Recent advances in analytical methods for the determination of 4-alkylphenols and bisphenol A in solid environmental matrices: A critical review
Abstract
The problem of endocrine disrupting compounds (EDCs) in the environment has become a worldwide concern in recent decades. Besides their toxicological effects at low concentrations and their widespread use in industrial and household applications, these pollutants pose a risk for non-target organisms and also for public safety. Analytical methods to determine these compounds at trace levels in different matrices are urgently needed. This review critically discusses trends in analytical methods for well-known EDCs like alkylphenols and bisphenol A in solid environmental matrices, including sediment and aquatic biological samples (from 2006 to 2018). Information about extraction, clean-up and determination is covered in detail, including analytical quality parameters (QA/QC). Conventional and novel analytical techniques are compared, with their advantages and drawbacks. Ultrasound assisted extraction followed by solid phase extraction clean-up is the most widely used procedure for sediment and aquatic biological samples, although softer extraction conditions have been employed for the latter. The use of liquid chromatography followed by tandem mass spectrometry has greatly increased in the last five years. The majority of these methods have been employed for the analysis of river sediments and bivalve molluscs because of their usefulness in aquatic ecosystem (bio)monitoring programs. Green, simple, fast analytical methods are now needed to determine these compounds in complex matrices.
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BPA as a carcinogen can be found in food products stored in plastic packaging.
“It is known, that BPA as a carcinogen can be found in food products stored in the plastic packaging.17”
From Deep eutectic solvents as a new kind of dispersive solvent for dispersive liquid–liquid microextraction (2018) · cites this paper as [17]
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- Authors
- Salgueiro-González, N., Castiglioni, S., Zuccato, E., Turnes-Carou, I., López-Mahía, P., & Muniategui-Lorenzo, S.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- Universidade da Coruña (ES)
- Corresponding author
- Castiglioni, S.
- Venue
- Analytica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 1024
- Pages
- 39-51
- ISSN
- 0003-2670 (ISSN-L)
- OpenAlex
- W2791873608
- Cited by
- 54
- References
- 69
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 13 · 2019: 6 · 2018: 5
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Xunta de Galicia and cofinanced by ERDF (ED431C 2017/28)
- Spanish Ministry of Economy and Competitiveness, cofinanced by ERDF (CTM2013-48194-C3-2-R, CTM2016-77945-C3-3-R)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Keywords
- 4-alkylphenols, bisphenol A, endocrine disruptors, sediment analysis, Bivalvia, ultrasound-assisted extraction, solid-phase extraction, sample cleanup, liquid chromatography-tandem mass spectrometry, biomonitoring, green analytical method, trace analysis
- MeSH terms
- Ultrasonic Waves, Bisphenol A Compounds, Animals, Benzhydryl Compounds, Chemistry Techniques, Analytical, Humans, Phenols, Soil Pollutants, Water Pollutants, Chemical, Geologic Sediments, Bivalvia, Endocrine Disruptors, Solid Phase Extraction
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