Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P.

doi:10.1007/s11095-006-9132-0

Cited by 1,910Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems

Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P.·2006·Pharmaceutical Research

DOI 10.1007/s11095-006-9132-0

Open this paper in CoChat — free account

Abstract

Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell are currently successfully used as pharmaceutical carriers for water-insoluble drugs and demonstrate a series of attractive properties as drug carriers. Among the micelle-forming compounds, amphiphilic copolymers, i.e., polymers consisting of hydrophobic block and hydrophilic block, are gaining an increasing attention. Polymeric micelles possess high stability both in vitro and in vivo and good biocompatibility, and can solubilize a broad variety of poorly soluble pharmaceuticals many of these drug-loaded micelles are currently at different stages of preclinical and clinical trials. Among polymeric micelles, a special group is formed by lipid-core micelles, i.e., micelles formed by conjugates of soluble copolymers with lipids (such as polyethylene glycol-phosphatidyl ethanolamine conjugate, PEG-PE). Polymeric micelles, including lipid-core micelles, carrying various reporter (contrast) groups may become the imaging agents of choice in different imaging modalities. All these micelles can also be used as targeted drug delivery systems. The targeting can be achieved via the enhanced permeability and retention (EPR) effect (into the areas with the compromised vasculature), by making micelles of stimuli-responsive amphiphilic block-copolymers, or by attaching specific targeting ligand molecules to the micelle surface. Immunomicelles prepared by coupling monoclonal antibody molecules to p-nitrophenylcarbonyl groups on the water-exposed termini of the micelle corona-forming blocks demonstrate high binding specificity and targetability. This review will discuss some recent trends in using micelles as pharmaceutical carriers.

Integrity signals

Registry

Crossref · 10.1007/s11095-006-9132-0

Cites

226 of 226 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Surfactant tends to form a supramolecular assembly known as a colloidal dispersion, with a small diameter in the range from 5 to 100 nm.
“Surfactant tends to form a supramolecular assembly known also as a colloidal dispersion, which has a small diameter in the range from 5 to 100 nm [29].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [29]

