The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Customizing poly(lactic-co-glycolic acid) particles for biomedical applications
Open accessAbstract
Nano- and microparticles have increasingly widespread applications in nanomedicine, ranging from drug delivery to imaging. Poly(lactic-co-glycolic acid) (PLGA) particles are the most widely-applied type of particles due to their biocompatibility and biodegradability. Here, we discuss the preparation of PLGA particles, and various modifications to tailor particles for applications in biological systems. We highlight new preparation approaches, including microfluidics and PRINT method, and modifications of PLGA particles resulting in novel or responsive properties, such as Janus or upconversion particles. Finally, we describe how the preparation methods can- and should-be adapted to tailor the properties of particles for the desired biomedical application. Our aim is to enable researchers who work with PLGA particles to better appreciate the effects of the selected preparation procedure on the final properties of the particles and its biological implications. STATEMENT OF SIGNIFICANCE: Nanoparticles are increasingly important in the field of biomedicine. Particles made of polymers are in the spotlight, due to their biodegradability, biocompatibility, versatility. In this review, we aim to discuss the range of formulation techniques, manipulations, and applications of poly(lactic-co-glycolic acid) (PLGA) particles, to enable a researcher to effectively select or design the optimal particles for their application. We describe the various techniques of PLGA particle synthesis and their impact on possible applications. We focus on recent developments in the field of PLGA particles, and new synthesis techniques that have emerged over the past years. Overall, we show how the chemistry of PLGA particles can be adapted to solve pressing biological needs.
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2 retracted
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RetractedRETRACTED: Insulin-loaded PLGA microspheres for glucose-responsive release
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Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
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“There are three primary mechanisms by which active agents can be released from a delivery system: diffusion, degradation, and swelling followed by diffusion [15].”
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Cited by
Del Amo, L., Cano, A., Ettcheto, M., Souto, E. B., Espina, M., Camins, A., García, M. L., & Sánchez-López, E. (2021) · Applied Sciences · doi:10.3390/app11094305 · Cited by 67
Nanomaterials: Breaking through the bottleneck of tumor immunotherapy
Kang, Y., & Li, S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123159 · Cited by 61
Metadata
- Authors
- Swider, E., Koshkina, O., Tel, J., Cruz, L. J., de Vries, I. J. M., & Srinivas, M.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 73
- Pages
- 38-51
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2797789122
- Cited by
- 328
- References
- 116
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Swider, E., Koshkina, O., Tel, J., Cruz, L. J., de Vries, I. J. M., & Srinivas, M. (2018). Customizing poly(lactic-co-glycolic acid) particles for biomedical applications. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2018.04.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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