Stimuli-responsive hydrogels in drug delivery and tissue engineering
Open accessAbstract
Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natural polymers which can absorb and retain a significant amount of water. Hydrogels are one of the most studied classes of polymer-based controlled drug release. These have attracted considerable attention in biochemical and biomedical fields because of their characteristics, such as swelling in aqueous medium, biocompatibility, pH and temperature sensitivity or sensitivity towards other stimuli, which can be utilized for their controlled zero-order release. The hydrogels are expected to explore new generation of self-regulated delivery system having a wide array of desirable properties. This review highlights the exciting opportunities and challenges in the area of hydrogels. Here, we review different literatures on stimuli-sensitive hydrogels, such as role of temperature, electric potential, pH and ionic strength to control the release of drug from hydrogels.
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Anionic hydrogel-forming albumin can show pH-responsiveness by swelling in basic pH medium and shrinking in acidic pH.
“The anionic hydrogel forming albumin can show pH-responsiveness by swelling in basic pH medium and shrinking in acidic pH [27,81].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [27]
The pH-sensitive or ion-sensitive hydrogels section says an anionic polymer, polyacrylic acid, swells more at high pH, supporting the general pH-response pattern. It does not identify albumin as that polymer or establish that albumin hydrogels swell in basic conditions and shrink in acidic conditions (searched: albumin; albumin hydrogel swelling acidic basic pH). (LLM, conf=0.84)
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Flagged first, then by citations
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Cited by
Sorted by citations
Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application
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“The anionic hydrogel forming albumin can show pH-responsiveness by swelling in basic pH medium and shrinking in acidic pH [27,81].”
Background
- Authors
- Sood, N., Bhardwaj, A., Mehta, S., & Mehta, A.
- Affiliations
- Nanomedicine Research Centre, ISF College of Pharmacy Ferozepur, Moga, Punjab, India
- Corresponding author
- Mehta, Abhinav
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2014-07-21
- Volume
- 23
- Issue
- 3
- Pages
- 748-770
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- OpenAlex
- W2029061676
- Cited by
- 426
- References
- 175
- Citations by year
- 2026: 45 · 2025: 45 · 2024: 52 · 2023: 54 · 2022: 47 · 2021: 50 · 2020: 50 · 2019: 31 · 2018: 27 · 2017: 17 · 2016: 3 · 2015: 4 · 2014: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Keywords
- stimuli-responsive hydrogels, controlled drug release, tissue engineering, thermosensitive hydrogel, pH-responsive hydrogels, ionic strength sensitivity, electric potential, swelling, biocompatibility
- MeSH terms
- Animals, Humans, Hydrogen-Ion Concentration, Polymers, Temperature, Drug Delivery Systems, Hydrogels, Tissue Engineering
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