Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,746

The DOI matches its Crossref record.

Penetration enhancers

Williams, Adrian C, Barry, Brian W·2004·Advanced Drug Delivery Reviews
DOI 10.1016/j.addr.2003.10.025
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.addr.2003.10.025

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 59

  1. Walkley, 1972, Bound water in stratum corneum measured by differential scanning calorimetry, J. Invest. Dermatol., 59, 225, 10.1111/1523-1747.ep12627251 · doi:10.1111/1523-1747.ep12627251
  2. Cornwell, 1994, Sesquiterpene components of volatile oils as skin penetration enhancers for the hydrophilic permeant 5-fluorouracil, J. Pharm. Pharmacol., 46, 261, 10.1111/j.2042-7158.1994.tb03791.x · DOI
  3. Van Hal, 1996, Structure of fully hydrated human stratum corneum: a freeze fracture electron microscopy study, J. Invest. Dermatol., 106, 89, 10.1111/1523-1747.ep12328031 · DOI
  4. Elias, 2002, The potential of metabolic interventions to enhance transdermal drug delivery, JID Symp. Proc., 7, 79
  5. Bond, 1986, Limitations of hairless mouse skin as a model for in vitro permeation studies through human skin: hydration damage, J. Invest. Dermatol., 90, 486, 10.1111/1523-1747.ep12460958 · DOI
  6. Kligman, 1965, Topical pharmacology and toxicology of dimethylsulfoxide, J. Am. Med. Assoc., 193, 796, 10.1001/jama.1965.03090100042010 · doi:10.1001/jama.1965.03090100042010
  7. Southwell, 1983, Penetration enhancers for human skin: mode of action of 2-pyrrolidone and dimethylformamide on partition and diffusion of model compounds water, n-alcohols and caffeine, J. Invest. Dermatol., 80, 507, 10.1111/1523-1747.ep12535090 · DOI
  8. Barry, 1984, Optimisation of bioavailability of topical steroids: penetration enhancers under occlusion, J. Invest. Dermatol., 82, 49, 10.1111/1523-1747.ep12259101 · DOI
  9. Bennett, 1984, Optimisation of bioavailability of topical steroids: non-occluded penetration enhancers under thermodynamic control, J. Pharm. Pharmacol., 37, 298, 10.1111/j.2042-7158.1985.tb05070.x · doi:10.1111/j.2042-7158.1985.tb05070.x
  10. Oertel, 1997, Protein conformational changes induced in human stratum corneum by organic sulphoxides: an infrared spectroscopic investigation, Biopolymer, 16, 2329, 10.1002/bip.1977.360161017 · doi:10.1002/bip.1977.360161017
  11. Anigbogu, 1995, Fourier transform Raman spectroscopy of interactions between the penetration enhancer dimethylsulphoxide and human stratum corneum, Int. J. Pharm., 125, 265, 10.1016/0378-5173(95)00141-5 · DOI · Paper page
  12. Hoogstraate, 1991, Kinetics, ultrastructural aspects and molecular modelling of transdermal peptide flux enhancement by N-alkylazacycloheptanones, Int. J. Pharm., 76, 37, 10.1016/0378-5173(91)90341-K · DOI
  13. Pilgram, 2001, The influence of two azones and sebaceous lipids on the lateral organization of lipids isolated from human stratum corneum, Biochim. Biophys. Acta—Biomembr., 1511, 244, 10.1016/S0005-2736(01)00271-1 · DOI
  14. J.W. Wiechers, Absorption, distribution, metabolism, and exretion of the cutaneous penetration enhancer Azone, Ph.D. thesis, University of Groningen, 1989.
  15. Wiechers, 1990, Transdermal drug delivery: efficacy and potential applications of the penetration enhancer Azone, Drug Des. Deliv., 6, 87
  16. M.I. Afouna, T.K. Fincher, A.A.A. Zaghloul, I.K. Reddy, Effect of Azone upon the in vivo antiviral efficacy of cidofovir or acyclovir topical formulations in treatment/prevention of cutaneous HSV-1 infections and its correlation with skin target site free drug concentration in hairless mice, Int. J. Pharm. 253 (2003) 159–168. · doi:10.1016/s0378-5173(02)00705-6
  17. Park, 2001, Effects of adhesives and permeation enhancers on the skin permeation of captopril, Drug Dev. Ind. Pharm., 27, 975, 10.1081/DDC-100107679 · doi:10.1081/ddc-100107679
  18. Jungbauer, 2001, Toxic hygroscopic contact reaction to N-methyl-2-pyrrolidone, Contact Dermatitis, 45, 303, 10.1034/j.1600-0536.2001.450514.x · DOI
  19. Aungst, 1986, Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides, Int. J. Pharm., 33, 225, 10.1016/0378-5173(86)90057-8 · DOI · Paper page
