Safety of local anesthetics
Open accessAbstract
Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types. Systemic toxicity with reflex on the central nervous and cardiovascular systems is their most feared adverse reactions, and the anaphylactic reaction is the most concerning one. Although potentially fatal, these events are extremely rare, so local anesthetics are considered safe for use in in-office procedures.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The performance of the procedures with local anesthesia and vasoconstrictors (100 cases) in the outpatient setting (95 cases) did not show an increase in risks or complications for the patients.
“The performance of the procedures with local anesthesia and vasoconstrictors (100 cases) in the outpatient setting (95 cases) did not show an increase in risks or complications for the patients, data that have been well established in the literature.17, 18, 19, 20, 21”
From Auricular reconstruction after Mohs micrographic surgery: analysis of 101 cases (2021) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tumescent Technique for Regional Anesthesia Permits Lidocaine Doses of 35 mg/kg for Liposuction
Klein, J. A. (1990) · The Journal of Dermatologic Surgery and Oncology · doi:10.1111/j.1524-4725.1990.tb03961.x · Cited by 675 · see citing works
Maximum recommended doses of local anesthetics: A multifactorial concept
Rosenberg, P. H., Veering, B. T., & Urmey, W. F. (2004) · Regional Anesthesia & Pain Medicine · doi:10.1016/j.rapm.2004.08.003 · Cited by 516 · see citing works
Barrington, M. J., & Kluger, R. (2013) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e318292669b · Cited by 410 · see citing works
Neal, J. M., Mulroy, M. F., & Weinberg, G. L. (2012) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e31822e0d8a · Cited by 334 · see citing works
Safety of Tumescent Liposuction in 15,336 Patients
HANKE, W. C., BERNSTEIN, G., & BULLOCK, S. (1995) · Dermatologic Surgery · doi:10.1111/j.1524-4725.1995.tb00213.x · Cited by 269 · see citing works
Sites, B. D., Taenzer, A. H., Herrick, M. D., et al. (2012) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e31825cb3d6 · Cited by 267 · see citing works
Safety of dermatologic medications in pregnancy and lactation
Murase, J. E., Heller, M. M., & Butler, D. C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.09.010 · Cited by 220 · see citing works
Benefit and Risks of Local Anesthetics in Infants and Children
Gunter, J. B. (2002) · Pediatric Drugs · doi:10.2165/00128072-200204100-00003 · Cited by 199 · see citing works
Estimated Maximal Safe Dosages of Tumescent Lidocaine
Klein, J. A., & Jeske, D. R. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001119 · Cited by 166 · see citing works
Guidelines for the use of local anesthesia in office-based dermatologic surgery
Kouba, D. J., LoPiccolo, M. C., Alam, M., Bordeaux, J. S., COHEN, B. A., Hanke, C. W., Jellinek, N. J., Maibach, H. I., Tanner, J. W., Vashi, N. A., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.01.022 · Cited by 158 · see citing works
Contact dermatitis: Allergic and irritant
Tan, C.-H., Rasool, S., & Johnston, G. A. (2013) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2013.05.033 · Cited by 155 · see citing works
A prospective study of the incidence of complications associated with dermatological surgery
Amici, J. M., Rogues, A. M., Lashéras, A., et al. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06861.x · Cited by 146 · see citing works
Office-based ambulatory anesthesia: outcomes of clinical practice of oral and maxillofacial surgeons
Perrott, D. H., Yuen, J. P., Andresen, R. V., et al. (2003) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0278-2391(03)00668-2 · Cited by 146 · see citing works
IgE-mediated allergy to local anaesthetics: separating fact from perception: a UK perspective
Bhole, M. V., Manson, A. L., Seneviratne, S. L., et al. (2012) · British Journal of Anaesthesia · doi:10.1093/bja/aes162 · Cited by 143 · see citing works
Toxicity of local anesthetics in infants and children
Berde, C. B. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(11)80004-1 · Cited by 142 · see citing works
Topical Anesthetics for Dermatologic Procedures: A Review
Sobanko, J. F., Miller, C. J., & Alster, T. S. (2012) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2011.02271.x · Cited by 138 · see citing works
Lirk, P. B., Picardi, S., & Hollmann, M. W. (2014) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000137 · Cited by 137 · see citing works
Topical anesthetics in dermatology
Huang, W., & Vidimos, A. T. (2000) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2000.106506 · Cited by 123 · see citing works
Vasques, F., Behr, A. U., Weinberg, G. L., et al. (2015) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000320 · Cited by 106 · see citing works
Safety of dermatologic medications in pregnancy and lactation
Butler, D. C., Heller, M. M., & Murase, J. E. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.09.009 · Cited by 105 · see citing works
Maximum Recommended Doses of Local Anesthetics: A Multifactorial Concept
&NA; (2005) · Obstetric Anesthesia Digest · doi:10.1097/00132582-200509000-00007 · Cited by 94 · see citing works
Starling, J., THOSANI, M. K., & Coldiron, B. M. (2011) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2011.02206.x · Cited by 93 · see citing works
Risk of systemic toxicity with topical lidocaine/prilocaine: a review.
