Approaches for enhancing oral bioavailability of peptides and proteins

Physiology of the Gastrointestinal Tract

Johnson, L. R. (2006) · Elsevier eBooks · doi:10.1016/b978-0-12-088394-3.x5000-4 · Cited by 4,611 · see citing works

Hydrogels in pharmaceutical formulations

Peppas, N. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00090-4 · Cited by 4,011 · see citing works

Biodegradable nanoparticles for drug and gene delivery to cells and tissue

Panyam, J., & Labhasetwar, V. D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00228-4 · Cited by 3,365 · see citing works

Nanoparticle-based targeted drug delivery

Singh, R., & Lillard, J. W. (2009) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2008.12.004 · Cited by 2,745 · see citing works

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

Schwarze, S. R., Ho, A. L., Vocero-Akbani, A. M., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,418 · see citing works

Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization

Loftsson, Þ., & Brewster, M. E. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js950534b · Cited by 2,179 · see citing works

Cyclodextrins as pharmaceutical solubilizers

Brewster, M. E., & Loftsson, Þ. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.012 · Cited by 1,892 · see citing works

Penetration enhancers

Williams, A. C., & Barry, B. W. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.025 · Cited by 1,746 · see citing works

Prodrugs: design and clinical applications

Rautio, J., Kumpulainen, H., Heimbach, T., Oliyai, R., Oh, D.-M., Järvinen, T., & Savolainen, J. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2468 · Cited by 1,645 · see citing works

Skin penetration enhancers

Lane, M. E. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.040 · Cited by 1,486 · see citing works

Principles of Anatomy and Physiology

Baker, G. F., Tortora, G. J., & Nostakos, N. P. A. (1976) · AJN American Journal of Nursing · doi:10.2307/3423898 · Cited by 1,322 · see citing works

Cyclodextrins in drug delivery: An updated review

Challa, R., Ahuja, A., Ali, J., & Khar, R. K. (2005) · AAPS PharmSciTech · doi:10.1208/pt060243 · Cited by 1,215 · see citing works

Protein drug stability: a formulation challenge

Frøkjær, S., & Otzen, D. E. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1695 · Cited by 1,102 · see citing works

Nanoparticles in cellular drug delivery

Faraji, A. H., & Wipf, P. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.02.043 · Cited by 907 · see citing works

Solid lipid nanoparticles as a drug delivery system for peptides and proteins☆

Almeida, A. J., & Souto, E. B. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.04.007 · Cited by 817 · see citing works

Cell-penetrating peptides: mechanism and kinetics of cargo delivery

Zorko, M., & Langel, Ü. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.10.010 · Cited by 799 · see citing works

Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)

Artursson, P., Lindmark, T., Davis, S. S., & Illum, L. (1994) · Pharmaceutical Research · doi:10.1023/a:1018967116988 · Cited by 766 · see citing works

Mucoadhesive drug delivery systems

Donnelly, R. F., Shaikh, R., Singh, T. R. R., Garland, M. J., & Woolfson, A. D. (2011) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.76478 · Cited by 743 · see citing works

Biopharmaceutics and clinical pharmacokinetics

(1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90260-d · Cited by 693 · see citing works

Oral drug absorption enhancement by chitosan and its derivatives

Thanou, M., Verhoef, J. C., & Junginger, H. E. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00231-9 · Cited by 689 · see citing works

Cell-penetrating peptides: breaking through to the other side

Koren, E., & Torchilin, V. P. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.04.012 · Cited by 671 · see citing works

Pharmaceutical approaches to colon targeted drug delivery systems.

Chourasia, M. K., & Jain, S. (2003) · PubMed · Cited by 600 · see citing works

Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat

Pappenheimer, J. R., & Reiss, K. Z. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209145 · Cited by 527 · see citing works

Oral Delivery of Peptide Drugs

Hamman, J. H., Enslin, G. M., & Kotz, A. F. (2005) · BioDrugs · doi:10.2165/00063030-200519030-00003 · Cited by 504 · see citing works

Colloidal Drug Delivery Systems

Kreuter, J. (2014) · CRC Press eBooks · doi:10.1201/9781498710565 · Cited by 472 · see citing works

A New Approach to the Oral Administration of Insulin and Other Peptide Drugs

Saffran, M., Kumar, G. S., Savariar, C. M., Burnham, J. C., Williams, F. E., & Neckers, D. C. (1986) · Science · doi:10.1126/science.3526553 · Cited by 469 · see citing works

Vesicular systems in ocular drug delivery: an overview

Kaur, I. P., Garg, A. B., Singla, A. K., & Aggarwal, D. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.09.016 · Cited by 450 · see citing works

Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

Yin, L., Ding, J., He, C., Cui, L., Tang, C., & Yin, C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.055 · Cited by 449 · see citing works

Nanoparticles for oral delivery: Targeted nanoparticles with peptidic ligands for oral protein delivery

Yun, Y., Cho, Y. W., & Park, K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.007 · Cited by 443 · see citing works

P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

Varma, M. V. S. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00158-0 · Cited by 420 · see citing works

Colloidal drug delivery systems

Duncan‐Hewitt, W. C. (1995) · Colloids and Surfaces B Biointerfaces · doi:10.1016/0927-7765(95)90010-1 · Cited by 419 · see citing works

Oral delivery of insulin using pH‐responsive complexation gels

Lowman, A. M., Morishita, M., Kajita, M., NAGAI, T., & Peppas, N. A. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js980337n · Cited by 407 · see citing works

Carrier-Mediated Intestinal Transport of Drugs

Tsuji, A., & Tamai, I. (1996) · Pharmaceutical Research · doi:10.1023/a:1016086003070 · Cited by 392 · see citing works

Chitosans as Absorption Enhancers for Poorly Absorbable Drugs. 1: Influence of Molecular Weight and Degree of Acetylation on Drug Transport Across Human Intestinal Epithelial (Caco-2) Cells

Schipper, N. G. M., Vårum, K. M., & Artursson, P. (1996) · Pharmaceutical Research · doi:10.1023/a:1016444808000 · Cited by 384 · see citing works

A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery

Gratieri, T., Gelfuso, G. M., Rocha, E. M., Sarmento, V. H. V., de Freitas, O., & Lopez, R. F. V. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.02.011 · Cited by 377 · see citing works

Polymeric films as vehicle for buccal delivery: swelling, mechanical, and bioadhesive properties.

Peh, K. K., & Wong, C. F. (2000) · PubMed · Cited by 356 · see citing works

Emerging Trends in Oral Delivery of Peptide and Protein Drugs

Mahato, R. I., Narang, A. S., Thoma, L. A., & Miller, D. D. (2003) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v20.i23.30 · Cited by 352 · see citing works

Azoreductase activity of anaerobic bacteria isolated from human intestinal microflora

Rafii, F., Franklin, W., & Cerniglia, C. E. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.7.2146-2151.1990 · Cited by 340 · see citing works

Therapeutic application of peptides and proteins: parenteral forever?

Antošová, Z., Macková, M., Král, V., & Macek, T. (2009) · Trends in biotechnology · doi:10.1016/j.tibtech.2009.07.009 · Cited by 325 · see citing works

Effects of Various Protease Inhibitors on the Intestinal Absorption and Degradation of Insulin in Rats

Yamamoto, A., Taniguchi, T., Rikyuu, K., Tsuji, T., Fujita, T., Murakami, M., & Muranishi, S. (1994) · Pharmaceutical Research · doi:10.1023/a:1018968611962 · Cited by 321 · see citing works

Microbially triggered drug delivery to the colon

Sinha, V. R., & Kumria, R. (2003) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(02)00221-x · Cited by 317 · see citing works

Chitosan Capsules for Colon-Specific Drug Delivery: Improvement of Insulin Absorption from the Rat Colon

Tozaki, H., Komoike, J., Tada, C., Maruyama, T., Terabe, A., Suzuki, T., Yamamoto, A., & Muranishi, S. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js970018g · Cited by 315 · see citing works

The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins

Bernkop‐Schnürch, A. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00204-6 · Cited by 310 · see citing works

Absorption Enhancers: Applications and Advances

Aungst, B. J. (2011) · The AAPS Journal · doi:10.1208/s12248-011-9307-4 · Cited by 309 · see citing works

Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport

Jin, Y., Song, Y., Zhu, X., Zhou, D., Chen, C., Zhang, Z., & Huang, Y. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.075 · Cited by 301 · see citing works

Oral insulin delivery by means of solid lipid nanoparticles.

