The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
Open accessAbstract
The increasing prevalence of poorly soluble drugs in development provides notable risk of new products demonstrating low and erratic bioavailability with consequences for safety and efficacy, particularly for drugs delivered by the oral route of administration. Although numerous strategies exist for enhancing the bioavailability of drugs with low aqueous solubility, the success of these approaches is not yet able to be guaranteed and is greatly dependent on the physical and chemical nature of the molecules being developed. Crystal engineering offers a number of routes to improved solubility and dissolution rate, which can be adopted through an in-depth knowledge of crystallisation processes and the molecular properties of active pharmaceutical ingredients. This article covers the concept and theory of crystal engineering and discusses the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles. Also considered within this review is the influence of crystallisation conditions on crystal habit and particle morphology with potential implications for dissolution and oral absorption.
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Cites
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Cited by
Ma, D., Hettiarachchi, G., Nguyen, D., Zhang, B., Wittenberg, J. B., Zavalij, P. Y., Briken, V., & Isaacs, L. (2012) · Nature Chemistry · doi:10.1038/nchem.1326 · Cited by 451
Eutectics as improved pharmaceutical materials: design, properties and characterization
Cherukuvada, S., & Nangia, A. (2014) · Chem. Commun. · doi:10.1039/c3cc47521b · Cited by 296
Design of Functional Therapeutic Deep Eutectic Solvents Based on Choline Chloride and Ascorbic Acid
Silva, J. M., Reis, R. L., Paiva, A., & Duarte, A. R. C. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.8b01687 · Cited by 142
Heikkinen, A. T., Baneyx, G., Caruso, A., & Parrott, N. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.06.013 · Cited by 76
Metadata
- Authors
- Blagden, N., de Matas, M., Gavan, P. T., & York, P.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 59
- Issue
- 7
- Pages
- 617-630
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W1995008519
- Cited by
- 1,448
- References
- 40
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Blagden, N., de Matas, M., Gavan, P. T., & York, P. (2007). Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2007.05.011
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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