The Green Tea Polyphenol Epigallocatechin-3-Gallate Attenuates Age-Associated Muscle Loss via Regulation of MiR-486-5p and Myostatin
Abstract
(-)-Epigallocatechin-3-gallate (EGCG), the most abundant catechin component in green tea, has been reported to attenuate age-associated insulin resistance, lipogenesis and loss of muscle mass through restoring Akt activity in skeletal muscle in our previous and present studies. Accumulated data has suggested that polyphenols regulate signaling pathways involved in aging process such as inflammation and oxidative stress via modulation of miRNA expression. Here we found that miRNA-486-5p was significantly decreased in both aged senescence accelerated mouse-prone 8 (SAMP8) mice and late passage C2C12 cells. Thus, we further investigated the regulatory effect of EGCG on miRNA-486-5p expression in age-regulated muscle loss. SAMP8 mice were fed with chow diet containing without or with 0.32% EGCG from aged 32 weeks for 8 weeks. Early passage (<12 passages) and late passage (>30 passages) of C2C12 cells were treated without or with EGCG at concentrations of 50 μM for 24h. Our data showed that EGCG supplementation increased miRNA-486-5p expression in both aged SAMP8 mice and late passage C2C12 cells. EGCG stimulated AKT phosphorylation and inhibited FoxO1a-mediated MuRF1 and Atrogin-1 transcription via up-regulating the expression of miR-486 in skeletal muscle of 40-wk-old SAMP8 mice as well as late passage C2C12 cells. In addition, myostatin expression was increased in late passage C2C12 cells and anti-myostatin treatment upregulated the expression of miR-486-5p. Our results identify a unique mechanism of a dietary constituent of green tea and suggest that use of EGCG or compounds derived from it attenuates age-associated muscle loss via myostatin/miRNAs/ubiquitin-proteasome signaling.
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EGCG supplementation reduces age-related sarcopenia in mice.
“Interestingly, EGCG anti-senescence effects can also be observed at a macroscopic level as its supplementation reduces age-related sarcopenia in mice [293].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [293]
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- Authors
- Chang, Y.-C., Liu, H.-W., Chan, Y.-C., Hu, S.-H., Liu, M.-Y., & Chang, S.-J.
- Affiliations
- National Cheng Kung University (TW)
- National Taiwan Normal University (TW)
- Providence University (TW)
- Kaohsiung Medical University (TW)
- WuFeng University (TW)
- Corresponding author
- Chang, Sue-Joan
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 692
- Pages
- 108511
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W3044736339
- Cited by
- 57
- References
- 37
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 15 · 2023: 10 · 2022: 8 · 2021: 6 · 2020: 2
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology, Taiwan (104-2320-B-006-023-MY3, 107-2320-B-006-021-MY3, 107-2811-B-006-006, 107-2811-B-006-013)
- Ministerio de Ciencia y Tecnología
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- epigallocatechin gallate, green tea polyphenols, sarcopenia, miR-486-5p, myostatin, skeletal muscle atrophy, MuRF1, atrogin-1, FOXO1, Akt phosphorylation, SAMP8 mice, C2C12 myoblasts, dietary polyphenols
- MeSH terms
- Aging, Animals, Catechin, Cell Line, Gene Expression Regulation, Mice, Transgenic, Muscle Proteins, Muscular Atrophy, Tea, MicroRNAs, Mice, Myostatin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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