Sarmento, B. F. C. C., Martins, S., Ferreira, D., & Souto, E. B. (2007) · PubMed Central · Cited by 299 · see citing works

Cyclodextrins in peptide and protein delivery

Irie, T. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00057-x · Cited by 297 · see citing works

Chitosans as absorption enhancers of poorly absorbable drugs

Schipper, N. G. M., Vårum, K. M., Stenberg, P., Ocklind, G., Lennernäs, H., & Artursson, P. (1999) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(99)00032-9 · Cited by 278 · see citing works

Drug permeation enhancement via buccal route: possibilities and limitations

Şenel, S., & Hıncal, A. A. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00269-3 · Cited by 272 · see citing works

Biodegradable microparticles as controlled release antigen delivery systems.

O’Hagan, D. T., Rahman, D., McGee, J. P., Jeffery, H., Davies, M. C., Williams, P. M., Davis, S. S., & Challacombe, S. (1991) · PubMed Central · Cited by 270 · see citing works

Oral protein delivery: Current status and future prospect

Park, K., Kwon, I. C., & Park, K. (2010) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2010.10.002 · Cited by 266 · see citing works

Protein and peptide drug delivery: Oral approaches

Shaji, J., & Patole, V. (2008) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.42967 · Cited by 265 · see citing works

Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies

Pauletti, G. M. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00045-8 · Cited by 234 · see citing works

The American Psychiatric Publishing textbook of psychopharmacology

(2010) · Choice Reviews Online · doi:10.5860/choice.47-4164 · Cited by 233 · see citing works

The Influence of Peptide Structure on Transport Across Caco-2 Cells

Conradi, R. A., Hilgers, A. R., Ho, N. F. H., & Burton, P. S. (1991) · Pharmaceutical Research · doi:10.1023/a:1015825912542 · Cited by 228 · see citing works

Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan–EDTA conjugates

Bernkop‐Schnürch, A. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00136-3 · Cited by 223 · see citing works

Novel Drug Delivery Systems

Banerjee, P. S., & Robinson, J. R. (1991) · Clinical Pharmacokinetics · doi:10.2165/00003088-199120010-00001 · Cited by 222 · see citing works

Peroral Route: An Opportunity for Protein and Peptide Drug Delivery

Sood, A., & Panchagnula, R. (2001) · Chemical Reviews · doi:10.1021/cr000700m · Cited by 222 · see citing works

Recent Advances in Protein and Peptide Drug Delivery Systems

Malik, D. K., Baboota, S., Ahuja, A., Hasan, S., & Ali, J. (2007) · Current Drug Delivery · doi:10.2174/156720107780362339 · Cited by 216 · see citing works

Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery

Su, F.-Y., Lin, K., Sonaje, K., Wey, S., Yen, T., Ho, Y., Panda, N., Chuang, E., Maiti, B., & Sung, H. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.038 · Cited by 206 · see citing works

Chances and pitfalls of cell penetrating peptides for cellular drug delivery

Tréhin, R., & Merkle, H. P. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.02.018 · Cited by 200 · see citing works

Present and future of cell-penetrating peptide mediated delivery systems: “Is the Trojan horse too wild to go only to Troy?”

Vivès, É. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.032 · Cited by 196 · see citing works

Physiology of the Gastrointestinal Tract.

DeLor, C. J. (1969) · Archives of Internal Medicine · doi:10.1001/archinte.1969.00300170121031 · Cited by 192 · see citing works

Enhanced Oral Uptake of Tomato Lectin-Conjugated Nanoparticles in the Rat

Hussain, N., Jani, P. U., & Florence, A. T. (1997) · Pharmaceutical Research · doi:10.1023/a:1012153011884 · Cited by 191 · see citing works

Structures of archaebacterial membrane lipids

Sprott, G. D. (1992) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762348 · Cited by 189 · see citing works

Preactivated thiomers as mucoadhesive polymers for drug delivery

Iqbal, J., Shahnaz, G., Dünnhaupt, S., Muller, C. R., Hintzen, F., & Bernkop‐Schnürch, A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.021 · Cited by 187 · see citing works

Converting Peptides into Drug Leads by Lipidation

Zhang, L., & Bulaj, G. W. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712799945003 · Cited by 187 · see citing works

Oral delayed-release system for colonic specific delivery

Gazzaniga, A., Iamartino, P., Maffione, G., & Sangalli, M. E. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90418-9 · Cited by 183 · see citing works

Bioadhesive Polymers as Platforms for Oral Controlled Drug Delivery III: Oral Delivery of Chlorothiazide Using a Bioadhesive Polymer

Longer, M. A., Ch'Ng, H. S., & Robinson, J. R. (1985) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600740408 · Cited by 180 · see citing works

Effect of Size and Charge on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers via the Paracellular Pathway

Pauletti, G. M., Okumu, F. W., & Borchardt, R. T. (1997) · Pharmaceutical Research · doi:10.1023/a:1012040425146 · Cited by 177 · see citing works

Usefulness of cell-penetrating peptides to improve intestinal insulin absorption

Kamei, N., Morishita, M., Eda, Y., Ida, N., Nishio, R., & Takayama, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.08.001 · Cited by 177 · see citing works

How Structural Features Influence the Biomembrane Permeability of Peptides

Burton, P. S., Conradi, R. A., Ho, N. F. H., Hilgers, A. R., & Borchardt, R. T. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js960067d · Cited by 177 · see citing works

Folate-Decorated PLGA Nanoparticles as A Rationally Designed Vehicle for The Oral Delivery of Insulin

Jain, S., Rathi, V. V., Jain, A., Das, M., & Godugu, C. (2012) · Nanomedicine · doi:10.2217/nnm.12.31 · Cited by 175 · see citing works

Oral biodrug delivery using cell-penetrating peptide

Khafagy, E., & Morishita, M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.014 · Cited by 173 · see citing works

Evidence for a Polarized Efflux System in Caco-2 Cells Capable of Modulating Cyclosporine A Transport

Augustijns, P., Bradshaw, T., Gan, L., Hendren, R. W., & Thakker, D. R. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2487 · Cited by 172 · see citing works

A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery

García-Fuentes, M., Prego, C., Torres, D., & Alonso, M. J. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.02.008 · Cited by 171 · see citing works

Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers

Morishita, M., Lowman, A. M., Takayama, K., Nagai, T., & Peppas, N. A. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00019-6 · Cited by 170 · see citing works

A novel approach using functional peptides for efficient intestinal absorption of insulin

Morishita, M., Kamei, N., Ehara, J., Isowa, K., & Takayama, K. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.022 · Cited by 165 · see citing works

Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat

Kisel, M. A., Kulik, L. N., Tsybovsky, I. S., Vlasov, A. P., Vorobyov, M., Kholodova, E., & Zabarovskaya, Z. V. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00579-8 · Cited by 161 · see citing works

Particle uptake by Peyer’s patches: a pathway for drug and vaccine delivery

Shakweh, M., Ponchel, G., & Fattal, E. (2004) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.1.1.141 · Cited by 159 · see citing works

Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium

Salamat‐Miller, N., & Johnston, T. P. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.01.022 · Cited by 156 · see citing works

Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin–liposome nanocomplexes

Thirawong, N., Thongborisute, J., Takeuchi, H., & Sriamornsak, P. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.023 · Cited by 155 · see citing works

An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon

Zhang, H., Alsarra, I. A., & Neau, S. H. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00112-6 · Cited by 149 · see citing works

Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery

Bai, J. P. F., & Amidon, G. L. (1992) · Pharmaceutical Research · doi:10.1023/a:1015885823793 · Cited by 145 · see citing works

Evidence for a Polarized Efflux System for Peptides in the Apical Membrane of Caco-2 Cells

Burton, P. S., Conradi, R. A., Hilgers, A. R., & Ho, N. F. H. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1114 · Cited by 144 · see citing works

Silica nanoparticle coated liposomes: A new type of hybrid nanocapsule for proteins

Mohanraj, V. J., Barnes, T. J., & Prestidge, C. A. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.03.061 · Cited by 142 · see citing works

Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs

Cheng, J., Teply, B. A., Jeong, S. Y., Yim, C. H., Ho, D. C., Sherifi, I., Jon, S., Farokhzad, O. C., Khademhosseini, A., & Langer, R. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-9444-5 · Cited by 134 · see citing works

Controlled Release of Polypeptides and Other Macromolecules

Siegel, R. A., & Langer, R. (1984) · Pharmaceutical Research · doi:10.1023/a:1016318423563 · Cited by 133 · see citing works

Enhancement of Colonic Drug Absorption by the Transcellular Permeation Route

Tomita, M., Hayashi, M., Horie, T., Ishizawa, T., & Awazu, S. (1988) · Pharmaceutical Research · doi:10.1023/a:1015992819290 · Cited by 133 · see citing works

Delivery systems for penetration enhancement of peptide and protein drugs: design considerations.

