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Cited by 15Child Abuse and TraumaSubstance Abuse Treatment and OutcomesMental Health Treatment and Access

Depression and its association with adverse childhood experiences in people with substance use disorders and comorbid medical illness recruited during medical hospitalization

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Philogene-Khalid, Helene L., Cunningham, Eric, Yu, Daohai, Chambers, Jaclyn E., Brooks, Adam, Lu, Xiaoning, Morrison, Mary F.·2020·Addictive Behaviors
DOI 10.1016/j.addbeh.2020.106489PMC PMC7899289
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Abstract

Aims People who have experienced adverse childhood experiences (ACEs) are more susceptible to substance use disorder (SUD) and depression. The present study examined depression prevalence in hospitalized patients with SUD and examined the association of individual ACEs with major depression. Depression rates 3 months after discharge were also examined.Methods Medical inpatients with SUD were recruited from Temple University Hospital. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9) at baseline and 3 months post-discharge. Participants were also assessed using an ACE scale at baseline.Results Of 79 baseline participants, 48% (38) had moderate to severe major depressive disorder (MDD) with PHQ-9 scores ≥15. Among those with baseline MDD, 38% (9/24) continued to have MDD 3 months post discharge, and 42.9% (12/28) of those without MDD at baseline met criteria at 3 months. Sixty-three percent (50/79) of the participants reported 4+ ACEs at baseline. Two ACEs, Household Incarceration and Household Mental Illness, were significantly associated with having MDD at baseline and 3 months (adjusted mean PHQ-9 total score increase (SE) and p-value: 2.97 (1.35), p < .05; 5.32 (1.37), p < .005, respectively).Conclusions In this exploratory study, nearly half of medical inpatients with substance use disorder had moderate to severe major depression, with a similar percentage of participants having MDD as outpatients at 3 months. Approximately two thirds of participants reported four or more adverse childhood experiences at baseline. Inpatient medical hospitalization should be utilized as an opportunity to engage people with SUD in multidisciplinary treatment including psychiatric, trauma informed care, and substance abuse treatment.

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  • People in treatment for an addiction have a higher prevalence of ACEs than the general population.

    “In fact, people in treatment for an addiction have a higher prevalence of ACEs than the general population.”

    From Adverse childhood experiences (ACEs) and substance use disorder (SUD): A scoping review (2021) · cites this paper as Philogene-Khalid et al., 2020

    The Discussion says people with substance use disorders experience ACEs at a disproportionate frequency, and the Results report that 91% of this study’s participants had at least one ACE. But the Methods describe participants recruited during medical hospitalization, not people in addiction treatment, and the paper does not directly compare their ACE prevalence with that of the general population. No page numbers were available in our copy. (LLM, conf=0.87)

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  • Among patients with addiction problems, the rates of having suffered at least one ACE range from 85.4% to 100%.

    “Among patients with addiction problems, the rates of having suffered at least one ACE ranges from 85.4% to 100% (Chandler et al., 2018;Philogene-Khalid et al., 2020;Stein et al., 2017).”

    From Adverse childhood experiences (ACEs) and substance use disorder (SUD): A scoping review (2021) · cites this paper as Philogene-Khalid et al., 2020

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Authors
Philogene-Khalid, H. L., Cunningham, E., Yu, D., Chambers, J. E., Brooks, A., Lu, X., & Morrison, M. F.
Affiliations
  • Temple University (US)
  • University of California, Berkeley (US)
  • Public Health Management Corporation (US)
Corresponding author
Philogene-Khalid, Helene L.
ORCID
Venue
Addictive Behaviors
Publisher
Elsevier BV
Published
2020-11
Volume
110
Pages
106489
ISSN
0306-4603 (ISSN-L)
DOI
10.1016/j.addbeh.2020.106489
PMC
PMC7899289
OpenAlex
W3033386304
Cited by
15
References
28
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 2
FWCI
0.80
Type
journal article
Language
en
Open access
Licence
Locations
  • Addictive Behaviors (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Patient-Centered Outcomes Research Institute
  • Temple University
  • National Institute on Drug Abuse (T32 DA007237)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
depression, major depressive disorder, adverse childhood experiences, substance use disorders, comorbidities, hospitalized patients, household mental illness, depression prevalence, trauma-informed care, multidisciplinary treatment
MeSH terms
Adverse Childhood Experiences, Aftercare, Child, Depression, Depressive Disorder, Major, Major Depressive Disorder, Hospitalization, Humans, Patient Discharge, Substance-Related Disorders

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