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139 · see citing works
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works
Surfactants and interfacial phenomena
Rosen, M. J., & Kunjappu, J. T. (2005) · Choice Reviews Online · doi:10.5860/choice.42-2832 · Cited by 5,402 · see citing works
Drug-like properties and the causes of poor solubility and poor permeability
Lipinski, C. A. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(00)00107-6 · Cited by 3,776 · see citing works
Foundations of Colloid Science
Hunter, R. J. (1987) · Cited by 3,721 · see citing works
Handbook of Pharmaceutical Excipients
Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (1994) · Cited by 3,501 · see citing works
Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene- b -poly(acrylic acid) Block Copolymers
Zhang, L., & Eisenberg, A. (1995) · Science · doi:10.1126/science.268.5218.1728 · Cited by 2,474 · see citing works
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4607 · Cited by 2,438 · see citing works
Self-citation
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030 · see citing works
Self-citation
Structure and design of polymeric surfactant-based drug delivery systems
Torchilin, V. P. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00299-1 · Cited by 1,824 · see citing works
Self-citation
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,706 · see citing works
Self-citation
Untitled work
(1989) · PubMed · Cited by 1,639 · see citing works
Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
Helmlinger, G., Yuan, F., Dellian, M., & Jain, R. K. (1997) · Nature Medicine · doi:10.1038/nm0297-177 · Cited by 1,629 · see citing works
Chemistry for peptide and protein PEGylation
Roberts, M. J., Bentley, M. D., & Harris, J. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00022-4 · Cited by 1,607 · see citing works
PEGylated nanoparticles for biological and pharmaceutical applications
Otsuka, H., Nagasaki, Y., & Kataoka, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00226-0 · Cited by 1,587 · see citing works
Block copolymer micelles: preparation, characterization and application in drug delivery
Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., & Leroux, J.-C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.034 · Cited by 1,498 · see citing works
Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00009-3 · Cited by 1,474 · see citing works
Nano-engineering block copolymer aggregates for drug delivery
Allen, C., Maysinger, D., & Eisenberg, A. (1999) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/s0927-7765(99)00058-2 · Cited by 1,358 · see citing works
Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.
Felgner, J. H., Kumar, R., Sridhar, C. N., Wheeler, C. J., Tsai, Y.-L., Border, R., Ramsey, P., Martin, M. U., & Felgner, P. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41980-6 · Cited by 1,313 · see citing works
Polymeric micelles—A new generation of colloidal drug carriers
Jones, M.-C., & Leroux, J.-C. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00039-9 · Cited by 1,256 · see citing works
Surfactants in Solution
Mittal, K. L. (1989) · Springer eBooks · doi:10.1007/978-1-4613-0839-3 · Cited by 1,208 · see citing works
PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
Ogris, M., Brunner, S., Schüller, S., Kircheis, R., & Wagner, E. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300900 · Cited by 1,178 · see citing works
Amphiphilic block copolymers for drug delivery
Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10397 · Cited by 1,078 · see citing works
Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS
Maeda, H., Sawa, T., & Konno, T. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00309-1 · Cited by 926 · see citing works
Pegylation
Harris, J. M., Martin, N., & Modi, M. (2001) · Clinical Pharmacokinetics · doi:10.2165/00003088-200140070-00005 · Cited by 913 · see citing works
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Yuan, F., Leunig, M., Huang, S. K., Berk, D. A., Papahadjopoulos, D., & Jain, R. K. (1994) · PubMed · Cited by 908 · see citing works
Block copolymer micelles as vehicles for drug delivery
Kataoka, K., Kwon Glenn, S., Masayuki, Y., Teruo, O., & Sakurai, Y. (1993) · Journal of Controlled Release · doi:10.1016/0168-3659(93)90172-2 · Cited by 878 · see citing works
Block copolymer micelles as long-circulating drug vehicles
Kwon, G. S., & Kataoka, K. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00031-2 · Cited by 825 · see citing works
Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies
Kim, T.-Y., Kim, D.-W., Chung, J.-Y., Shin, S. G., Kim, S.-C., Heo, D. S., Kim, N. K., & Bang, Y.-J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0655 · Cited by 821 · see citing works
The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres
Gref, R., Domb, A. J., Quellec, P., Blunk, T., Müller, R. H., Verbavatz, J., & Langer, R. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00026-4 · Cited by 820 · see citing works
Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy
Bae, Y., Nishiyama, N., Fukushima, S., Koyama, H., Yasuhiro, M., & Kataoka, K. (2005) · Bioconjugate Chemistry · doi:10.1021/bc0498166 · Cited by 742 · see citing works
Block copolymer micelles for delivery of gene and related compounds
Kakizawa, Y., & Kataoka, K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00017-0 · Cited by 739 · see citing works
Polymeric micelles as new drug carriers
Kwon, G. S., & Okano, T. (1996) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00401-2 · Cited by 711 · see citing works
Handbook of Pharmaceutical Excipients
Kibbe, A. H. (2003) · Medical Entomology and Zoology · Cited by 704 · see citing works
Pharmaceutical Dosage Forms and Drug Delivery Systems
Ansel, H. C., Allen, L. V., & Popovich, N. G. (1990) · Cited by 694 · see citing works
Transport of Molecules, Particles, and Cells in Solid Tumors
Jain, R. K. (1999) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.1.1.241 · Cited by 691 · see citing works
Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs
Lukyanov, A. N., & Torchilin, V. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.12.004 · Cited by 654 · see citing works
Self-citation
Polymeric micelle for tumor pH and folate-mediated targeting
Lee, E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00239-6 · Cited by 620 · see citing works
On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
Hafez, I., Maurer, N., & Cullis, P. R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301506 · Cited by 601 · see citing works
Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly (N-isopropylacrylamide) and poly (butylmethacrylate)
Chung, J. E., Yokoyama, M., Yamato, M., Aoyagi, T., Sakurai, Y., & Okano, T. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00029-2 · Cited by 599 · see citing works
Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor
Lee, E. S., Na, K., & Bae, Y. H. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.018 · Cited by 577 · see citing works
Development of the polymer micelle carrier system for doxorubicin
Nakanishi, T., Fukushima, S., Okamoto, K., Suzuki, M., Matsumura, Y., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00341-8 · Cited by 570 · see citing works
Targeted polymeric micelles for delivery of poorly soluble drugs
Torchilin, V. P. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4153-5 · Cited by 543 · see citing works
Self-citation
Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs
Torchilin, V. P., Lukyanov, A. N., Gao, Z., & Papahadjopoulos‐Sternberg, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931428100 · Cited by 538 · see citing works
Self-citation
Techniques of solubilization of drugs
Yalkowsky, S. H. (1981) · M. Dekker eBooks · Cited by 522 · see citing works
Surfactant Systems
Attwood, D., & Florence, A. J. (1983) · Springer eBooks · doi:10.1007/978-94-009-5775-6 · Cited by 520 · see citing works
Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds
Kwon, G. S. (2003) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v20.i5.20 · Cited by 502 · cited 1× · see citing works
“poly(ethylene glycol) (PEG) blocks with a molecular weight from 1 to 15 kDa as hydrophilic corona-forming blocks (60).”
Background
Novel Polyion Complex Micelles Entrapping Enzyme Molecules in the Core: Preparation of Narrowly-Distributed Micelles from Lysozyme and Poly(ethylene glycol)−Poly(aspartic acid) Block Copolymer in Aqueous Medium
Harada, A., & Kataoka, K. (1998) · Macromolecules · doi:10.1021/ma971277v · Cited by 482 · see citing works
Which polymers can make nanoparticulate drug carriers long-circulating?
Torchilin, V. P., & Trubetskoy, V. S. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00022-y · Cited by 480 · see citing works
Self-citation
PEG-based micelles as carriers of contrast agents for different imaging modalities
Torchilin, V. P. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00019-4 · Cited by 470 · see citing works
Self-citation
Micelle formation and solubilization of fluorescent probes in poly (oxyethylene-b-oxypropylene-b-oxyethylene) solutions
Kabanov, A. V., Nazarova, I. R., Astafieva, I. V., Batrakova, E. V., Alakhov, V. Y., Yaroslavov, A. A., & Kabanov, V. A. (1995) · Macromolecules · doi:10.1021/ma00111a026 · Cited by 459 · see citing works
Polymeric micelles for drug delivery
Aliabadi, H. M., & Lavasanifar, A. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.1.139 · Cited by 450 · see citing works
Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats
Uchino, H., Matsumura, Y., Negishi, T., Koizumi, F., Hayashi, T., Honda, T., Nishiyama, N., Kataoka, K., Naito, S., & Kakizoe, T. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602772 · Cited by 430 · see citing works
Medical Applications of Liposomes
(1998) · Elsevier eBooks · doi:10.1016/b978-0-444-82917-7.x5000-5 · Cited by 417 · see citing works
Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates
Kwon, G., Suwa, S., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90118-x · Cited by 409 · see citing works
Micelles based on AB block copolymers of poly (ethylene oxide) and poly (beta.-benzyl L-aspartate)
Kwon, G., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1993) · Langmuir · doi:10.1021/la00028a012 · Cited by 399 · see citing works
Untitled work
(1990) · PubMed · Cited by 398 · see citing works
Polymeric micellar pH-sensitive drug delivery system for doxorubicin
Hrubý, M., Koňák, Č., & Ulbrich, K. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.11.017 · Cited by 384 · see citing works
Preparation and Characterization of the Micelle-Forming Polymeric Drug Indomethacin-lncorporated Polyfethylene oxide)-Poly(β-benzyl L-aspartate) Block Copolymer Micelles
La, S. B., Okano, T., & Kataoka, K. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js950204r · Cited by 380 · see citing works
Folate-mediated targeting: from diagnostics to drug and gene delivery
Leamon, C. P., & Low, P. S. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(00)01594-4 · Cited by 377 · see citing works
Pluronic® block copolymers: novel functional molecules for gene therapy
Kabanov, A. V., Lemieux, P., Vinogradov, S. V., & Alakhov, V. Y. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00018-2 · Cited by 376 · see citing works
Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Monsky, W. L., Fukumura, D., Gohongi, T., Ancukiewcz, M., Weich, H. A., Torchilin, V. P., Yuan, F., & Jain, R. K. (1999) · PubMed · Cited by 369 · see citing works
Self-citation
Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers
Cammas‐Marion, S., Suzuki, K., Sone, C., Sakurai, Y., Kataoka, K., & Okano, T. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00040-0 · Cited by 355 · see citing works
Polycaprolactone–b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone
Allen, C. J. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00200-x · Cited by 352 · see citing works
Core-cross-linked polymeric micelles as paclitaxel carriers
Shuai, X., Merdan, T., Schaper, A. K., Xi, F., & Kissel, T. (2004) · Bioconjugate Chemistry · doi:10.1021/bc034113u · Cited by 333 · see citing works
Methoxy poly(ethylene glycol) and ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin.
Kim, S. Y., Shin, I. G., Lee, Y. M., Cho, C. S., & Sung, Y. K. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00124-7 · Cited by 330 · see citing works
Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound
Gao, Z., Fain, H. D., & Rapoport, N. Y. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.021 · Cited by 328 · see citing works
Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages
Yoo, H. S., Lee, E. A., & Park, T. G. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00088-3 · Cited by 324 · see citing works
Block copolymer micelles for drug delivery: loading and release of doxorubicin
Kwon, G. S., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00039-4 · Cited by 320 · see citing works
Polylactide−Poly(ethylene glycol) Copolymers as Drug Delivery Systems. 1. Characterization of Water Dispersible Micelle-Forming Systems
Hagan, S. A., Coombes, A. G. A., Garnett, M. C., Dunn, S. E., Davies, M. C., Illum, L., Davis, S. S., Harding, S. E., Purkiss, S. C., & Gellert, P. R. (1996) · Langmuir · doi:10.1021/la950649v · Cited by 319 · see citing works
Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery
Soga, O., van Nostrum, C. F., Fens, M., Rijcken, C. J. F., Schiffelers, R. M., Storm, G., & Hennink, W. E. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.009 · Cited by 319 · see citing works
Synthesis and evaluation of a star amphiphilic block copolymer from poly (ε-caprolactone) and poly (ethylene glycol) as a potential drug delivery carrier
Wang, F., Bronich, T. K., Kabanov, A. V., Rauh, R. D., & Roovers, J. (2005) · Bioconjugate Chemistry · doi:10.1021/bc049784m · Cited by 317 · see citing works
Interpolyelectrolyte and block ionomer complexes for gene delivery: physico-chemical aspects
Kabanov, A. V., & Kabanov, V. A. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00106-3 · Cited by 309 · see citing works
Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor
Yokoyama, M. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00115-6 · Cited by 308 · see citing works
The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles: Micelles as microcontainers for drug targeting
Kabanov, A. V., Chekhonin, V. P., Alakhov, V. Y., Batrakova, E. V., Lebedev, A. S., Melik-Nubarov, N. S., Arzhakov, S. A., Levashov, A. V., Morozov, G. V., Severin, E. S., et al. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81689-8 · Cited by 296 · see citing works
A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain
Kabanov, A. V., Batrakova, E. V., Melik-Nubarov, N. S., Fedoseev, N. A., Dorodnich, T. Y., Alakhov, V. Y., Chekhonin, V. P., Nazarova, I. R., & Kabanov, V. A. (1992) · Journal of Controlled Release · doi:10.1016/0168-3659(92)90199-2 · Cited by 295 · see citing works
Hydrotropic polymer micelle system for delivery of paclitaxel
Huh, K. M., Lee, S. C., Cho, Y. W., Lee, J., Jeong, J. H., & Park, K. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.003 · Cited by 291 · see citing works
Physical Entrapment of Adriamycin in AB Block Copolymer Micelles
Kwon, G. S., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1995) · Pharmaceutical Research · doi:10.1023/a:1016266523505 · Cited by 284 · see citing works
Polyethylene glycol–superoxide dismutase, a conjugate in search of exploitation
Veronese, F. M., Caliceti, P., Schiavon, O., & Sergi, M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00029-7 · Cited by 274 · see citing works
Polycaprolactone-<i>b</i>-poly(ethylene Oxide) Block Copolymer Micelles as a Novel Drug Delivery Vehicle for Neurotrophic Agents FK506 and L-685,818
Allen, C., Yu, Y., Maysinger, D., & Eisenberg, A. (1998) · Bioconjugate Chemistry · doi:10.1021/bc9702157 · Cited by 273 · see citing works
Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide)
Kohori, F., Sakai, K., Aoyagi, T., Yokoyama, M., Sakurai, Y., & Okano, T. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00023-6 · Cited by 273 · see citing works
p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups
Torchilin, V. P., Levchenko, T. S., Lukyanov, A. N., Khaw, B., Klibanov, A. L., Rammohan, R., Samokhin, G. P., & Whiteman, K. R. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2728(01)00165-7 · Cited by 271 · see citing works
Self-citation
Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactide-co-glycolide) with varying compositions
Liu, S. Q., Tong, Y. W., & Yang, Y.-Y. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.01.030 · Cited by 265 · see citing works
Diacyllipid-Polymer Micelles as Nanocarriers for Poorly Soluble Anticancer Drugs
Gao, Z., Lukyanov, A. N., Singhal, A., & Torchilin, V. P. (2002) · Nano Letters · doi:10.1021/nl025604a · Cited by 262 · see citing works
Self-citation
Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate)
Wei, H., Zhang, X., Zhou, Y., Cheng, S., & Zhuo, R. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.09.028 · Cited by 259 · see citing works
Water-Soluble Block Polycations as Carriers for Oligonucleotide Delivery
Kabanov, A. V., Vinogradov, S. V., Suzdaltseva, Y. G., & Alakhov, V. Y. (1995) · Bioconjugate Chemistry · doi:10.1021/bc00036a001 · Cited by 256 · see citing works
Liposome circulation time and tumor targeting: implications for cancer chemotherapy
Gabizón, A. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00030-b · Cited by 255 · see citing works
Poly (N-vinylpyrrolidone)-block-poly (D, L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation
Le Garrec, D., Gori, S., Luo, L., Lessard, D., Smith, D. C., Yessine, M.-A., Ranger, M., & Leroux, J.-C. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.06.018 · Cited by 255 · see citing works
Dendrimeric micelles for controlled drug release and targeted delivery
Ambade, A. V., Savariar, E. N., & Thayumanavan, S. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050020d · Cited by 245 · see citing works
Polymeric micelles of poly(2-ethyl-2-oxazoline)-block-poly(ε-caprolactone) copolymer as a carrier for paclitaxel
Lee, S. C., Kim, C., Kwon, I. C., Chung, H., & Jeong, S. Y. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00162-7 · Cited by 242 · see citing works
Folate-conjugated methoxy poly(ethylene glycol)/poly(ɛ-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery
Park, E. K., Kim, S. Y., Lee, S. B., & Lee, Y. M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.039 · Cited by 239 · see citing works
Cyclosporine A delivery to the eye: A pharmaceutical challenge
Lallemand, F., Felt-Baeyens, O., Besseghir, K., Béhar‐Cohen, F., & Gurny, R. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00138-3 · Cited by 239 · see citing works
A model of micellization for block copolymers in solutions
Gao, Z., & Eisenberg, A. (1993) · Macromolecules · doi:10.1021/ma00078a035 · Cited by 239 · see citing works
Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo
Torchilin, V. P., Shtilman, M. I., Trubetskoy, V. S., Whiteman, K. R., & Milstein, A. M. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90025-6 · Cited by 239 · see citing works
Self-citation
Anticancer Drug Development: Preclinical Screening, Clinical Trials and Approval
Selwood, D. L. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602070 · Cited by 238 · see citing works
Remarkable Increase in Nuclease Resistance of Plasmid DNA through Supramolecular Assembly with Poly(ethylene glycol)–Poly(l-lysine) Block Copolymer
Katayose, S., & Kataoka, K. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js970304s · Cited by 238 · see citing works
Polymer-coated long-circulating microparticulate pharmaceuticals
Torchilin, V. P. (1998) · Journal of Microencapsulation · doi:10.3109/02652049809006831 · Cited by 236 · see citing works
Self-citation
Introduction and overview of peptide and protein pegylation
Veronese, F. M., & Harris, J. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00020-0 · Cited by 235 · see citing works
The critical micelle concentration of l-α-dipalmitoylphosphatidylcholine in water and water/methanol solutions
Smith, R. W., & Tanford, C. (1972) · Journal of Molecular Biology · doi:10.1016/0022-2836(72)90387-7 · Cited by 231 · see citing works
Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity
Batrakova, E., Dorodnych, T. Y., Klinskii, E., Kliushnenkova, E., Шемчукова, О. Б., Goncharova, O., Arjakov, S., Alakhov, V., & Kabanov, A. V. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.587 · Cited by 228 · see citing works
Polyethylene Glycol-Diacyllipid Micelles Demonstrate Increased Accumulation in Subcutaneous Tumors in Mice
Lukyanov, A. N., Gao, Z., Mazzola, L. M., & Torchilin, V. P. (2002) · Pharmaceutical Research · doi:10.1023/a:1020488012264 · Cited by 227 · see citing works
Self-citation
Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness
Greenwald, R. B., Gilbert, C. W., Pendri, A., Conover, C. D., Xia, J., & Martinez, A. D. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950475e · Cited by 223 · see citing works
Clonazepam release from core-shell type nanoparticles in vitro
Jeong, Y.-I., Cheon, J., Kim, S.-H., Nah, J., Lee, Y.-M., Sung, Y. K., Akaike, T., & Cho, C.-S. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00163-6 · Cited by 221 · see citing works
pH-Sensitive Unimolecular Polymeric Micelles: Synthesis of a Novel Drug Carrier
Jones, M., Ranger, M., & Leroux, J. (2003) · Bioconjugate Chemistry · doi:10.1021/bc020041f · Cited by 217 · see citing works
Amphiphilic poly-N-vinylpyrrolidones:
Torchilin, V. P., Levchenko, T. S., Whiteman, K. R., Yaroslavov, A. A., Tsatsakis, A. M., Rizos, A. K., Michailova, E. V., & Shtilman, M. I. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00050-3 · Cited by 214 · see citing works
Self-citation
Selective Delivery of Adiramycin to a Solid Tumor Using a Polymeric Micelle Carrier System
Yokoyama, M., Okano, T., Sakurai, Y., Fukushima, S., Okamoto, K., & Kataoka, K. (1999) · Journal of drug targeting · doi:10.3109/10611869909085500 · Cited by 213 · see citing works
Micelles of methoxy poly(ethylene oxide)-b-poly(ɛ-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A
Aliabadi, H. M., Mahmud, A., Sharifabadi, A. D., & Lavasanifar, A. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.02.015 · Cited by 211 · see citing works
Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size
Yokoyama, M., Satoh, A., Sakurai, Y., Okano, T., Matsumura, Y., Kakizoe, T., & Kataoka, K. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00054-6 · Cited by 203 · see citing works
Preparation and biological properties of dichloro (1, 2-diaminocyclohexane) platinum (II)(DACHPt)-loaded polymeric micelles