Kompella, U. B., & Lee, V. H. L. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00137-x · Cited by 131 · see citing works

Effect of cell-penetrating peptides on the nasal absorption of insulin

Khafagy, E., Morishita, M., Isowa, K., Imai, J., & Takayama, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.09.076 · Cited by 130 · see citing works

Biodegradable microparticles for oral immunization

O’Hagan, D. T., McGee, J. P., Holmgren, J. R., Mowat, A. M., Donachie, A. M., Mills, K. H. G., Gaisford, W., Rahman, D., & Challacombe, S. (1993) · Vaccine · doi:10.1016/0264-410x(93)90011-l · Cited by 129 · see citing works

The intestinal absorption of some dipeptides

Newey, H. A., & Smyth, D. H. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006125 · Cited by 127 · see citing works

Plasma-treated PET surfaces improve the biocompatibility of human endothelial cells

Ramires, P. A., Mirenghi, L., Romano, A. R., Palumbo, F., & Nicolardi, G. (2000) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(20000905)51:3 · Cited by 127 · see citing works

Oral colon delivery of insulin with the aid of functional adjuvants

Maroni, A., Zema, L., Curto, M. D. D., Foppoli, A. A., & Gazzaniga, A. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.10.006 · Cited by 127 · see citing works

Prodrug Design to Improve Pharmacokinetic and Drug Delivery Properties: Challenges to the Discovery Scientists

Jana, S., Mandlekar, S., & Marathe, P. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710793205426 · Cited by 127 · see citing works

Reversible lipidization for the oral delivery of salmon calcitonin

Wang, J., Chow, D. D., Heiati, H., & Shen, W. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00008-7 · Cited by 125 · see citing works

Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency

Liang, J. F., & Yang, V. C.-M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.142 · Cited by 124 · see citing works

Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent

Bai, Y., Ann, D. K., & Shen, W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500062102 · Cited by 123 · see citing works

Oral Controlled Release Technology for Peptides: Status and Future Prospects

Fix, J. A. (1996) · Pharmaceutical Research · doi:10.1023/a:1016008419367 · Cited by 119 · see citing works

Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides

Kamei, N., Morishita, M., & Takayama, K. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.02.015 · Cited by 119 · see citing works

Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery

Vadlapudi, A. D., Vadlapatla, R. K., & Mitra, A. K. (2012) · Current Drug Targets · doi:10.2174/138945012800675650 · Cited by 119 · see citing works

Noninvasive routes of proteins and peptides drug delivery.

jitendra, Sharma, P. K., Bansal, S., & Banik, A. (2011) · Europe PMC (PubMed Central) · doi:10.4103/0250-474x.95608 · Cited by 117 · see citing works

The potential use of receptor-mediated endocytosis for oral drug delivery

Russell-Jones, G. J. (1996) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00131-p · Cited by 115 · see citing works

Targeted enteral delivery of insulin to rats

Touítou, E., & Rubinstein, A. (1986) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(86)90069-4 · Cited by 112 · see citing works

Thiomers: Preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system

Bernkop‐Schnürch, A., Weithaler, A., Albrecht-Schgoer, K., & Greimel, A. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.02.044 · Cited by 109 · see citing works

Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

Sharom, F. J., Yu, X., DiDiodato, G., & Chu, J. W. K. (1996) · Biochemical Journal · doi:10.1042/bj3200421 · Cited by 108 · see citing works

Bioadhesive interaction and hypoglycemic effect of insulin-loaded lectin–microparticle conjugates in oral insulin delivery system

Kim, B.-Y., Jeong, J. H., Park, K., & Kim, J.-D. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.032 · Cited by 108 · see citing works

Oral delivery of salmon calcitonin

Lee, Y.-H., & Sinko, P. J. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00063-6 · Cited by 108 · see citing works

Therapeutic Opportunities in Colon-Specific Drug-Delivery Systems

Patel, M. M., Shah, T. J., & Amin, A. F. (2007) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v24.i2.20 · Cited by 107 · see citing works

Chitosan-Coated Solid Lipid Nanoparticles for Insulin Delivery

Fonte, P., Andrade, F., Araújo, F., Andrade, C., das Neves, J., & Sarmento, B. F. C. C. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-391860-4.00015-x · Cited by 104 · see citing works

In vitro assessment of archaeosome stability for developing oral delivery systems

Patel, G. B., Agnew, B. J., Deschatelets, L., Fleming, L. P., & Sprott, G. D. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00331-2 · Cited by 104 · see citing works

Oral bioavailability and first-pass effects.

Kwan, K. C. (1997) · PubMed · Cited by 104 · see citing works

From sticky stuff to sweet receptors — achievements, limits and novel approaches to bioadhesion

Lehr, C. (1996) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03190262 · Cited by 103 · see citing works

Intestinal mucosal transport of insulin

Schilling, R. J., & Mitra, A. K. (1990) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(90)90030-8 · Cited by 99 · see citing works

Developments in the area of bioadhesive drug delivery systems

Lehr, C., & Haas, J. (2002) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2.3.287 · Cited by 98 · see citing works

Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers

Liu, D.-Z., LeCluyse, E. L., & Thakker, D. R. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js990094e · Cited by 96 · see citing works

Control of Postprandial Plasma Glucose by an Oral Insulin Product (HIM2) in Patients With Type 2 Diabetes

Kipnes, M. S., Dandona, P., Tripathy, D., Still, J., & Kosutic, G. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.421 · Cited by 96 · see citing works

Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins

Khafagy, E., Morishita, M., Kamei, N., Eda, Y., Ikeno, Y., & Takayama, K. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.07.022 · Cited by 94 · see citing works

In Vivo Evaluation of an Oral Salmon Calcitonin-Delivery System Based on a Thiolated Chitosan Carrier Matrix

Guggi, D., Kast, C. E., & Bernkop‐Schnürch, A. (2003) · Pharmaceutical Research · doi:10.1023/b:pham.0000008047.82334.7d · Cited by 93 · see citing works

Enhancement of Colonic Drug Absorption by the Paracellular Permeation Route

Tomita, M., Shiga, M., Hayashi, M., & Awazu, S. (1988) · Pharmaceutical Research · doi:10.1023/a:1015999309353 · Cited by 93 · see citing works

Novel complexation hydrogels for oral peptide delivery: In vitro evaluation of their cytocompatibility and insulin‐transport enhancing effects using Caco‐2 cell monolayers

Ichikawa, H., & Peppas, N. A. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10128 · Cited by 91 · see citing works

Azo compounds in colon-specific drug delivery

Roldo, M., Barbu, E., Brown, J. F., Laight, D. W., Smart, J. D., & Tsibouklis, J. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.5.547 · Cited by 90 · see citing works

Oral Delivery of Biologically Active Parathyroid Hormone

Leone‐Bay, A., Sato, M., Paton, D. R., Hunt, A. H., Sarubbi, D., Carozza, M., Chou, J., McDonough, J., & Baughman, R. (2001) · Pharmaceutical Research · doi:10.1023/a:1010936227570 · Cited by 87 · see citing works

INTESTINAL ABSORPTION OF INSULIN IN THE RAT

Danforth, E., & MOORE, R. O. (1959) · Endocrinology · doi:10.1210/endo-65-1-118 · Cited by 84 · see citing works

Oral Insulin Product Hexyl-Insulin Monoconjugate 2 (HIM2) in Type 1 Diabetes Mellitus: The Glucose Stabilization Effects of HIM2

