Z., & Rahimi, Z. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24163 · Cited by 33 · see citing works

Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus

Liu, Y., Wang, D., & Yang, L. (2022) · Current Drug Targets · doi:10.2174/1389450123666220429082702 · Cited by 35 · see citing works

The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice

McDonnell, C., Leánez, S., & Pol, O. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180998 · Cited by 32 · see citing works

Real-ambient exposure to air pollution exaggerates excessive growth of adipose tissue modulated by Nrf2 signal.

Jiang, M.-H., Li, D.-C., Piao, J.-M., Li, J.-Y., Sun, H., Chen, L.-P., Chen, S., Pi, J., Zhang, R., Chen, R., et al. (2020) · Science of the Total Environment · doi:10.1016/j.scitotenv.2020.138652 · Cited by 30 · see citing works

DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway

Wang, K., Liang, Y., Su, Y., & Wang, L. (2020) · Biochemical Journal · doi:10.1042/bcj20200402 · Cited by 31 · see citing works

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

Uruno, A., Furusawa, Y., Yagishita, Y., Fukutomi, T., Muramatsu, H., Negishi, T., Sugawara, A., Kensler, T. W., & Yamamoto, M. P. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00225-13 · Cited by 330 · see citing works

The Keap1–Nrf2 system as an in vivo sensor for electrophiles

Uruno, A., & Motohashi, H. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.02.007 · Cited by 187 · see citing works

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Baird, L., & Yamamoto, M. P. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00099-20 · Cited by 1,600 · see citing works

Unfolding Nrf2 in diabetes mellitus

Behl, T., Kaur, I., Sehgal, A., Sharma, E., Kumar, A., Grover, M., & BUNGAU, S. G. (2021) · Molecular Biology Reports · doi:10.1007/s11033-020-06081-3 · Cited by 41 · see citing works

Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

Kobayashi, A., Kang, M.-I., Watai, Y., Tong, K. I., Shibata, T., Uchida, K., & Yamamoto, M. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.221-229.2006 · Cited by 933 · see citing works