Tran, A. N., & Koo, J. Y. M. (2014) · PubMed · Cited by 91 · see citing works
Principles of office anesthesia: part II. Topical anesthesia.
Kundu, S., & Achar, S. A. (2002) · PubMed · Cited by 76 · see citing works
Efficacy of erbium:yttrium-aluminum-garnet laser-assisted delivery of topical anesthetic
Yun, P. L., Tachihara, R., & Anderson, R. R. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.124819 · Cited by 65 · see citing works
Application of Local Anesthetics in Dermatologic Surgery
Koay, J. L., & Orengo, I. F. (2002) · Dermatologic Surgery · doi:10.1046/j.1524-4725.2002.01126.x · Cited by 60 · see citing works
Wentworth, A. B., Yiannias, J. A., Keeling, J. H., et al. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.09.047 · Cited by 58 · see citing works
Lidocaine Contact Allergy Is Becoming More Prevalent
To, D., Kossintseva, I., & de Gannes, G. (2014) · Dermatologic Surgery · doi:10.1097/dss.0000000000000190 · Cited by 57 · see citing works
A Review of Local Anesthetics: Minimizing Risk and Side Effects in Cutaneous Surgery
Park, K. K., & Sharon, V. R. (2016) · Dermatologic Surgery · doi:10.1097/dss.0000000000000887 · Cited by 52 · see citing works
Koeppe, T., Constantinescu, M. A., Schneider, J., et al. (2005) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000161671.34502.40 · Cited by 50 · see citing works
Kvisselgaard, A. D., Mosbech, H., Fransson, S., et al. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.08.010 · Cited by 50 · see citing works
Skidmore, R. A., PATTERSON, J. D., & Tomsick, R. S. (1996) · Dermatologic Surgery · doi:10.1111/j.1524-4725.1996.tb00366.x · Cited by 46 · see citing works
Local anesthesia for dermatologic surgery.
Auletta, M. J. (1994) · PubMed · Cited by 42 · see citing works
Injection pain of bupivacaine with epinephrine vs. prilocaine plain
Wahl, M. J., SCHMITT, M. M., Overton, D. A., et al. (2002) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2002.0115 · Cited by 40 · see citing works
Alam, M., Ricci, D., Havey, J., et al. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.08.046 · Cited by 34 · see citing works
Serrera‐Figallo, M., Velázquez-Cayón, R. T., Lagares, D., et al. (2012) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.50590 · Cited by 29 · see citing works
Application of Local Anesthetics in Dermatologic Surgery
Koay, J. L., & Orengo, I. F. (2002) · Dermatologic Surgery · doi:10.1097/00042728-200202000-00009 · Cited by 27 · see citing works
Age does not influence the serum protein binding of bupivacaine.
Veering, B. T., Burm, A., Gladines, M. P. R. R., et al. (1991) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1991.tb03938.x · Cited by 25 · see citing works
Häfner, H., Schmid, U., Moehrle, M., et al. (2008) · PubMed · Cited by 24 · see citing works
Larson, M. J., & Taylor, R. S. (2004) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2004.30216.x · Cited by 24 · see citing works
Alam, M., Schaeffer, M. R., Geisler, A., Poon, E., Fosko, S. W., & Srivastava, D. (2016) · Dermatologic Surgery · doi:10.1097/dss.0000000000000907 · Cited by 23 · see citing works
Identifying and Managing Local Anesthetic Allergy in Dermatologic Surgery
Fathi, R., Serota, M., & Brown, M. R. (2016) · Dermatologic Surgery · doi:10.1097/dss.0000000000000596 · Cited by 19 · see citing works
Knowledge of Local Anesthetic Use Among Dermatologists
Walsh, A. M., Moran, B., & Walsh, S. (2012) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2012.02409.x · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Auricular reconstruction after Mohs micrographic surgery: analysis of 101 cases
Bittner, G. C., Kubo, E. M., Fantini, B. D. C., & Cerci, F. B. (2021) · Anais Brasileiros de Dermatologia · doi:10.1016/j.abd.2020.12.008 · Cited by 14 · see citing works
- Authors
- Cherobin, A. C. F. P., & Tavares, G. T.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Cherobin, Ana Carolina Figueiredo Pereira
- Venue
- Anais Brasileiros de Dermatologia
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 95
- Issue
- 1
- Pages
- 82-90
- ISSN
- 0365-0596 (ISSN-L)
- PMC
- PMC7058875
- OpenAlex
- W2996089471
- Cited by
- 106
- References
- 43
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 20 · 2023: 25 · 2022: 15 · 2021: 20 · 2020: 3 · 2013: 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Anais Brasileiros de Dermatologia (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Dentistry › Oral Surgery › Dental Anxiety and Anesthesia Techniques
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- local anesthetics, local anesthetic safety, amide local anesthetics, ester local anesthetics, systemic toxicity, central nervous system toxicity, cardiotoxicity, anaphylaxis, adverse drug reactions
- MeSH terms
- Anesthetics, Local, Bupivacaine, Drug Hypersensitivity, Epinephrine, Humans, Lidocaine, Mepivacaine, Risk Factors, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