Clement, S. C., Still, J., Kosutic, G., & McAllister, R. G. (2002) · Diabetes Technology & Therapeutics · doi:10.1089/152091502760306544 · Cited by 84 · see citing works

Chitosan: a potential polymer for colon-specific drug delivery system

Gulbake, A., & Jain, S. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.682148 · Cited by 84 · see citing works

The absorption of insulin from various regions of the rat intestine

Kidron, M., Bar-On, H., Berry, E. M., & Ziv, E. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90673-7 · Cited by 84 · see citing works

Cyclodextrins as Mucosal Absorption Promoters of Insulin. II. Effects of β-Cyclodextrin Derivatives on α-Chymotryptic Degradation and Enteral Absorption of Insulin in Rats

Shao, Z., Li, Y., Chermak, T., & Mitra, A. K. (1994) · Pharmaceutical Research · doi:10.1023/a:1018997101542 · Cited by 83 · see citing works

Investigation of archaeosomes as carriers for oral delivery of peptides

Li, Z., Chen, J., Sun, W., & Xu, Y. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.041 · Cited by 82 · see citing works

pH‐Sensitive Hydrogels as Gastrointestinal Tract Absorption Enhancers: Transport Mechanisms of Salmon Calcitonin and Other Model Molecules Using the Caco‐2 Cell Model

Torres‐Lugo, M., García-Fuentes, M., Record, R. D., & Peppas, N. A. (2002) · Biotechnology Progress · doi:10.1021/bp0101379 · Cited by 81 · see citing works

Complexation hydrogels for intestinal delivery of interferon β and calcitonin

Kamei, N., Morishita, M., Chiba, H., Kavimandan, N. J., Peppas, N. A., & Takayama, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.11.014 · Cited by 80 · see citing works

Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy.

Hurni, M. A., Noach, A. B. J., Blom-Roosemalen, M. C. M., Boer, A. G. D., Nagelkerke, J. F., & Breimer, D. D. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39367-5 · Cited by 80 · see citing works

Oral Colon-Specific Drug Delivery of Protein and Peptide Drugs

Sinha, V. R., Singh, A., Kumar, R. V., Singh, S. K., Kumria, R., & Bhinge, J. R. (2007) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v24.i1.30 · Cited by 79 · see citing works

Preparation and evaluation of mucinated sodium alginate microparticles for oral delivery of insulin

Builders, P. F., Kunle, O. O., Okpaku, L. C., Builders, M. I., Attama, A. A., & Adikwu, M. U. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.06.021 · Cited by 79 · see citing works

Improvement of Large Intestinal Absorption of Insulin by Chemical Modification with Palmitic Acid in Rats

Hashizume, M., Douen, T., Murakami, M., Yamamoto, A., Takada, K., & Muranishi, S. (1992) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1992.tb05463.x · Cited by 79 · see citing works

The potential use of receptor-mediated endocytosis for oral drug delivery1PII of original article: S0169_409X(96)00334-1. The article was originally published in Advanced Drug Delivery Reviews 20 (1996) 83–97.1

Russell-Jones, G. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00127-7 · Cited by 76 · see citing works

Optimizing oral absorption of peptides using prodrug strategies

Borchardt, R. T. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00042-5 · Cited by 74 · see citing works

Eudragit RS 100 microparticles containing 2-hydroxypropyl-β-cyclodextrin and glutathione: Physicochemical characterization, drug release and transport studies

Trapani, A., Laquintana, V., Denora, N., Lopedota, A. A., Cutrignelli, A., Franco, M., Trapani, G., & Liso, G. (2006) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2006.10.003 · Cited by 72 · see citing works

Polysaccharides: a targeting strategy for colonic drug delivery

Shah, N., Shah, T. J., & Amin, A. F. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.574121 · Cited by 72 · see citing works

Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells

Neill, M. J. O., Guo, J., Byrne, C. J., Darcy, R., & O’Driscoll, C. M. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.04.021 · Cited by 71 · see citing works

Strategic approaches for improving entrapment of hydrophilic peptide drugs by lipid nanoparticles

Yuan, H., Jiang, S., Du, Y., Miao, J., Zhang, X., & Hu, F. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.12.031 · Cited by 71 · see citing works

Colon Targeted Drug Delivery Systems -An Overview

Kumar, P., & Mishra, B. (2008) · Current Drug Delivery · doi:10.2174/156720108784911712 · Cited by 70 · see citing works

Critical review and synthesis of the epidemiologic evidence on formaldehyde exposure and risk of leukemia and other lymphohematopoietic malignancies

Checkoway, H., Boffetta, P., Mundt, D. J., & Mundt, K. A. (2012) · Cancer Causes & Control · doi:10.1007/s10552-012-0055-2 · Cited by 69 · see citing works

Use of Targeting Agents to Increase Uptake and Localization of Drugs to the Intestinal Epithelium

Russell-Jones, G. J. (2004) · Journal of drug targeting · doi:10.1080/10611860410001693760 · Cited by 66 · see citing works

Contribution of Cholesterol and Phospholipids to Inhibitory Effect of Dimethyl-β-Cyclodextrin on Efflux Function of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 in Vinblastine-Resistant Caco-2 Cell Monolayers

Arima, H., Yunomae, K., Morikawa, T., Hirayama, F., & Uekama, K. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000022409.27896.d4 · Cited by 64 · see citing works

Current Prodrug Design for Drug Discovery

Hsieh, P., Hung, C., & Fang, J. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682523 · Cited by 64 · see citing works

Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine

Yuan, L., Zhang, Z., Wei, C., Zhou, L., Wu, Q., & Chen (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s34991 · Cited by 62 · see citing works

Novel approaches for retinal drug delivery

Kurz, D. E., & Ciulla, T. A. (2002) · Ophthalmology Clinics of North America · doi:10.1016/s0896-1549(02)00034-2 · Cited by 61 · see citing works

Use of fluorescence imaging to investigate the structure and function of intestinal M cells

BUDA, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.07.014 · Cited by 59 · see citing works

Enhanced Absorption of Insulin and (Asu1,7)Eel‐Calcitonin using Novel Azopolymer‐Coated Pellets for Colon‐Specific Drug Delivery

Tozaki, H., Nishioka, J., Komoike, J., Okada, N., Fujita, T., Muranishi, S., Kim, S., Terashima, H., & Yamamoto, A. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/1520-6017(200101)90:1 · Cited by 59 · see citing works

Effect of Trypsin Inhibitor on Passage of Insulin Across the Intestinal Barrier

Laskowski, M. C., Haessler, H. A., Miech, R. P., Peanasky, R. J., & Laskowski, M. C. (1958) · Science · doi:10.1126/science.127.3306.1115 · Cited by 58 · see citing works

Role of efflux pumps and metabolising enzymes in drug delivery

Katragadda, S., Budda, B., Anand, B. S., & Mitra, A. K. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2.4.683 · Cited by 58 · see citing works

Enhanced transbuccal salmon calcitonin (sCT) delivery: Effect of chemical enhancers and electrical assistance on in vitro sCT buccal permeation

Oh, D.-H., Chun, K.-H., Jeon, S.-O., Kang, J. W., & Lee, S. K. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.05.010 · Cited by 58 · see citing works

Preparation and Characterization of Mono-PEGylated Epidermal Growth Factor: Evaluation of in Vitro Biologic Activity

Lee, H., & Park, T. G. (2002) · Pharmaceutical Research · doi:10.1023/a:1016113117851 · Cited by 57 · see citing works

Thiomers for oral delivery of hydrophilic macromolecular drugs

Bernkop‐Schnürch, A., Hoffer, M. H., & Kafedjiiski, K. (2004) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.1.1.87 · Cited by 57 · see citing works

Archaeosomes varying in lipid composition differ in receptor‐mediated endocytosis and differentially adjuvant immune responses to entrapped antigen

Sprott, G. D., Sad, S., Fleming, L. P., Dicaire, C. J., Patel, G. B., & Krishnan, L. (2002) · Archaea · doi:10.1155/2003/569283 · Cited by 56 · see citing works

Targeted lipid based drug conjugates: A novel strategy for drug delivery

Vadlapudi, A. D., Vadlapatla, R. K., Kwatra, D., Earla, R., Samanta, S., Pal, D., & Mitra, A. K. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.05.033 · Cited by 56 · see citing works

A mechanistic study on enhancement of rectal permeability to insulin in the albino rabbit.