Cabral, H., Nishiyama, N., Okazaki, S., Koyama, H., & Kataoka, K. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.022 · Cited by 201 · see citing works
Microparticulate Systems for the Delivery of Proteins and Vaccines
(2020) · CRC Press eBooks · doi:10.1201/9781003067542 · Cited by 199 · see citing works
Microparticulate systems for the delivery of proteins and vaccines
Lee, G. (1997) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(97)00045-3 · Cited by 199 · see citing works
Solubilization and Controlled Release of a Hydrophobic Drug Using Novel Micelle-Forming ABC Triblock Copolymers
Tang, Y., Liu, S., Armes, S. P., & Billingham, N. Ć. (2003) · Biomacromolecules · doi:10.1021/bm030026t · Cited by 199 · see citing works
Drug delivery in polymeric micelles: from in vitro to in vivo
Rapoport, N. Y. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00218-9 · Cited by 191 · see citing works
Polymeric micelles for delivery of poorly soluble drugs: Preparation and anticancer activityin vitroof paclitaxel incorporated into mixed micelles based on poly(ethylene glycol)-lipid conjugate and positively charged lipids
Wang, J., Mongayt, D., & Torchilin, V. P. (2005) · Journal of drug targeting · doi:10.1080/10611860400011935 · Cited by 183 · see citing works
Self-citation
Biodistribution of Micelle-Forming Polymer–Drug Conjugates
Kwon, G. S., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1993) · Pharmaceutical Research · doi:10.1023/a:1018998203127 · Cited by 180 · see citing works
Cationic liposome-mediated gene delivery: Biophysical study and mechanism of internalization
Almofti, M. R., Harashima, H., Shinohara, Y., Almofti, A., Baba, Y., & Kiwada, H. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00725-7 · Cited by 177 · see citing works
Increased accumulation of PEG–PE micelles in the area of experimental myocardial infarction in rabbits
Lukyanov, A. N., Hartner, W. C., & Torchilin, V. P. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.10.008 · Cited by 172 · see citing works
Self-citation
Block copolymer self-assembly in selective solvents: theory of solubilization in spherical micelles
Nagarajan, R., & Ganesh, K. (1989) · Macromolecules · doi:10.1021/ma00201a029 · Cited by 172 · see citing works
Sugar-Installed Block Copolymer Micelles: Their Preparation and Specific Interaction with Lectin Molecules
Nagasaki, Y., Yasugi, K., Yamamoto, Y., Harada, A., & Kataoka, K. (2001) · Biomacromolecules · doi:10.1021/bm015574q · Cited by 171 · see citing works
Accumulation of Protein-Loaded Long-Circulating Micelles and Liposomes in Subcutaneous Lewis Lung Carcinoma in Mice
Weissig, V., Whiteman, K. R., & Torchilin, V. P. (1998) · Pharmaceutical Research · doi:10.1023/a:1011951016118 · Cited by 170 · see citing works
Self-citation
New Synthetic Amphiphilic Polymers for Steric Protection of Liposomes in Vivo
Torchilin, V. P., Trubetskoy, V. S., Whiteman, K. R., Ferruti, P., Veronese, F. M., & Caliceti, P. (1995) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600840904 · Cited by 168 · see citing works
Self-citation
A Mixed Micellar Formulation Suitable for the Parenteral Administration of Taxol
Alkan-Önyüksel, H., Ramakrishnan, S., Chai, H., & Pezzuto, J. M. (1994) · Pharmaceutical Research · doi:10.1023/a:1018943021705 · Cited by 166 · see citing works
Novel Polymer Micelles Prepared from Chitosan Grafted Hydrophobic Palmitoyl Groups for Drug Delivery
Jiang, G., Quan, D., Liao, K., & Wang, H. (2006) · Molecular Pharmaceutics · doi:10.1021/mp050010c · Cited by 163 · see citing works
Mixed micelles in drug delivery
Lasiç, D. D. (1992) · Nature · doi:10.1038/355279a0 · Cited by 163 · see citing works
Interactions of Pluronic Block Copolymers with Brain Microvessel Endothelial Cells: Evidence of Two Potential Pathways for Drug Absorption
Miller, D. W., Batrakova, E. V., Waltner, T. O., Alakhov, V. Y., & Kabanov, A. V. (1997) · Bioconjugate Chemistry · doi:10.1021/bc970118d · Cited by 163 · see citing works
Novel pH-sensitive supramolecular assemblies for oral delivery of poorly water soluble drugs: preparation and characterization
Sant, V. P., Smith, D. C., & Leroux, J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.03.026 · Cited by 162 · see citing works
Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin
Dash, P. R., Read, M. L., Fisher, K., Howard, K. A., Wolfert, M. A., Oupický, D., Šubr, V., Strohalm, J., Ulbrich, K., & Seymour, L. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.3793 · Cited by 161 · see citing works
Ketorolac entrapped in polymeric micelles: preparation, characterisation and ocular anti-inflammatory studies
Gupta, A. K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00508-1 · Cited by 160 · see citing works
Mixed micelles made of poly(ethylene glycol)–phosphatidylethanolamine conjugate and d-α-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin
Li, M., ElBayoumi, T. A., & Torchilin, V. P. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.08.026 · Cited by 160 · see citing works
Self-citation
Phosphorylcholine-Based pH-Responsive Diblock Copolymer Micelles as Drug Delivery Vehicles: Light Scattering, Electron Microscopy, and Fluorescence Experiments
Giacomelli, C., Men, L. L., Borsali, R., Lai‐Kee‐Him, J., Brisson, A. R., Armes, S. P., & Lewis, A. L. (2006) · Biomacromolecules · doi:10.1021/bm0508921 · Cited by 160 · see citing works
Improved synthesis of adriamycin-conjugated poly (ethylene oxide)-poly (aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin
Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90237-2 · Cited by 154 · see citing works
Novel Polymeric Micelles Based on the Amphiphilic Diblock Copolymer Poly(N-vinyl-2-pyrrolidone)-block-poly(D,L-lactide)
Benahmed, A., Ranger, M., & Leroux, J. (2001) · Pharmaceutical Research · doi:10.1023/a:1011054930439 · Cited by 150 · see citing works
Sterically Stabilized Phospholipid Mixed Micelles: In Vitro Evaluation as a Novel Carrier for Water-Insoluble Drugs
Krishnadas, A., Rubinstein, I., & Önyüksel, H. (2003) · Pharmaceutical Research · doi:10.1023/a:1022243709003 · Cited by 150 · see citing works
Use of polyoxyethylene-lipid conjugates as long-circulating carriers for delivery of therapeutic and diagnostic agents
Trubetskoy, V. S., & Torchilin, V. P. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00032-3 · Cited by 148 · see citing works
Self-citation
An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs
Inoue, T., Chen, G., Nakamae, K., & Hoffman, A. S. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00172-7 · Cited by 146 · see citing works
Formation of Core−Shell Type Biodegradable Polymeric Micelles from Amphiphilic Poly(aspartic acid)-block-Polylactide Diblock Copolymer
Arimura, H., Ohya, Y., & Ouchi, T. (2005) · Biomacromolecules · doi:10.1021/bm0494491 · Cited by 144 · see citing works
Polyion Complex Micelles with Protein-Modified Corona for Receptor-Mediated Delivery of Oligonucleotides into Cells
Vinogradov, S. V., Batrakova, E. V., Li, S., & Kabanov, A. V. (1999) · Bioconjugate Chemistry · doi:10.1021/bc990037c · Cited by 143 · see citing works
Block Copolymer Design for Camptothecin Incorporation into Polymeric Micelles for Passive Tumor Targeting
Opanasopit, P., Yokoyama, M., Watanabe, M., Kawano, K., Maitani, Y., & Okano, T. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000048190.53439.eb · Cited by 141 · see citing works
Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent
Liu, J., Zeng, F., & Allen, C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.013 · Cited by 139 · see citing works
Polymeric micelles with a pH-responsive structure as intracellular drug carriers
Wang, C., Wang, C., & Hsiue, G. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.07.017 · Cited by 139 · see citing works
PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases
Calvo, P., Gouritin, B., Brigger, I., Lasmézas, C. I., Deslys, J., Williams, A., Andreux, J. P., Dormont, D., & Couvreur, P. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00450-2 · Cited by 136 · see citing works
Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution
Montazeri Aliabadi, H., Brocks, D. R., & Lavasanifar, A. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.042 · Cited by 132 · see citing works
Anticancer Drug Development Guide
(1997) · Humana Press eBooks · doi:10.1007/978-1-4615-8152-9 · Cited by 132 · see citing works
Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel
Constantinides, P. P., Lambert, K. J., Tustian, A. K., Schneider, B., Lalji, S., Ma, W., Wentzel, B., Kessler, D. R., Worah, D. M., & Quay, S. C. (2000) · Pharmaceutical Research · doi:10.1023/a:1007565230130 · Cited by 131 · see citing works
Preparation of camptothecin-loaded polymeric micelles and evaluation of their incorporation and circulation stability
Watanabe, M., Kawano, K., Yokoyama, M., Opanasopit, P., Okano, T., & Maitani, Y. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.030 · Cited by 128 · see citing works
Accumulation of Liposomal Lipid and Encapsulated Doxorubicin in Murine Lewis Lung Carcinoma: The Lack of Beneficial Effects by Coating Liposomes with Poly(ethylene glycol)
Parr, M. J., Masin, D., Cullis, P. R., & Bally, M. B. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36521-8 · Cited by 126 · see citing works
Stability and release performance of a series of pegylated copolymeric micelles
Lin, W.-J., Juang, L.-W., & Lin, C.-C. (2003) · Pharmaceutical Research · doi:10.1023/a:1023215320026 · Cited by 125 · see citing works
In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles
Liaw, J., Chang, S.-F., & Hsiao, F.-C. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301485 · Cited by 125 · see citing works
Diblock Copolymer Nanoparticles for Drug Delivery
Kwon, G. S. (1998) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v15.i5.20 · Cited by 124 · see citing works
CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles
Torchilin, V. P., Frank-Kamenetsky, M. D., & Wolf, G. L. (1999) · Academic Radiology · doi:10.1016/s1076-6332(99)80063-4 · Cited by 120 · see citing works
Self-citation
New micelle-like polymer aggregates made from PEI–PLGA diblock copolymers: micellar characteristics and cellular uptake
Nam, Y. S., Kang, H. S., Park, J. Y., Park, T. G., Han, S. H., & Chang, I. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00641-5 · Cited by 118 · see citing works
Photophysicals and photochemicals studies of zinc(II) phthalocyanine in long time circulation micelles for Photodynamic Therapy use
Sibata, M. N., Tedesco, A. C., & Marchetti, J. M. (2004) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2004.06.004 · Cited by 117 · see citing works
Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin
Morçöl, T., Nagappan, P., Nerenbaum, L., Mitchell, A., & Bell, S. J. D. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.07.015 · Cited by 112 · see citing works
Lactose-Installed Poly(ethylene glycol)−Poly( d , l -lactide) Block Copolymer Micelles Exhibit Fast-Rate Binding and High Affinity toward a Protein Bed Simulating a Cell Surface. A Surface Plasmon Resonance Study
Jule, E., Nagasaki, Y., & Kataoka, K. (2002) · Bioconjugate Chemistry · doi:10.1021/bc025598+ · Cited by 111 · see citing works
Colloidal carriers for controlled drug delivery and targeting : modification, characterization, and in vivo distribution