  20. Aungst, 1989, Structure-effects studies of fatty acid isomers as skin penetration enhancers and skin irritants, Pharm. Res., 6, 244, 10.1023/A:1015921702258 · DOI
  21. Funke, 2002, Transdermal delivery of highly lipophilic drugs: in vitro fluxes of antiestrogens, permeation enhancers, and solvents from liquid formulations, Pharm. Res., 19, 661, 10.1023/A:1015314314796 · doi:10.1023/a:1015314314796
  22. Santoyo, 2000, Effect of skin pre-treatment with fatty acids on percutaneous absorption and skin retention of piroxicam after its topical application, Eur. J. Pharm. Biopharm., 50, 245, 10.1016/S0939-6411(00)00097-7 · DOI
  23. Goodman, 1989, Lipid–protein-partitioning theory (LPP) theory of skin enhancer activity: finite dose technique, Int. J. Pharm., 57, 29, 10.1016/0378-5173(89)90260-3 · DOI
  24. Aboofazeli, 2002, Transdermal delivery of nicardipine: an approach to in vitro permeation enhancement, Drug Deliv., 9, 239, 10.1080/10717540260397855 · doi:10.1080/10717540260397855
  25. Takahashi, 2002, Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin, Drug Dev. Ind. Pharm., 28, 1285, 10.1081/DDC-120015362 · DOI
  26. Ongpipattanakul, 1991, Evidence that oleic acid exists in a separate phase within stratum corneum lipids, Pharm. Res., 7, 350, 10.1023/A:1015845632280 · DOI · Paper page
  27. Tanojo, 1997, In vitro human skin barrier perturbation by oleic acid: thermal analysis and freeze fracture electron microscopy studies, Thermochim. Acta, 293, 77, 10.1016/S0040-6031(97)00063-4 · DOI
  28. Berner, 1989, Ethanol: water mutually enhanced transdermal therapeutic system: II. Skin permeation of ethanol and nitroglycerin, J. Pharm. Sci., 78, 402, 10.1002/jps.2600780512 · doi:10.1002/jps.2600780512
  29. Friend, 1988, Transdermal delivery of levonorgestrel I. Alkanols as permeation enhancers, J. Control. Release, 7, 243, 10.1016/0168-3659(88)90057-0 · doi:10.1016/0168-3659(88)90057-0
  30. Pershing, 1990, Mechanism of ethanol-enhanced estradiol permeation across human skin in vivo, Pharm. Res., 7, 170, 10.1023/A:1015832903398 · doi:10.1023/a:1015832903398
  31. Kurihara-Bergstrom, 1990, Percutaneous absorption enhancement of an ionic molecule by ethanol–water systems in human skin, Pharm. Res., 7, 762, 10.1023/A:1015879925147 · doi:10.1023/a:1015879925147
  32. Megrab, 1995, Oestradiol permeation across human skin, silastic and snake skin membranes: the effects of ethanol/water co-solvent systems, Int. J. Pharm., 116, 101, 10.1016/0378-5173(94)00321-U · DOI · Paper page
  33. Thomas, 2003, Transdermal delivery of zidovudine: effect of vehicles on permeation across rat skin and their mechanism of action, Pharm. Sci., 18, 71
  34. Morimoto, 2002, In vitro skin permeation of morphine hydrochloride during the finite application of penetration-enhancing system containing water, ethanol and l-menthol, Biol. Pharm. Bull., 25, 134, 10.1248/bpb.25.134 · doi:10.1248/bpb.25.134
  35. Andega, 2001, Comparison of the effect of fatty alcohols on the permeation of melatonin between porcine and human skin, J. Control. Release, 77, 17, 10.1016/S0168-3659(01)00439-4 · DOI
  36. Tupker, 1990, The transient and cumulative effect of sodium lauryl sulphate on the epidermal barrier assessed by transepidermal water loss: inter-individual variation, Acta Derm. Venereol. (Stockh.), 70, 1, 10.2340/000155557015 · DOI
  37. Watkinson, 1998, Skin penetration of a series of nonoxynol homologues, vol. 5b, 54
  38. Sarpotdar, 1986, Percutaneous absorption enhancement by non-ionic surfactants, Drug Dev. Ind. Pharm., 12, 1625, 10.3109/03639048609042599 · doi:10.3109/03639048609042599
  39. Sarpotdar, 1986, Evaluation of penetration enhancement of lidocaine by non-ionic surfactants through hairless mouse skin in vitro, J. Pharm. Sci., 75, 176, 10.1002/jps.2600750216 · doi:10.1002/jps.2600750216
  40. Yu, 1988, Percutaneous absorption of nicardipine and ketorolac in rhesus monkeys, Pharm. Res., 5, 457, 10.1023/A:1015900804327 · doi:10.1023/a:1015900804327