Yamamoto, A., Hayakawa, E., Kato, Y., Nishiura, A., & Lee, V. H. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10333-9 · Cited by 55 · see citing works

Cutting-edge technologies in colon-targeted drug delivery systems

Patel, M. M. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.597739 · Cited by 54 · see citing works

WATCHING PEPTIDE DRUGS GROW UP

(2005) · Chemical & Engineering News · doi:10.1021/cen-v083n011.p017 · Cited by 54 · see citing works

Cyclodextrins — Useful excipients for oral peptide administration?

Haeberlin, B., Gengenbacher, T., Meinzer, A., & Fricker, G. (1996) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(96)04499-7 · Cited by 52 · see citing works

Passive Transepithelial Absorption of Thyrotropin-Releasing Hormone (TRH) via a Paracellular Route in Cultured Intestinal and Renal Epithelial Cell Lines

Thwaites, D. T., Hirst, B. H., & Simmons, N. L. (1993) · Pharmaceutical Research · doi:10.1023/a:1018947430018 · Cited by 51 · see citing works

Reversible lipidization for the oral delivery of leu-enkephalin

Wang, J., Hogenkamp, D. J., Tran, M. B., Li, W.-Y., Yoshimura, R. F., Johnstone, T. B. C., Shen, W., & Gee, K. W. (2006) · Journal of drug targeting · doi:10.1080/10611860600648221 · Cited by 51 · see citing works

The effect of additives on the oral mucosal absorption of human calcitonin in rats.

Nakada, Y., AWATA, N., NAKAMICHI, C., & SUGIMOTO, I. (1988) · Journal of Pharmacobio-Dynamics · doi:10.1248/bpb1978.11.395 · Cited by 49 · see citing works

The Effects of Backing Materials and Multilayered Systems on the Characteristics of Bioadhesive Buccal Patches

Guo, J., & Cooklock, K. M. (1996) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1996.tb05912.x · Cited by 48 · see citing works

In vitrointestinal transport of vasopressin and its analogues

Vilhardt, H., & LUNDIN, S. (1986) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1986.tb07861.x · Cited by 47 · see citing works

Oral Delivery System for Two-pulse Colonic Release of Protein Drugs and Protease Inhibitor/Absorption Enhancer Compounds

Curto, M. D. D., Maroni, A., Palugan, L., Zema, L., Gazzaniga, A., & Sangalli, M. E. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22560 · Cited by 47 · see citing works

ANTIDIURETIC ACTION OF 1-DEAMINO-[8-D-ARGININE]-VASOPRESSIN IN UNANESTHETIZED RATS

Vávra, I., Machová, A., & Krejčı́, I. (1974) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29745-2 · Cited by 47 · see citing works

Oral Drug Delivery and Delivery Systems

(1991) · Drugs and the pharmaceutical sciences · doi:10.1201/b14196-4 · Cited by 47 · see citing works

In Vivo Absorption Studies of Insulin from an Oral Delivery System

N Jerry, Y. A. (2001) · Drug Delivery · doi:10.1080/107175401300002711 · Cited by 45 · see citing works

Synthesis, Characterization and In Vivo Efficacy of PEGylated Insulin for Oral Delivery with Complexation Hydrogels

Tuesca, A. D., Reiff, C. M., Joseph, J. I., & Lowman, A. M. (2009) · Pharmaceutical Research · doi:10.1007/s11095-008-9816-8 · Cited by 43 · see citing works

Preactivated thiomers: Permeation enhancing properties

Wang, X., Iqbal, J., Rahmat, D., & Bernkop‐Schnürch, A. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.08.045 · Cited by 43 · see citing works

Modified bile acids as carriers for peptides and drugs

Kramer, W., Wess, G., Enhsen, A., Falk, E., Hoffmann, A., Neckermann, G., Schubert, G., & Urmann, M. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(96)01599-4 · Cited by 43 · see citing works

Anatomy and physiology of the gastrointestinal tract

Graaff, K. M. V. D. (1986) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198601001-00005 · Cited by 42 · see citing works

Principles of Pharmacokinetics and Pharmacodynamics

DeVane, C. L. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585623860.as08 · Cited by 41 · see citing works

Effects of Polyacrylic Polymers on the Degradation of Insulin and Peptide Drugs by Chymotrypsin and Trypsin

Bai, J. P. F., Chang, L. L., & Guo, J. (1996) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1996.tb05869.x · Cited by 40 · see citing works

Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs

Lim, C.-J., & Shen, W. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.05.001 · Cited by 39 · see citing works

Development of New Lipophilic Derivatives of Tetragastrin: Physicochemical Characteristics and Intestinal Absorption of Acyl-tetragastrin Derivatives in Rats

Tenma, T., Yodoya, E., Tashima, S., Fujita, T., Murakami, M., Yamamoto, A., & Muranishi, S. (1993) · Pharmaceutical Research · doi:10.1023/a:1018983511247 · Cited by 38 · see citing works

Quantification and Visualization of the Transport of Octreotide, a Somatostatin Analogue, Across Monolayers of Cerebrovascular Endothelial Cells

Jaehde, U., Masereeuw, R., Boer, A. G. D., Fricker, G., Nagelkerke, J. F., Vonderscher, J., & Breimer, D. D. (1994) · Pharmaceutical Research · doi:10.1023/a:1018929508018 · Cited by 37 · see citing works

Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood–brain barrier in vitro model

Navarro, C., González‐Álvarez, I., González‐Álvarez, M., Manku, M. S., Merino, V., Casabó, V. G., & Bermejo, M. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.12.005 · Cited by 37 · see citing works

The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery

Millotti, G., Perera, G., Vigl, C., Pickl, K. E., Sinner, F. M., & Bernkop‐Schnürch, A. (2010) · Drug Delivery · doi:10.3109/10717544.2010.522611 · Cited by 37 · see citing works

The Use of Cyclodextrins Nanoparticles for Oral Delivery

Kanwar, J. R., Long, B. M., & Kanwar, J. R. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711795656243 · Cited by 37 · see citing works

Intestinal Permeability Enhancement: Structure-Activity and Structure-Toxicity Relationships for Nonylphenoxypolyoxyethylene Surfactant Permeability Enhancers

Swenson, E. S., Milisen, W. B., & Curatolo, W. J. (1994) · Pharmaceutical Research · doi:10.1023/a:1018920728800 · Cited by 36 · see citing works

Modulation of Intestinal Permeability: An Innovative Method of Oral Drug Delivery for the Treatment of Inherited and Acquired Human Diseases

Fasano, A. (1998) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1998.2667 · Cited by 36 · see citing works

In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa.

LeCluyse, E. L., Sutton, S. C., & Fix, J. A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38218-2 · Cited by 35 · see citing works

Insulin-loaded poly(acrylic acid)-cysteine nanoparticles: Stability studies towards digestive enzymes of the intestine

Perera, G., Greindl, M., Palmberger, T. F., & Bernkop‐Schnürch, A. (2009) · Drug Delivery · doi:10.1080/10717540902937471 · Cited by 31 · see citing works

A preliminary study of corneal penetration of125l‐labelled idoxuridine liposome

Dharma, S. K., Fishman, P. H., & Peyman, G. A. (1986) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.1986.tb06923.x · Cited by 31 · see citing works

Mediation of trypsin inhibitor-induced pancreatic hypersecretion by secretin and cholecystokinin in rats

Watanabe, S., Takeuchi, T., & Chey, W. Y. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90111-b · Cited by 30 · see citing works

A Comparison of Thyrotropin-Releasing Hormone with Analogs: Influence of Disposition upon Pharmacology

Hichens, M. (1983) · Drug Metabolism Reviews · doi:10.3109/03602538308991382 · Cited by 30 · see citing works

Effects of sodium salicylate on epithelial cells of the rectal mucosa of the rat: A light and electron microscopic study

Sithigorngul, P., Burton, P. R., Nishihata, T., & Caldwell, L. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90656-2 · Cited by 30 · see citing works