Müller, R. H. (1991) · Medical Entomology and Zoology · Cited by 107 · see citing works
Novel polymeric micelles for hydrophobic drug delivery based on biodegradable poly(hexyl-substituted lactides)
Trimaille, T., Mondon, K., Gurny, R., & Möller, M. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.03.036 · Cited by 107 · see citing works
Colloidal carriers for controlled drug delivery and targeting: Modification, characterization and in vivo distribution
Dressman, J. (1992) · Journal of Controlled Release · doi:10.1016/0168-3659(92)90174-p · Cited by 105 · see citing works
Copolymers of N‐isopropylacrylamide can trigger pH sensitivity to stable liposomes
Meyer, O., Papahadjopoulos, D., & Leroux, J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01520-2 · Cited by 105 · see citing works
Block-copolymer of Polyethylene Glycol and Polylysine as a Carrier of Organic Iodine: Design of Long-circulating Particulate Contrast Medium for X-ray Computed Tomography
Trubetskoy, V. S., Gazelle, G. S., Wolf, G. L., & Torchilin, V. P. (1997) · Journal of drug targeting · doi:10.3109/10611869709017895 · Cited by 105 · see citing works
Self-citation
Block copolymeric biotransport carriers as versatile vehicles for drug delivery
Alakhov, V. Y., & Kabanov, A. V. (1998) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.7.9.1453 · Cited by 104 · see citing works
PEG-PE/Phosphatidylcholine Mixed Immunomicelles Specifically Deliver Encapsulated Taxol to Tumor Cells of Different Origin and Promote their Efficient Killing
Gao, Z., Lukyanov, A. N., Chakilam, A. R., & Torchilin, V. P. (2003) · Journal of drug targeting · doi:10.1080/1061186031000138623 · Cited by 104 · see citing works
Self-citation
Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers
Moghimi, S. M. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00204-5 · Cited by 103 · see citing works
A liposomal MRI contrast agent: Phosphatid ylethanolamine‐DTPA
Grant, C. W. M., Karlik, S. J., & Florio, E. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910110211 · Cited by 103 · see citing works
Soluble Self-Assembled Block Copolymers for Drug Delivery
Kwon, G. S., & Okano, T. (1999) · Pharmaceutical Research · doi:10.1023/a:1011991617857 · Cited by 101 · see citing works
Folate Copolymer-Mediated Transfection of Cultured Cells
Leamon, C. P., Weigl, D., & Hendren, R. W. (1999) · Bioconjugate Chemistry · doi:10.1021/bc990066n · Cited by 101 · see citing works
Optimizing pH-responsive Polymeric Micelles for Drug Delivery in a Cancer Photodynamic Therapy Model
Garrec, D. L., Taillefer, J., van Lier, J. E., Lenaerts, V., & Leroux, J. (2002) · Journal of drug targeting · doi:10.1080/1061186021000001887 · Cited by 101 · see citing works
Intestinal uptake and biodistribution of novel polymeric micelles after oral administration
Mathot, F., van Beijsterveldt, L., Véronique Préat, A., Brewster, M. E., & Ariën, A. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.11.012 · Cited by 101 · see citing works
Human Plasma Distribution of Free Paclitaxel and Paclitaxel Associated with Diblock Copolymers
Ramaswamy, M., Zhang, X., Burt, H. M., & Wasan, K. M. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js960333n · Cited by 99 · see citing works
Preparation and characterization of water-soluble pH-sensitive nanocarriers for drug delivery
Dufresne, M.-H., Garrec, D. L., Sant, V. P., Leroux, J., & Ranger, M. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.07.014 · Cited by 98 · see citing works
Lipophilic β-adrenoceptor antagonists and local anesthetics are effective direct activators of g-proteins
Hageluken, A., Grünbaum, L., Nürnberg, B., Harhammer, R., Schunack, W. G., & Seifert, R. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90307-7 · Cited by 98 · see citing works
Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(l-lactide) diblock copolymer for application in drug delivery
Hsiue, G.-H., Wang, C., Lo, C.-L., Wang, C., Li, J., & Yang, J.-L. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.03.002 · Cited by 96 · see citing works
The mechanism of liposome accumulation in infarction
Palmer, T. N., Caride, V. J., Caldecourt, M. A., Twickler, J., & Abdullah, V. S. (1984) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(84)90258-7 · Cited by 95 · see citing works
Methoxy Poly(ethylene glycol)-block-Poly(δ-valerolactone) Copolymer Micelles for Formulation of Hydrophobic Drugs
Lee, H., Zeng, F., Dunne, M., & Allen, C. J. (2005) · Biomacromolecules · doi:10.1021/bm050451h · Cited by 95 · see citing works
Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: a case study with risperidone
Ould-Ouali, L., Noppe, M., Langlois, X., Willems, B., Riele, P. T., Timmerman, P., Brewster, M. E., Ariën, A., & Véronique Préat, A. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.022 · Cited by 95 · see citing works
Gadolinium‐labeled liposomes containing paramagnetic amphipathic agents: Targeted MRI contrast agents for the liver
Kabalka, G. W., Buonocore, E., Hübner, K. F., Davis, M. A. F., & Huang, L. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910080111 · Cited by 94 · see citing works
Enhancement of carboplatin toxicity by Pluronic block copolymers
Exner, A. A., Krupka, T. M., Scherrer, K., & Teets, J. M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.04.015 · Cited by 88 · see citing works
Synthesis and Characterization of mPEG−PLA Prodrug Micelles
Hans, M. L., Shimoni, K., Danino, D., Siegel, S. J., & Lowman, A. M. (2005) · Biomacromolecules · doi:10.1021/bm050188k · Cited by 86 · see citing works
Novel Taxol formulation: polyvinylpyrrolidone nanoparticle-encapsulated Taxol for drug delivery in cancer therapy.
Sharma, D., Chelvi, T. P., Kaur, J., Chakravorty, K., De, T., Maitra, A. N., & Ralhan, R. (1996) · PubMed · Cited by 84 · see citing works
A novel class of antitumor antibodies: nucleosome-restricted antinuclear autoantibodies (ANA) from healthy aged nonautoimmune mice.
Iakoubov, L. Z., & Vp, T. (1997) · PubMed · Cited by 82 · see citing works
N-Succinyl-(β-alanyl- l -leucyl- l -alanyl- l -leucyl)doxorubicin: An Extracellularly Tumor-Activated Prodrug Devoid of Intravenous Acute Toxicity
Fernandez, A.-M., derpoorten, K. V., Dasnois, L., Lebtahi, K., Dubois, V., Lobl, T. J., Gangwar, S., Oliyai, C., Lewis, E. R., Shochat, D., et al. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0108754 · Cited by 78 · see citing works
Polymeric Micelles Based on Amphiphilic Scorpion-like Macromolecules: Novel Carriers for Water-Insoluble Drugs
Djordjevic, J., Barch, M., & Uhrich, K. E. (2005) · Pharmaceutical Research · doi:10.1007/s11095-004-9005-3 · Cited by 74 · see citing works
Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy
Xu, P., Kirk, E. A. V., Li, S., Murdoch, W. J., Ren, J. T., Hussain, M. D., Radosz, M., & Shen, Y. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.01.004 · Cited by 73 · see citing works
Novel pH Sensitive Block Copolymer Micelles for Solvent Free Drug Loading
Shim, W. S., Kim, S. W., Choi, E., Park, H., Kim, J., & Lee, D. S. (2006) · Macromolecular Bioscience · doi:10.1002/mabi.200500182 · Cited by 72 · see citing works
Pegylated lysine based copolymeric dendritic micelles for solubilization and delivery of artemether.
Bhadra, D., Bhadra, S., & Jain, N. K. (2005) · PubMed · Cited by 72 · see citing works
Handbook of Targeted Delivery of Imaging Agents
Ponto, J. A. (1996) · Clinical Nuclear Medicine · doi:10.1097/00003072-199608000-00024 · Cited by 71 · see citing works
Potential application of poly(N-isopropylacrylamide) gel containing polymeric micelles to drug delivery systems
Hu, Y., & Tsujii, K. (2005) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2005.10.007 · Cited by 70 · see citing works
Relationships in the Structure–Tissue Distribution of Basic Drugs in the Rabbit
Yokogawa, K., Nakashima, E., Ishizaki, J., MAEDA, H., Nagano, T., & Ichimura, F. (1990) · Pharmaceutical Research · doi:10.1023/a:1015803202857 · Cited by 69 · see citing works
Handbook of targeted delivery of imaging agents
Torchilin, V. P. (1995) · CRC Press eBooks · Cited by 67 · see citing works
Self-citation
Structure—Function Relationship among Quillaja Saponins Serving as Excipients for Nasal and Ocular Delivery of Insulin
Pillion, D. J., Amsden, J. A., Kensil, C. R., & Recchia, J. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js9504651 · Cited by 67 · see citing works
Conjugates of poly(dl-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(β-cyclodextrin)s and their nanoparticles as protein delivery systems
Gao, H., Yang, Y., Fan, Y., & Ma, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.02.016 · Cited by 67 · see citing works
Biocompatibility studies on plasm polymerized interface materials encompassing both hydrophobic and hydrophilic surfaces
Johnson, S. D., Anderson, J. M., & Marchant, R. E. (1992) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820260707 · Cited by 65 · see citing works
Use of Block Copolymers of Poly(Ortho Esters) and Poly (Ethylene Glycol) Micellar Carriers as Potential Tumour Targeting Systems
Toncheva, V. D., Schacht, E. H., Ng, S. Y., Barr, J., & Heller, J. (2003) · Journal of drug targeting · doi:10.1080/10611860310001633839 · Cited by 64 · see citing works
Mixed Polymer Micelles of Amphiphilic and Cationic Copolymers for Delivery of Antisense Oligonucleotides
Vinogradov, S. V., Batrakova, E. V., Li, S., & Kabanov, A. V. (2004) · Journal of drug targeting · doi:10.1080/10611860400011927 · Cited by 61 · see citing works
Novel amphiphilic macromolecules and their in vitro characterization as stabilized micellar drug delivery systems
Tao, L., & Uhrich, K. E. (2006) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2005.12.018 · Cited by 60 · see citing works
Stable polymeric micelles: Lymphangiographic contrast media for gamma scintigraphy and magnetic resonance imaging
Trubetskoy, V. S., Frank-Kamenetsky, M. D., Whiteman, K. R., Wolf, G. L., & Torchilin, V. P. (1996) · Academic Radiology · doi:10.1016/s1076-6332(96)80448-x · Cited by 60 · see citing works
Self-citation
Block copolymeric biotransport carriers as versatile vehicles for drug delivery
Alakhov, V. Y., Lemieux, P., Klinski, E., Kabanov, A. V., & Pietrzyński, G. (2001) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.1.4.583 · Cited by 60 · see citing works
The influence of three poly(oxyethylene)poly(oxypropylene) surface-active block copolymers on the solubility behavior of indomethacin.
Lin, S., & Kawashimà, Y. (1985) · PubMed · Cited by 56 · see citing works
Reduction of the Side Effects of an Antitumor Agent, KRN5500, by Incorporation of the Drug into Polymeric Micelles
Matsumura, Y., Yokoyama, M., Kataoka, K., Okano, T., Sakurai, Y., Kawaguchi, T., & Kakizoe, T. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00675.x · Cited by 53 · see citing works
Cell Growth Inhibition by a Novel Vitamin K Is Associated with Induction of Protein Tyrosine Phosphorylation
Ni, R., Nishikawa, Y., & Carr, B. I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9906 · Cited by 53 · see citing works
Polycaprolactone-block-poly(ethylene oxide) Micelles: A Nanodelivery System for 17β-Estradiol
Soo, P. L., Lovrić, J., Davidson, P. M., Maysinger, D., & Eisenberg, A. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050049h · Cited by 49 · see citing works