  41. Rigg, 1990, Shed snake skin and hairless mouse skin as model membranes for human skin during permeation studies, J. Invest. Dermatol., 94, 235, 10.1111/1523-1747.ep12874561 · DOI
  42. Gloor, 2001, Clinical effect of salicylic acid and high dose urea applied in standardized NRF formulations, Pharmazie, 56, 810
  43. Wong, 1989, Unsaturated cyclic ureas as new non-toxic biodegradable transdermal penetration enhancers: II. Evaluation study, Int. J. Pharm., 52, 191, 10.1016/0378-5173(89)90220-2 · doi:10.1016/0378-5173(89)90220-2
  44. Williams, 1989, Urea analogues in propylene glycol as penetration enhancers in human skin, Int. J. Pharm., 56, 43, 10.1016/0378-5173(89)90059-8 · doi:10.1016/0378-5173(89)90059-8
  45. Williams, 1989, Essential oils as novel human skin penetration enhancers, Int. J. Pharm., 57, R7, 10.1016/0378-5173(89)90310-4 · doi:10.1016/0378-5173(89)90310-4
  46. Williams, 1991, Terpenes and the lipid–protein-partititioning theory of skin penetration enhancers, Pharm. Res., 8, 17, 10.1023/A:1015813803205 · DOI · Paper page
  47. Williams, 1991, The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs, Int. J. Pharm., 74, 157, 10.1016/0378-5173(91)90232-D · DOI
  48. Okabe, 1989, Effect of limonene and related compounds on the percutaneous absorption of indomethacin, Drug Des. Deliv., 4, 313
  49. B.W. Barry, A.C. Williams, Human skin penetration enhancement: the synergy of propylene glycol with terpenes, Proceedings of the 16th International Symposium on Controlled Release Bioactive Material, Chicago, USA, 1989, pp. 33–34.
  50. Fang, 2003, Efficacy and irritancy of enhancers on the in vitro and in vivo percutaneous absorption of curcumin, J. Pharm. Pharmacol., 55, 593, 10.1211/002235703765344496 · DOI
  51. Cornwell, 1994, Sesquiterpene components of volatile oils as skin penetration enhancers for the hydrophilic permeant 5-fluorouracil, J. Pharm. Pharmacol., 46, 261, 10.1111/j.2042-7158.1994.tb03791.x · DOI
  52. Kadir, 1991, α-Bisabolol, a possible safe penetration enhancer for dermal and transdermal therapeutics, Int. J. Pharm., 70, 87, 10.1016/0378-5173(91)90167-M · DOI
  53. Jain, 2002, Transdermal drug delivery of imipramine hydrochloride: I. Effect of terpenes, J. Control. Release, 79, 93, 10.1016/S0168-3659(01)00524-7 · DOI
  54. El-Kattan, 2000, The effect of terpene enhancer lipophilicity on the percutaneous permeation of hydrocortisone formulated in HPMC gel systems, Int. J. Pharm., 198, 179, 10.1016/S0378-5173(00)00330-6 · doi:10.1016/s0378-5173(00)00330-6
  55. Monti, 2002, Effect of different terpene-containing essential oils on permeation of estradiol through hairless mouse skin, Int. J. Pharm., 237, 209, 10.1016/S0378-5173(02)00032-7 · DOI
  56. Cal, 2001, In vitro studies on penetration of terpenes from matrix-type transdermal systems through human skin, Int. J. Pharm., 224, 81, 10.1016/S0378-5173(01)00744-X · doi:10.1016/s0378-5173(01)00744-x
  57. Cornwell, 1996, Modes of action of terpene penetration enhancers in human skin; differential scanning calorimetry, small-angle X-ray diffraction and enhancer uptake studies, Int. J. Pharm, 127, 9, 10.1016/0378-5173(95)04108-7 · DOI · Paper page
  58. Kato, 1987, Effect of egg-yolk lecithin on transdermal delivery of bunazosin hydrochloride, J. Pharm. Pharmacol., 39, 399, 10.1111/j.2042-7158.1987.tb03407.x · doi:10.1111/j.2042-7158.1987.tb03407.x
  59. Barry, 1991, Lipid–protein-partititioning theory of skin penetration enhancement, J. Control. Release, 15, 237, 10.1016/0168-3659(91)90115-T · DOI · Paper page

Cited by

See all 1,746

Metadata

Authors
Williams, A. C., & Barry, B. W.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2004-03
Volume
56
Issue
5
Pages
603-618
ISSN
0169-409X (ISSN-L)
DOI
10.1016/j.addr.2003.10.025
OpenAlex
W4240821889
Cited by
1,746
References
0
FWCI
2.81
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Penetration enhancers. https://app.cochat.ai/papers/10.1016/j.addr.2003.10.025
The paper
Williams, A. C., & Barry, B. W. (2004). Penetration enhancers. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2003.10.025

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.