Oral Protein Delivery: A Patent Review of Academic and Industrial Approaches

Werle, M., Makhlof, A., & Takeuchi, H. (2009) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/187221109788452221 · Cited by 30 · see citing works

Research Highlights: Highlights From The Latest Articles in Nanomedicine

Rubinstein, I. (2012) · Nanomedicine · doi:10.2217/nnm.12.38 · Cited by 30 · see citing works

In vitroevaluation of chondroitin sulphate-chitosan microspheres as carrier for the delivery of proteins

Maculotti, K., Tira, M. E., Sonaggere, M., Perugini, P., Conti, B., Modena, T., & Pavanetto, F. (2008) · Journal of Microencapsulation · doi:10.1080/02652040802485725 · Cited by 29 · see citing works

Functional expression of human P‐glycoprotein in Schizosaccharomyces pombe

Ueda, K., Shimabuku, A. M., Konishi, H., Fujii, Y., Takebe, S., Nishi, K., Yoshida, M., Beppu, T., & Komano, T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80888-2 · Cited by 29 · see citing works

Colon-specific delivery and enhanced colonic absorption of [Asu1,7]-eel calcitonin using chitosan capsules containing various additives in rats

Fetih, G. N., Fausia, H., Okada, N., Fujita, T., Attia, M., & Yamamoto, A. (2006) · Journal of drug targeting · doi:10.1080/10611860600648494 · Cited by 27 · see citing works

Amino-acids, Peptides, and Proteins

(1974) · Royal Society of Chemistry eBooks · doi:10.1039/9781847557292 · Cited by 23 · see citing works

Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and microporous membrane transport, part 2: diffusion studies

Chittchang, M., Salamat‐Miller, N., Alur, H. H., VanderVelde, D. G., Mitra, A. K., & Johnston, T. P. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235702108 · Cited by 23 · see citing works

Thiomers and thiomer-based nanoparticles in protein and DNA drug delivery

Hauptstein, S., & Bernkop‐Schnürch, A. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.697893 · Cited by 23 · see citing works

Basics and Recent Advances in Peptide and Protein Drug Delivery

Bruno, B. J., Miller, G. D., & Lim, C. S. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.104 · Cited by 760 · see citing works

Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles

Elmowafy, E. M., Tiboni, M., & Soliman, M. E. (2019) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-019-00439-x · Cited by 633 · see citing works

Physicochemical properties of mucus and their impact on transmucosal drug delivery

Leal, J., Smyth, H. D. C., & Ghosh, D. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.09.018 · Cited by 560 · see citing works

Thin films as an emerging platform for drug delivery

Karki, S., Kim, H., Na, S.-J., Shin, D., Jo, K., & Lee, J. (2016) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2016.05.004 · Cited by 544 · see citing works

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Date, A. A., Hanes, J. S., & Ensign, L. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.016 · Cited by 544 · see citing works

Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review

McClements, D. J. (2018) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2018.02.002 · Cited by 469 · see citing works

Orally Absorbed Cyclic Peptides

Nielsen, D. S., Shepherd, N. E., Xu, W., Lucke, A. J., Stoermer, M. J., & Fairlie, D. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00838 · Cited by 451 · see citing works

Current state and challenges in developing oral vaccines

Ramirez, J. E. V., Sharpe, L. A., & Peppas, N. A. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.008 · Cited by 410 · see citing works

Advances in Oral Drug Delivery Systems: Challenges and Opportunities

Lou, J., Duan, H., Qin, Q., Teng, Z., Gan, F., Zhou, X., & Zhou, X. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020484 · Cited by 403 · see citing works

Peptides with Dual Antimicrobial and Anticancer Activities

Felício, M. R., Silva, O. N., Gonçalves, S., Santos, N. C., & Franco, O. L. (2017) · Frontiers in Chemistry · doi:10.3389/fchem.2017.00005 · Cited by 393 · see citing works

Bioavailability of bioactive peptides derived from food proteins across the intestinal epithelial membrane: A review

Xu, Q., Hong, H., Wu, J., & Yan, X. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.02.050 · Cited by 372 · see citing works

Enzymatic hydrolysis and microbial fermentation: The most favorable biotechnological methods for the release of bioactive peptides

Cruz‐Casas, D. E., Aguilar, C. N., Ascacio-Valdés, J. A., Rodrı́guez-Herrera, R., Chávez‐González, M. L., & Flores‐Gallegos, A. C. (2021) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2021.100047 · Cited by 369 · see citing works

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Zhu, Q., Chen, Z., Paul, P. K., Lü, Y., Wu, W., & Qi, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.04.001 · Cited by 366 · see citing works

A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives

Muheem, A., Shakeel, F., Jahangir, M. A., Anwar, M., Mallick, N., Jain, G. K., Warsi, M. H., & Ahmad, F. J. (2014) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2014.06.004 · Cited by 343 · see citing works

Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals

McClements, D. J. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.08.004 · Cited by 322 · see citing works

Nanoparticles: Oral Delivery for Protein and Peptide Drugs

Cao, S., Xu, S., Wang, H., Ling, Y., Dong, J., Xia, R.-D., & Sun, X. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1325-z · Cited by 307 · see citing works

Current Evidence on the Bioavailability of Food Bioactive Peptides

Amigo, L., & Hernández-Ledesma, B. (2020) · Molecules · doi:10.3390/molecules25194479 · Cited by 311 · see citing works

Tutorial on monoclonal antibody pharmacokinetics and its considerations in early development

Ovacik, M., & Lin, K. (2018) · Clinical and Translational Science · doi:10.1111/cts.12567 · Cited by 299 · see citing works

Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides

Qian, Z., Martyna, A., Hard, R. L., Wang, J., Appiah‐Kubi, G., Coss, C. C., Phelps, M. A., Rossman, J. S., & Pei, D. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00226 · Cited by 298 · see citing works

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Moradi, S. V., Hussein, W. M., Varamini, P., Simerská, P., & Tóth, I. (2016) · Chemical Science · doi:10.1039/c5sc04392a · Cited by 289 · see citing works

Are intact peptides absorbed from the healthy gut in the adult human?

Miner-Williams, W. M., Stevens, B. R., & Moughan, P. J. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000225 · Cited by 290 · see citing works

Injectable Microfluidic Hydrogel Microspheres for Cell and Drug Delivery

Zhao, Z., Wang, Z., Li, G., Cai, Z., Wu, J., Wang, L., Deng, L., Cai, M., & Cui, W. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202103339 · Cited by 282 · see citing works

A review of natural polysaccharides for drug delivery applications: Special focus on cellulose, starch and glycogen

Gopinath, V., Sekaran, S., Al‐Maleki, A. R., Ramesh, M., & Vadivelu, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.136 · Cited by 281 · see citing works

Micro and nanoscale technologies in oral drug delivery

Ahadian, S., Finbloom, J. A., Mofidfar, M., Di̇ltemi̇z, S. E., Nasrollahi, F., Davoodi, E., Hosseini, V., Mylonaki, I., Sangabathuni, S., Montazerian, H., et al. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.012 · Cited by 271 · see citing works

Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin

Wong, C. Y. J., Al‐Salami, H., & Dass, C. R. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.12.036 · Cited by 271 · see citing works

Designing biopolymer microgels to encapsulate, protect and deliver bioactive components: Physicochemical aspects

McClements, D. J. (2016) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2016.12.005 · Cited by 267 · see citing works

Lipid-based nanocarriers for oral peptide delivery

Niu, Z., Conejos‐Sánchez, I., Griffin, B. T., O’Driscoll, C. M., & Alonso, M. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.001 · Cited by 266 · see citing works

Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications

Englert, C., Brendel, J. C., Majdanski, T. C., Yildirim, T., Schubert, S., Gottschaldt, M., Windhab, N., & Schubert, U. S. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.07.005 · Cited by 248 · see citing works

Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin

He, Z., Santos, J. L., Tian, H., Huang, H., Hu, Y., Liu, L., Leong, K. W., Chen, Y., & Mao, H. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.028 · Cited by 245 · see citing works

Advances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation

Gonçalves, R. F. S., Martins, J. T., Duarte, C. M. M., Vicente, A. A., & Pinheiro, A. C. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.06.011 · Cited by 242 · see citing works