Flagged first, then by citations

1 of the 227 references couldn’t be matched to a known paper.

Sorted by citations

Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710 · see citing works
Nanoparticles in Medicine: Therapeutic Applications and Developments
Zhang, L., Gu, F., Chan, J. M., Wang, A. Z., Langer, R., & Farokhzad, O. C. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,685 · see citing works
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201 · see citing works
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy
Pérez‐Herrero, E., & Fernández‐Medarde, A. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.018 · Cited by 1,888 · see citing works
Design of polymeric nanoparticles for biomedical delivery applications
Elsabahy, M., & Wooley, K. L. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15327k · Cited by 1,717 · see citing works
Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
Chen, G., Roy, I., Yang, C., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00148 · Cited by 1,507 · see citing works
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
Blagden, N., de Matas, M., Gavan, P. T., & York, P. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.011 · Cited by 1,452 · see citing works
Functionalizing Nanoparticles with Biological Molecules: Developing Chemistries that Facilitate Nanotechnology
Sapsford, K. E., Algar, W. R., Berti, L., Gemmill, K. B., Casey, B. J., Oh, E., Stewart, M. H., & Medintz, I. L. (2013) · Chemical Reviews · doi:10.1021/cr300143v · Cited by 1,429 · see citing works
Multifunctional nanoparticles for multimodal imaging and theragnosis
Lee, D., Koo, H., Sun, I., Ryu, J. H., Kim, K., & Kwon, I. C. (2011) · Chemical Society Reviews · doi:10.1039/c2cs15261d · Cited by 1,414 · see citing works
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350 · see citing works
Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270 · see citing works
Imaging and drug delivery using theranostic nanoparticles
Janib, S. M., Moses, A. S., & MacKay, J. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.08.004 · Cited by 1,249 · see citing works
Bioconjugated quantum dots for in vivo molecular and cellular imaging☆
SMITH, A., Duan, H., Mohs, A. M., & Nie, S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.015 · Cited by 1,196 · see citing works
Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery
Du, J., Du, X., Mao, C., & Wang, J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207150n · Cited by 1,176 · see citing works
Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
Maeda, H., Bharate, G. Y., & Daruwalla, J. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.11.010 · Cited by 1,171 · see citing works
Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy
Bisht, S., Feldmann, G., Soni, S., Ravi, R. K., Karikar, C., Maitra, A., & Maitra, A. (2007) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-5-3 · Cited by 1,091 · see citing works
Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic
Puri, A., Loomis, K. H., Smith, B. J., Lee, J. H., Yavlovich, A., Heldman, E., & Blumenthal, R. P. (2009) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v26.i6.10 · Cited by 1,075 · see citing works
Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform
Zhang, L., Chan, J. M., Gu, F., Rhee, J., Wang, A. Z., Radovic‐Moreno, A. F., Alexis, F., Langer, R., & Farokhzad, O. C. (2008) · ACS Nano · doi:10.1021/nn800275r · Cited by 1,042 · see citing works
Nanomedicine(s) under the Microscope
Duncan, R., & Gaspar, R. S. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200394t · Cited by 985 · see citing works
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
Oerlemans, C., Bult, W., Bos, M. A., Storm, G., Nijsen, J. F. W., & Hennink, W. E. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0233-4 · Cited by 951 · see citing works
Star Polymers
Ren, J. M., McKenzie, T. G., Fu, Q., Wong, E. H. H., Xu, J., An, Z., Shanmugam, S., Davis, T. P., Boyer, C. A., & Qiao, G. G. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00008 · Cited by 842 · see citing works
Click Chemistry, A Powerful Tool for Pharmaceutical Sciences
Hein, C. D., Liu, X.-M., & Wang, D. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9616-1 · Cited by 816 · see citing works
The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review
Wang, W., Sun, C., Mao, L., Ma, P., Liu, F., Yang, J., & Gao, Y. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.07.004 · Cited by 786 · see citing works
Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant
Barry, V., Winquist, A. G., & Steenland, K. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306615 · Cited by 781 · see citing works
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come
Yingchoncharoen, P., Kalinowski, D. S., & Richardson, D. R. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012070 · Cited by 744 · see citing works
PLGA–lecithin–PEG core–shell nanoparticles for controlled drug delivery
Chan, J. M., Zhang, L., Yuet, K. P., Liao, G., Rhee, J., Langer, R., & Farokhzad, O. C. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.013 · Cited by 705 · see citing works
Reactive‐Oxygen‐Species‐Responsive Drug Delivery Systems: Promises and Challenges
Saravanakumar, G., Kim, J., & Kim, W. J. (2016) · Advanced Science · doi:10.1002/advs.201600124 · Cited by 679 · see citing works
Semiconductor Quantum Dots for Bioimaging and Biodiagnostic Applications
Kairdolf, B. A., Smith, A. M., Stokes, T. H., Wang, M. D., Young, A. N., & Nie, S. (2013) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-060908-155136 · Cited by 674 · see citing works
Pharmaceutical cocrystals: An overview
Qiao, N., Li, M., Schlindwein, W. S., Malek, N., Davies, A., & Trappitt, G. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.07.037 · Cited by 668 · see citing works
Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy
Qin, W., Huang, G. J., Chen, Z., & Zhang, Y. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00001 · Cited by 656 · see citing works
Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
Torchilin, V. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.026 · Cited by 583 · see citing works
Self-citation
Polymeric Conjugates for Drug Delivery
Larson, N., & Ghandehari, H. (2012) · Chemistry of Materials · doi:10.1021/cm2031569 · Cited by 580 · see citing works
Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges
Wen, H., Jung, H., & Li, X. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9814-9 · Cited by 575 · see citing works
Functionalized micellar systems for cancer targeted drug delivery
Sutton, D., Nasongkla, N., Blanco, E., & Gao, J. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9223-y · Cited by 557 · see citing works
Polymeric micelles in cancer therapy: State of the art
Ghosh, B., & Biswas, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.016 · Cited by 553 · see citing works
Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals
Wang, S. F., Su, R., Nie, S., Sun, M., Zhang, J., Wu, D., & Moustaïd‐Moussa, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.10.002 · Cited by 532 · see citing works
The effects of polymeric nanostructure shape on drug delivery
Venkataraman, S., Hedrick, J. L., Ong, Z. Y., Yang, C. H., Ee, P. L. R., Hammond, P. T., & Yang, Y. Y. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.06.016 · Cited by 509 · see citing works
Polymeric Nanostructures for Imaging and Therapy
Elsabahy, M., Heo, G. S., Lim, S., Sun, G., & Wooley, K. L. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00135 · Cited by 507 · see citing works
Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery Across Biological Barriers
Kievit, F. M., & Zhang, M. (2011) · Advanced Materials · doi:10.1002/adma.201102313 · Cited by 495 · see citing works
Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
Mukherjee, A., Waters, A. K., Kalyan, P., Achrol, A. S., Kesari, S., & Yenugonda, V. M. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s198353 · Cited by 499 · see citing works
Hybrid Nanoparticles for Detection and Treatment of Cancer
Sailor, M. J., & Park, J. (2012) · Advanced Materials · doi:10.1002/adma.201200653 · Cited by 487 · see citing works
Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: An attractive tool for drug delivery
Rijcken, C. J. F., Soga, O., Hennink, W. E., & van Nostrum, C. F. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.03.023 · Cited by 487 · see citing works
Polymeric micelles for nano-scale drug delivery
Miyata, K., Christie, R. J., & Kataoka, K. (2010) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2010.10.009 · Cited by 478 · see citing works
Recent advances in polymeric micelles for anti-cancer drug delivery
Biswas, S., Kumari, P., Lakhani, P. M., & Ghosh, B. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.12.031 · Cited by 475 · see citing works
Multifunctional polymeric micelles for delivery of drugs and siRNA
Jhaveri, A. M., & Torchilin, V. P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00077 · Cited by 466 · see citing works
Self-citation
Self-assembling materials for therapeutic delivery
Branco, M. C., & Schneider, J. P. (2008) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.09.018 · Cited by 463 · see citing works
Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin
Sun, H., Guo, B., Cheng, R., Meng, F., Liu, H., & Zhong, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.051 · Cited by 438 · see citing works
Polymeric mixed micelles as nanomedicines: Achievements and perspectives
Cagel, M., Tesan, F. C., Bernabeu, E., Salgueiro, M. J., Zubillaga, M. B., Moretton, M. A., & Chiappetta, D. A. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.12.019 · Cited by 417 · see citing works
Nanoparticles and their applications in cell and molecular biology
Wang, E. C., & Wang, A. Z. (2013) · Integrative Biology · doi:10.1039/c3ib40165k · Cited by 418 · see citing works
Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
Zhou, Q., Zhang, L., Yang, T., & Wu, H. Y. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s158696 · Cited by 415 · see citing works
Cytokines as biomarkers of nanoparticle immunotoxicity
Elsabahy, M., & Wooley, K. L. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60064e · Cited by 408 · see citing works
Proton-Sponge Coated Quantum Dots for siRNA Delivery and Intracellular Imaging
Yezhelyev, M. V., Qi, L., O'Regan, R. M., Nie, S., & Gao, X. (2008) · Journal of the American Chemical Society · doi:10.1021/ja800086u · Cited by 406 · see citing works
