The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Polymeric nanoparticles for drug delivery to the central nervous system
Open accessAbstract
The central nervous system (CNS) poses a unique challenge for drug delivery. The blood-brain barrier significantly hinders the passage of systemically-delivered therapeutics and the brain extracellular matrix limits the distribution and longevity of locally-delivered agents. Polymeric nanoparticles represent a promising solution to these problems. Over the past 40 years, substantial research efforts have demonstrated that polymeric nanoparticles can be engineered for effective systemic and local delivery of therapeutics to the CNS. Moreover, many of the polymers used in nanoparticle fabrication are both biodegradable and biocompatible, thereby increasing the clinical utility of this strategy. Here, we review the major advances in the development of polymeric nanoparticles for drug delivery to the CNS.
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Citations
Cites
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Cited by
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Polymeric nanoparticles: A study on the preparation variables and characterization methods
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Polymeric nanoparticles: Promising platform for drug delivery
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Metadata
- Authors
- Patel, T., Zhou, J., Piepmeier, J. M., & Saltzman, W. M.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 64
- Issue
- 7
- Pages
- 701-705
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W1982471389
- Cited by
- 565
- References
- 61
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