Robust scalable high throughput production of monodisperse drops

Amstad, E., Chemama, M., Eggersdorfer, M. L., Arriaga, L. R., Brenner, M. P., & Weitz, D. A. (2016) · Lab on a Chip · doi:10.1039/c6lc01075j · Cited by 227 · see citing works

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

Mandal, A., Pal, D., Agrahari, V., Trinh, H. M., Joseph, M. A., & Mitra, A. K. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.01.008 · Cited by 224 · see citing works

Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges

Li, S., Zhang, H., Chen, K., Jin, M., Vu, S. H., Jung, S., He, N., Zhou, Z. G., & Lee, M. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2058646 · Cited by 221 · see citing works

Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Patel, A., Patel, M., Yang, X., & Mitra, A. K. (2014) · Protein and Peptide Letters · doi:10.2174/0929866521666140807114240 · Cited by 209 · see citing works

The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs

Wang, Y., Pi, C., Feng, X., Hou, Y., Zhao, L., & Wei, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s257269 · Cited by 201 · see citing works

Influence of peptide characteristics on their stability, intestinal transport, and in vitro bioavailability: A review

Wang, B., Xie, N., & Li, B. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12571 · Cited by 197 · see citing works

Bioactive peptides in plant-derived foodstuffs

Maestri, E., Marmiroli, M., & Marmiroli, N. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.03.048 · Cited by 192 · see citing works

Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets

Naylor, M. R., Bockus, A. T., Blanco, M.-J., & Lokey, R. S. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.04.012 · Cited by 187 · see citing works

Advanced progress of microencapsulation technologies: In vivo and in vitro models for studying oral and transdermal drug deliveries

Lam, P.-L., & Gambari, R. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.12.028 · Cited by 185 · see citing works

Oral delivery of insulin for treatment of diabetes: status quo, challenges and opportunities

Wong, C. Y. J., Martinez, J., & Dass, C. R. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12607 · Cited by 185 · see citing works

Recent Advancements in Non-Invasive Formulations for Protein Drug Delivery

Bajracharya, R., Song, J. G., Back, S. Y., & Han, H. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.09.004 · Cited by 183 · see citing works

Digestion and bioavailability of bioactive phytochemicals

Karaś, M., Jakubczyk, A., Szymanowska, U., Złotek, U., & Zielińska, E. (2016) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13323 · Cited by 182 · see citing works

An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Xu, Y., Shrestha, N., Véronique Préat, A., & Beloqui, A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.005 · Cited by 183 · see citing works

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

Jacob, S., Nair, A. B., Boddu, S. H. S., Gorain, B., Sreeharsha, N., & Shah, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081206 · Cited by 179 · see citing works

Considering food matrix and gastrointestinal effects in enhancing bioactive peptide absorption and bioavailability

Sun, X., Acquah, C., Aluko, R. E., & Udenigwe, C. C. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103680 · Cited by 178 · see citing works

A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases

Kathman, S. G., Xu, Z., & Statsyuk, A. V. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500345q · Cited by 173 · see citing works

Novel and revisited approaches in nanoparticle systems for buccal drug delivery

Macedo, A. S., Castro, P. M., Roque, L., Thomé, N. G., Reis, C. P., Pintado, M., & Fonte, P. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.006 · Cited by 173 · see citing works

Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment

Sonju, J. J., Dahal, A., Singh, S. S., & Jois, S. D. S. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.055 · Cited by 174 · see citing works

Laponite‐Based Nanomaterials for Drug Delivery

Kiaee, G., Dimitrakakis, N., Sharifzadeh, S., Kim, H., Avery, R. K., Mollazadeh‐Moghaddam, K., Haghniaz, R., Yalcintas, E. P., de Barros, N. R., Karamikamkar, S., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102054 · Cited by 170 · see citing works

Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins

Han, Y., Gao, Z., Chen, L., Kang, L., Huang, W., Jin, M., Wang, Q., & Bae, Y. H. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.01.004 · Cited by 165 · see citing works

Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

Lee, Y., Kamada, N., & Moon, J. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114021 · Cited by 168 · see citing works

Orally Active Peptides: Is There a Magic Bullet?

Räder, A. F. B., Weinmüller, M., Reichart, F., Schumacher‐Klinger, A., Merzbach, S., Gilon, C., Hoffman, A., & Kessler, H. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201807298 · Cited by 163 · see citing works

Recently isolated antidiabetic hydrolysates and peptides from multiple food sources: a review

Kehinde, B. A., & Sharma, P. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1528206 · Cited by 165 · see citing works

Docking small peptides remains a great challenge: an assessment using AutoDock Vina

Rentzsch, R., & Renard, B. Y. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv008 · Cited by 160 · see citing works

Targeting of gastrointestinal tract for amended delivery of protein/peptide therapeutics: Strategies and industrial perspectives

Pawar, V. K., Meher, J. G., Singh, Y., Chaurasia, M., Reddy, B. S., & Chourasia, M. K. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.09.031 · Cited by 154 · see citing works

Basic and recent advances in marine antihypertensive peptides: Production, structure-activity relationship and bioavailability

Abdelhedi, O., & Nasri, M. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.04.002 · Cited by 153 · see citing works

Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis

Rahimi, M., Charmi, G., Matyjaszewski, K. A., Banquy, X., & Pietrasik, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.01.003 · Cited by 152 · see citing works

In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin

Nielsen, E. J. B., Yoshida, S., Kamei, N., Iwamae, R., Khafagy, E., Olsen, J., Rahbek, U. L., Pedersen, B. L., Takayama, K., & Takeda‐Morishita, M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.022 · Cited by 151 · see citing works

A comprehensive review of bioactive peptides obtained from animal byproducts and their applications

Bechaux, J., Gatellier, P., Page, J. L., Drillet, Y., & Santé-Lhoutellier, V. (2019) · Food & Function · doi:10.1039/c9fo01546a · Cited by 150 · see citing works

Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems

Perry, S. L., & McClements, D. J. (2020) · Molecules · doi:10.3390/molecules25051161 · Cited by 148 · see citing works

Overcoming the Shortcomings of Peptide-Based Therapeutics

Lamers, C. (2022) · Future Drug Discovery · doi:10.4155/fdd-2022-0005 · Cited by 145 · see citing works

Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan

Jiang, T., Singh, B., Li, H.-S., Kim, Y.-K., Kang, S., Nah, J., Choi, Y., & Cho, C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.073 · Cited by 143 · see citing works

Challenges in delivering therapeutic peptides and proteins: A silk-based solution

Wu, J., Sahoo, J. K., Li, Y., Xu, Q., & Kaplan, D. L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.02.011 · Cited by 139 · see citing works

Polysaccharides constructed hydrogels as vehicles for proteins and peptides. A review

Drăgan, E. S., & Dinu, M. V. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115210 · Cited by 136 · see citing works

Efficacy, safety and cardiovascular outcomes of once‐daily oral semaglutide in patients with type 2 diabetes: The <scp>PIONEER</scp> programme

Thethi, T. K., Pratley, R., & Meier, J. J. (2020) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14054 · Cited by 134 · see citing works

A new era for oral peptides: SNAC and the development of oral semaglutide for the treatment of type 2 diabetes

Aroda, V. R., Blonde, L., & Pratley, R. E. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09735-8 · Cited by 135 · see citing works

Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery: Update on Clinical Advances

Baral, K. C., & Choi, K. Y. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17040397 · Cited by 135 · see citing works

Nanocarrier Fabrication and Macromolecule Drug delivery: Challenges and Opportunities

Agrahari, V., Agrahari, V., & Mitra, A. K. (2016) · Therapeutic Delivery · doi:10.4155/tde-2015-0012 · Cited by 133 · see citing works

pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery

Koetting, M. C., Guido, J. F., Gupta, M., Zhang, A., & Peppas, N. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.11.023 · Cited by 123 · see citing works

Oral delivery strategies for nutraceuticals: Delivery vehicles and absorption enhancers

Gleeson, J. P., Ryan, S. M., & Brayden, D. J. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.05.007 · Cited by 123 · see citing works

Fish skin gelatin hydrolysates as dipeptidyl peptidase IV inhibitors and glucagon-like peptide-1 stimulators improve glycaemic control in diabetic rats: A comparison between warm- and cold-water fish

