The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
Open accessAbstract
SPL is a highly conserved enzyme responsible for the irreversible degradation of the bioactive lipid, S1P. SPL regulates intracellular pools of S1P available for ligation of its five receptors and as such has a strong influence upon autocrine, paracrine and distant S1P signaling events. SPL is differentially expressed in mammalian tissues, is itself highly regulated at transcriptional and posttranslational levels, and requires oligomerization for normal function. Inhibitors are being developed to SPL, which may be useful therapeutic agents for a variety of diseases in which S1P has been implicated, including cancer, autoimmune disorders and inflammation.
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Cites
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581
Bioactive sphingolipids: metabolism and function
Bartke, N., & Hannun, Y. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800080-jlr200 · Cited by 683
Sphingosine 1-Phosphate Receptor Signaling
Rosen, H., Gonzalez-Cabrera, P. J., Sanna, M. G., & Brown, S. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.103733 · Cited by 404
Normalization of diabetic wound healing
Francis-Goforth, K. N., Harken, A. H., & Saba, J. D. (2010) · Surgery · doi:10.1016/j.surg.2009.04.038 · Cited by 29
Self-citation
Cited by
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
Merrill, A. H. (2011) · Chemical Reviews · doi:10.1021/cr2002917 · Cited by 785
An update on sphingosine-1-phosphate and other sphingolipid mediators
Fyrst, H., & Saba, J. D. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.392 · Cited by 344
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Metadata
- Authors
- Serra, M., & Saba, J. D.
- Venue
- Advances in Enzyme Regulation
- Publisher
- Elsevier BV
- Published
- 2010
- Volume
- 50
- Issue
- 1
- Pages
- 349-362
- ISSN
- 0065-2571 (ISSN-L)
- OpenAlex
- W2038891352
- Cited by
- 177
- References
- 4
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Serra, M., & Saba, J. D. (2010). Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Advances in Enzyme Regulation. https://doi.org/10.1016/j.advenzreg.2009.10.024
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