Nanocarrier-based systems for targeted and site specific therapeutic delivery
Majumder, J., Taratula, O., & Minko, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.07.010 · Cited by 398 · see citing works
Delivery strategies for sustained drug release in the lungs
Loira-Pastoriza, C., Todoroff, J., & Rita Vanbever, A. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.017 · Cited by 395 · see citing works
PEGylation in anti-cancer therapy: An overview
Mishra, P., Nayak, B., & Dey, R. K. (2015) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2015.08.011 · Cited by 383 · see citing works
An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy
Mesquita, M. Q., Dias, C. J., Gamelas, S. R. D., Fardilha, M., Neves, M. G. P. M. S., & Faustino, M. A. F. (2018) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720170800 · Cited by 381 · see citing works
Rattle‐Type Fe3O4@SiO2 Hollow Mesoporous Spheres as Carriers for Drug Delivery
Zhu, Y., Ikoma, T., Hanagata, N., & Kaskel, S. (2009) · Small · doi:10.1002/smll.200901403 · Cited by 375 · see citing works
Polymeric micelles: nanocarriers for cancer-targeted drug delivery
Zhang, Y., Huang, Y., & Li, S. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0113-z · Cited by 367 · see citing works
Polymeric Delivery of Therapeutic Nucleic Acids
Kumar, R., Chalarca, C. F. S., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 370 · see citing works
Doxorubicin: nanotechnological overviews from bench to bedside
Cagel, M., Grotz, E., Bernabeu, E., Moretton, M. A., & Chiappetta, D. A. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.11.005 · Cited by 364 · see citing works
Nanoparticle contrast agents for computed tomography: a focus on micelles
Cormode, D. P., Naha, P. C., & Fayad, Z. A. (2014) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.1551 · Cited by 368 · see citing works
Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging
Algar, W. R., Massey, M., Rees, K., Higgins, R., Krause, K. D., Darwish, G. H., Peveler, W. J., Xiao, Z., Tsai, H.-Y., Gupta, R., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01176 · Cited by 361 · see citing works
Insights into Direct Nose to Brain Delivery: Current Status and Future Perspective
Mittal, D., Ali, A., Md, S., Baboota, S., Sahni, J. K., & Ali, J. (2014) · Drug Delivery · doi:10.3109/10717544.2013.838713 · Cited by 359 · see citing works
Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety
Zhu, L., Wang, T., Perche, F., Taigind, A., & Torchilin, V. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304987110 · Cited by 360 · see citing works
Self-citation
Nanomicellar formulations for sustained drug delivery: strategies and underlying principles
Trivedi, R., & Kompella, U. B. (2010) · Nanomedicine · doi:10.2217/nnm.10.10 · Cited by 358 · see citing works
Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks
Chen, Y., & Shi, J. (2016) · Advanced Materials · doi:10.1002/adma.201505147 · Cited by 357 · see citing works
Engineered polymers for advanced drug delivery
Kim, S., Kim, J., Jeon, O., Kwon, I. C., & Park, K. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.021 · Cited by 355 · see citing works
Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery
Majumder, J., & Minko, T. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1828339 · Cited by 353 · see citing works
Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability
Zheng, B., & McClements, D. J. (2020) · Molecules · doi:10.3390/molecules25122791 · Cited by 348 · see citing works
Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo
Song, Z., Feng, R., Sun, M. H., Guo, C., Gao, Y., Li, L., & Zhai, G. (2010) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2010.10.024 · Cited by 340 · see citing works
Amphiphilic Block Copolymers: Their Structures, and Self-Assembly to Polymeric Micelles and Polymersomes as Drug Delivery Vehicles
Kuperkar, K. C., Patel, D. D., Atanase, L. I., & Bahadur, P. (2022) · Polymers · doi:10.3390/polym14214702 · Cited by 341 · see citing works
A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems
Lu, H., Zhang, S., Wang, J., & Chen, Q. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.783831 · Cited by 336 · see citing works
Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies
Salcedo, J. M. M., Oza, G., Sharma, A. K., Arriaga, L., Hernández, J. M. H., Rotello, V. M., & Tapia-Ramı́rez, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17062078 · Cited by 337 · see citing works
Multifunctional Micellar Nanomedicine for Cancer Therapy
Blanco, E., Kessinger, C. W., Sumer, B. D., & Gao, J. (2008) · Experimental Biology and Medicine · doi:10.3181/0808-mr-250 · Cited by 330 · see citing works
Aggregation-induced Emission of Silole Molecules and Polymers: Fundamental and Applications
Liu, J., Lam, J. W. Y., & Tang, B. Z. (2009) · Journal of Inorganic and Organometallic Polymers and Materials · doi:10.1007/s10904-009-9282-8 · Cited by 331 · see citing works
<scp>pH</scp> ‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents
Karimi, M., Eslami, M., Sahandi‐Zangabad, P., Mirab, F., Farajisafiloo, N., Shafaei, Z., Ghosh, D., Bozorgomid, M., Dashkhaneh, F., & Hamblin, M. R. (2016) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1389 · Cited by 327 · see citing works
Targeting protein and peptide therapeutics to the heart via tannic acid modification
Shin, M., Lee, H.-A., Lee, M., Shin, Y., Song, J.-J., Kang, S.-W., Nam, D.-H., Jeon, E. J., Do, M., Do, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0227-9 · Cited by 325 · see citing works
Improvement of drug safety by the use of lipid-based nanocarriers
Lim, S. B., Banerjee, A., & Önyüksel, H. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.06.002 · Cited by 325 · see citing works
Mimicking the Cell: Bio-Inspired Functions of Supramolecular Assemblies
Tu, Y., Peng, F., Adawy, A., Men, Y., Abdelmohsen, L. K. E. A., & Wilson, D. A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00344 · Cited by 317 · see citing works
Poly(2‐Oxazoline)s – Are They More Advantageous for Biomedical Applications Than Other Polymers?
Sedláček, O., Monnery, B. D., Filippov, S. K., Hoogenboom, R., & Hrubý, M. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201200453 · Cited by 311 · see citing works
Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery
Li, Y., Xiao, K., Luo, J., Xiao, W., Lee, J. S., Gonik, A. M., Kato, J., Dong, T. A., & Lam, K. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.050 · Cited by 312 · see citing works
Anticancer nanomedicine and tumor vascular permeability; Where is the missing link?
Taurin, S., Nehoff, H. L., & Greish, K. F. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.07.013 · Cited by 309 · see citing works
Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305 · see citing works
PEG–Peptide Conjugates
Hamley, I. W. (2014) · Biomacromolecules · doi:10.1021/bm500246w · Cited by 301 · see citing works
Targeted nanodelivery of drugs and diagnostics
Phillips, M. A., Gran, M. L., & Peppas, N. A. (2010) · Nano Today · doi:10.1016/j.nantod.2010.03.003 · Cited by 297 · see citing works
Using Cocrystals To Systematically Modulate Aqueous Solubility and Melting Behavior of an Anticancer Drug
Aakeröy, C. B., Forbes, S., & Desper, J. A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja907674c · Cited by 297 · see citing works
Nanophotosensitizers toward advanced photodynamic therapy of Cancer
Lim, C., Heo, J., Shin, S., Jeong, K., Seo, Y. H., Jang, W., Park, C. R., Park, S. Y., Kim, S., & Kwon, I. C. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.09.012 · Cited by 293 · see citing works
Micelles structure development as a strategy to improve smart cancer therapy
Hanafy, N., El-Kemary, M., & Leporatti, S. (2018) · Cancers · doi:10.3390/cancers10070238 · Cited by 287 · see citing works
Nanomedicine in the diagnosis and therapy of neurodegenerative disorders
Kabanov, A. V., & Gendelman, H. E. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.014 · Cited by 277 · see citing works
Nanomicelles: types, properties and applications in drug delivery
Bose, A., Roy Burman, D., Sikdar, B., & Patra, P. (2021) · IET Nanobiotechnology · doi:10.1049/nbt2.12018 · Cited by 278 · see citing works
Biofunctionalized targeted nanoparticles for therapeutic applications
Wang, A. Z., Gu, F., Zhang, L., Chan, J. M., Radovic-Moreno, A., Shaikh, M. R., & Farokhzad, O. C. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.8.1063 · Cited by 272 · see citing works
Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review
Wang, Z., Deng, X., Ding, J., Zhou, W., Zheng, X., & Tang, G. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.003 · Cited by 271 · see citing works
Micro and nanoscale technologies in oral drug delivery
Ahadian, S., Finbloom, J. A., Mofidfar, M., Di̇ltemi̇z, S. E., Nasrollahi, F., Davoodi, E., Hosseini, V., Mylonaki, I., Sangabathuni, S., Montazerian, H., et al. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.012 · Cited by 271 · see citing works
Health impact and safety of engineered nanomaterials
Teow, Y., Asharani, P. V., Hande, M. P., & Valiyaveettil, S. (2011) · Chemical Communications · doi:10.1039/c0cc05271j · Cited by 270 · see citing works
Iodinated blood pool contrast media for preclinical X-ray imaging applications – A review
Hallouard, F., Anton, N., Choquet, P., Constantinesco, A., & Vandamme, T. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.066 · Cited by 267 · see citing works
Prospective of guar gum and its derivatives as controlled drug delivery systems
Prabaharan, M. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2011.04.022 · Cited by 251 · see citing works
PEGylated polymers for medicine: from conjugation to self-assembled systems
Joralemon, M. J., McRae, S., & Emrick, T. S. (2010) · Chemical Communications · doi:10.1039/b920570p · Cited by 252 · see citing works
Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery
Sun, T., Du, J., Yan, L., Mao, H., & Wang, J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.036 · Cited by 248 · see citing works
Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As Potential Carrier for Intracellular Drug Delivery
Tang, L., Wang, Y., Li, Y., Du, J., & Wang, J. (2009) · Bioconjugate Chemistry · doi:10.1021/bc900144m · Cited by 247 · see citing works
Nanocarriers and Their Loading Strategies
Wang, N., Cheng, X., Li, N., Wang, H., & Chen, H. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801002 · Cited by 248 · see citing works