Wang, T.-Y., Hsieh, C., Hung, C.-C., Jao, C., Chen, M., & Hsu, K. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.09.037 · Cited by 118 · see citing works

Biocompatible and Mucoadhesive Bacterial Cellulose-g-Poly(acrylic acid) Hydrogels for Oral Protein Delivery

Ahmad, N., Amin, M. C. I. M., Mahali, S. M., Ismail, I., & Chuang, V. T. G. (2014) · Molecular Pharmaceutics · doi:10.1021/mp5003015 · Cited by 118 · see citing works

Effects of pharmaceutical PEGylation on drug metabolism and its clinical concerns

Zhang, X., Wang, H., Ma, Z., & Wu, B. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.967679 · Cited by 117 · see citing works

Enzyme-Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review

Chai, T., Law, Y.-C., Wong, F., & Kim, S. (2017) · Marine Drugs · doi:10.3390/md15020042 · Cited by 116 · see citing works

Novel strategies in the oral delivery of antidiabetic peptide drugs – Insulin, GLP 1 and its analogs

Ismail, R., & Csóka, I. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.03.015 · Cited by 115 · see citing works

Protein based therapeutic delivery agents: Contemporary developments and challenges

Yin, L., Yuvienco, C., & Montclare, J. K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.036 · Cited by 112 · see citing works

An updated review on food‐derived bioactive peptides: Focus on the regulatory requirements, safety, and bioavailability

Patil, P. J., Usman, M. A., Zhang, C., Mehmood, A., Zhou, M., Teng, C., & Li, X. (2022) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12911 · Cited by 117 · see citing works

Benzothiazoles as potential antiviral agents

Asiri, Y. I., Alsayari, A., Muhsinah, A. B., Mabkhot, Y. N., & Hassan, M. Z. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13331 · Cited by 109 · see citing works

β-Lactoglobulin: An efficient nanocarrier for advanced delivery systems

Shafaei, Z., Ghalandari, B., Vaseghi, A., Divsalar, A., Haertlé, T., Saboury, A. A., & Sawyer, L. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.03.007 · Cited by 107 · see citing works

Plant‐Based Hollow Microcapsules for Oral Delivery Applications: Toward Optimized Loading and Controlled Release

Potroz, M. G., Mundargi, R. C., Gillissen, J. J. J., Tan, E., Meker, S., Park, J. H., Jung, H., Park, S.-H., Cho, D., Bang, S. I., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700270 · Cited by 107 · see citing works

Throughput enhancement of parallel step emulsifier devices by shear-free and efficient nozzle clearance

Stolovicki, E., Ziblat, R., & Weitz, D. A. (2017) · Lab on a Chip · doi:10.1039/c7lc01037k · Cited by 106 · see citing works

Peptides as drug delivery vehicles across biological barriers

Ghosh, D., Peng, X., Leal, J., & Mohanty, R. P. (2017) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-017-0374-0 · Cited by 106 · see citing works

Stimuli-responsive graphene-incorporated multifunctional chitosan for drug delivery applications: a review

Gooneh-Farahani, S., Naimi‐Jamal, M. R., & Naghib, S. M. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1556257 · Cited by 103 · see citing works

Chitosan Nanoparticles as Oral Drug Carriers

Guadarrama-Escobar, O. R., Serrano-Castañeda, P., Anguíano-Almazán, E., Vázquez‐Durán, A., Peña‐Juárez, M. C., Vera‐Graziano, R., Morales-Florido, M. I., Pérez, B. R., Rodríguez-Cruz, I. M., Miranda-Calderón, J. E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054289 · Cited by 103 · see citing works

Peptide Lipidation – A Synthetic Strategy to Afford Peptide Based Therapeutics

Kowalczyk, R., Harris, P. W. R., Williams, G. M., Yang, S., & Brimble, M. A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-66095-0_9 · Cited by 101 · see citing works

Bioactive Carbohydrates and Peptides in Foods: An Overview of Sources, Downstream Processing Steps and Associated Bioactivities

Hayes, M., & Tiwari, B. K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922485 · Cited by 101 · see citing works

Clinical Pharmacology and Interplay of Immune Checkpoint Agents: A Yin-Yang Balance

Géraud, A., Gougis, P., Vozy, A., Anquetil, C., Allenbach, Y., Romano, E., Funck‐Brentano, E., Moslehi, J. J., Johnson, D. B., & Salem, J. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-022820-093805 · Cited by 94 · see citing works

Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRASG12D inhibitors for cancer therapy

Issahaku, A. R., Mukelabai, N., Agoni, C., Rudrapal, M., Aldosari, S. M., Almalki, S. G., & Khan, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-22668-1 · Cited by 93 · see citing works

Oral Delivery of Protein Drugs Bioencapsulated in Plant Cells

Kwon, K., & Daniell, H. (2016) · Molecular Therapy · doi:10.1038/mt.2016.115 · Cited by 98 · see citing works

Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability

Birch, D., Christensen, M. V., Stærk, D., Franzyk, H., & Nielsen, H. M. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.09.015 · Cited by 95 · see citing works

Versatile spider venom peptides and their medical and agricultural applications

Saez, N. J., & Herzig, V. (2018) · Toxicon · doi:10.1016/j.toxicon.2018.11.298 · Cited by 95 · see citing works

Pectin based multi-particulate carriers for colon-specific delivery of therapeutic agents

Das, S. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120814 · Cited by 94 · see citing works

The Current and Promising Oral Delivery Methods for Protein- and Peptide-Based Drugs

Nicze, M., Borówka, M., Dec, A., Niemiec, A., Bułdak, Ł., & Okopień, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020815 · Cited by 95 · see citing works

Visible‐Light‐Promoted Stereoselective C(sp 3 )−H Glycosylation for the Synthesis of C ‐Glycoamino Acids and C ‐Glycopeptides

Qi, R., Wang, C., Ma, Z., Wang, H., Chen, Q., Liu, L., Pan, D., Ren, X., Wang, R., & Xu, Z. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202200822 · Cited by 93 · see citing works

Oral peptide delivery: challenges and the way ahead

Dubey, S. K., Parab, S., Dabholkar, N., Agrawal, M., Singhvi, G., Alexander, A., Bapat, R. A., & Kesharwani, P. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.01.001 · Cited by 92 · see citing works

Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery

Leonavičiǖtė, G., & Bernkop‐Schnürch, A. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1068287 · Cited by 90 · see citing works

Millet derived bioactive peptides: A review on their functional properties and health benefits

Majid, A., & G., P. P. C. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1686342 · Cited by 89 · see citing works

Soluble eggshell membrane protein-loaded chitosan/fucoidan nanoparticles for treatment of defective intestinal epithelial cells

Lee, M.-C., & Huang, Y. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.113 · Cited by 88 · see citing works

Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability

Tong, T., Wang, L., You, X., & Wu, J. (2020) · Biomaterials Science · doi:10.1039/d0bm01151g · Cited by 88 · see citing works

Design, characterisation, and bioefficiency of insulin–chitosan nanoparticles after stabilisation by freeze-drying or cross-linking

Diop, M., Auberval, N., Viciglio, A., Langlois, A., Bietiger, W., Mura, C., Péronet, C., Bekel, A., Julien-David, D., Zhao, M., et al. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.05.065 · Cited by 88 · see citing works

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Choonara, B. F., Choonara, Y. E., Kumar, P., Bijukumar, D. R., du Toit, L. C., & Pillay, V. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.07.006 · Cited by 314 · see citing works

Protein and peptide drug delivery: Oral approaches

Shaji, J., & Patole, V. (2008) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.42967 · Cited by 265 · see citing works

Strategies for overcoming multiple barriers of oral administration of protein and peptide therapeutics

Wang, X., Wang, K., Fang, Y., Zhang, Y., Yi, L., Li, X., Zhao, Q., Zhu, X., Cai, S., & Wan, L. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102763 · Cited by 13 · see citing works

Is the oral route possible for peptide and protein drug delivery?

Morishita, M., & Peppas, N. A. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.08.005 · Cited by 515 · see citing works

Emerging Trends in Oral Delivery of Peptide and Protein Drugs

Mahato, R. I., Narang, A. S., Thoma, L. A., & Miller, D. D. (2003) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v20.i23.30 · Cited by 352 · see citing works