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Hydrogels for delivery of bioactive agents: A historical perspective
Open accessAbstract
Since 1960 when the history of modern hydrogels began significant progresses have been made in the field of controlled drug delivery. In particular, recent advances in the so-called smart hydrogels have made it possible to design highly sophisticated formulations, e.g., self-regulated drug delivery systems. Despite intensive efforts, clinical applications of smart hydrogels have been limited. Smart hydrogels need to be even smarter to execute functions necessary for achieving desired clinical functions. It is necessary to develop novel hydrogels that meet the requirements of the intended, specific applications, rather than finding applications of newly developed hydrogels. Furthermore, developing smarter hydrogels that can mimic natural systems is necessary, but the fundamental differences between natural and synthetic systems need to be understood. Such understanding will allow us to develop novel hydrogels with new, multiple functions we are looking for.
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Cites
Hydrophilic gels for biological use
WICHTERLE, O., & LÍM, D. (1960) · Nature · doi:10.1038/185117a0 · Cited by 2,996
Cited by
Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies
Chimene, D., Kaunas, R., & Gaharwar, A. K. (2020) · Advanced Materials · doi:10.1002/adma.201902026 · Cited by 600
El-Husseiny, H. M., Mady, E. A., Hamabe, L., Abugomaa, A., Shimada, K., Yoshida, T., Tanaka, T., Yokoi, A., Elbadawy, M., & Tanaka, R. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100186 · Cited by 533
Recent advances in hydrogel based drug delivery systems for the human body
Vashist, A., Vashist, A., Gupta, Y. K., & Ahmad, S. (2014) · J. Mater. Chem. B · doi:10.1039/c3tb21016b · Cited by 499
Stimuli-responsive hydrogels in drug delivery and tissue engineering
Sood, N., Bhardwaj, A., Mehta, S., & Mehta, A. (2016) · Drug Delivery · doi:10.3109/10717544.2014.940091 · Cited by 426
History and Applications of Hydrogels
Yahia, L. (2015) · Journal of Biomedical Sciencies · doi:10.4172/2254-609x.100013 · Cited by 339
Metadata
- Authors
- Lee, S. C., Kwon, I. K., & Park, K.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 65
- Issue
- 1
- Pages
- 17-20
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W1985753871
- Cited by
- 273
- References
- 1
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
