Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate
Open accessAbstract
Metallic zinc implanted into the abdominal aorta of rats out to 6months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions. We found that zinc wires implanted in the murine artery exhibit steady corrosion without local toxicity for up to at least 20months post-implantation, despite a steady buildup of passivating corrosion products and intense fibrous encapsulation of the wire. Although fibrous encapsulation was not able to prevent continued implant corrosion, it may be related to the reduced chronic inflammation observed between 10 and 20months post-implantation. X-ray elemental and infrared spectroscopy analyses confirmed zinc oxide, zinc carbonate, and zinc phosphate as the main components of corrosion products surrounding the Zn implant. These products coincide with stable phases concluded from Pourbaix diagrams of a physiological solution and in vitro electrochemical impedance tests. The results support earlier predictions that zinc stents could become successfully bio-integrated into the arterial environment and safely degrade within a time frame of approximately 1-2years.Staement of significance Previous studies have shown zinc to be a promising candidate material for bioresorbable endovascular stenting applications. An outstanding question, however, is whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated tissue encapsulation process that prevented the diffusion of critical reactants and products at the metal surface. We found that zinc wires implanted in the murine artery exhibit steady corrosion for up to at least 20months post-implantation. The results confirm earlier predictions that zinc stents could safely degrade within a time frame of approximately 1-2years.
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The present findings, with emerging use of zinc in biocompatible implants, provide a positive indication of the potential biocompatibility of a ZnIUD.
“Although there have been significantly fewer studies conducted on the interaction of zinc in the uterus compared to those of copper, the present findings, in conjunction with the emerging use of zinc in biocompatible implants provides a positive indication of the potential biocompatibility of a ZnIUD (29,30).”
From Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD) (2022) · cites this paper as [29]
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- Authors
- Drelich, A. J., Zhao, S., Guillory, R. J., Drelich, J. W., & Goldman, J.
- Affiliations
- Michigan Technological University (US)
- Corresponding author
- Goldman, Jeremy
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 58
- Pages
- 539-549
- ISSN
- 1742-7061 (ISSN-L)
- PMC
- PMC5553077
- OpenAlex
- W2614522135
- Cited by
- 188
- References
- 59
- Citations by year
- 2026: 14 · 2025: 32 · 2024: 14 · 2023: 20 · 2022: 22 · 2021: 16 · 2020: 25 · 2019: 25 · 2018: 17 · 2017: 3
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons - Michigan Tech (Michigan Technological University) (submittedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (1R15 HL129199-01)
- National Institute of Biomedical Imaging and Bioengineering (5R21EB 019118-02)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- microbiologically influenced corrosion, biodegradable stents, vascular implants, corrosion products, zinc oxide, zinc carbonate, zinc phosphate, fibrous encapsulation, chronic inflammation, passivation, abdominal aorta, endovascular stenting
- MeSH terms
- Animals, Aorta, Blood Vessel Prosthesis, Materials Testing, Zinc, Mice
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