Block copolymer micelles as a solution for drug delivery problems
Torchilin, V. P. (2005) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.15.1.63 · Cited by 68 · see citing works
Self-citation
Lipid-Core Micelles for Targeted Drug Delivery
Torchilin, V. P. (2005) · Current Drug Delivery · doi:10.2174/156720105774370221 · Cited by 179 · see citing works
Self-citation
Targeted polymeric micelles for delivery of poorly soluble drugs
Torchilin, V. P. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4153-5 · Cited by 543 · see citing works
Self-citation
Polymeric Micelles: Polyethylene Glycol-Phosphatidylethanolamine (PEG-PE)-Based Micelles as an Example
Sawant, R. R., & Torchilin, V. P. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-609-2_9 · Cited by 58 · see citing works
Self-citation
Polymeric Micelles for Drug Targeting and Delivery
Amin, M. C. I. M., Butt, A. M., Amjad, M. W., & Kesharwani, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809717-5.00006-3 · Cited by 52 · see citing works

Authors: Torchilin, V. P.
Affiliations: Northeastern University (US)
Corresponding author: Torchilin, V. P.
ORCID: Torchilin, V. P.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 2006-11-16
Volume: 24
Issue: 1
Pages: 1-16
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1007/s11095-006-9132-0
OpenAlex: W2016156919
Cited by: 1,910
References: 227
Citations by year: 2026: 52 · 2025: 80 · 2024: 70 · 2023: 68 · 2022: 88 · 2021: 99 · 2020: 94 · 2019: 68 · 2018: 98 · 2017: 115 · 2016: 144 · 2015: 140 · 2014: 126 · 2013: 142 · 2012: 133
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords: polymeric micelles, amphiphilic block copolymers, poorly water-soluble drugs, drug solubilization, targeted drug delivery, enhanced permeability and retention effect, stimuli-responsive polymers, targeting ligands, monoclonal antibody conjugation, nanocarriers
MeSH terms: Animals, Chemistry, Pharmaceutical, Contrast Media, Drug Carriers, Drug Compounding, Humans, Micelles, Polymers, Drug Delivery Systems, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Micellar Nanocarriers: Pharmaceutical Perspectives

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks