Bioactive sphingolipids: metabolism and function
Open accessAbstract
Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural roles in cellular membranes, some metabolites, including ceramide, sphingosine, and sphingosine-1-phosphate, have drawn attention as bioactive signaling molecules involved in the regulation of cell growth, differentiation, senescence, and apoptosis. Understanding the many cell regulatory functions of SL metabolites requires an advanced knowledge of how and where in the cell they are generated, converted, or degraded. This review will provide a short overview of the metabolism, localization, and compartmentalization of SLs. Also, a discussion on bioactive members of the SL family and inducers of SL enzymes that lead to ceramide generation will be presented.
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Ceramides are bioactive sphingolipids involved in cell signaling, apoptosis, and membrane structure, and play a critical role in neurodegenerative diseases like Alzheimer's disease.
“Cers are bioactive sphingolipids involved in cell signaling, apoptosis, and membrane structure, playing a critical role in neurodegenerative diseases like AD. 22 , 23”
From Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes (2025) · cites this paper as [22]
The Abstract identifies ceramide as a bioactive sphingolipid and describes sphingolipids’ roles in membrane structure and signaling. “SLs as Bioactive Molecules” links ceramide signaling to apoptosis. But “Inducers of SL Enzymes” says ceramide has been linked to Alzheimer’s disease and neurodegeneration and may mediate an amyloid-β response; it does not establish the claimed critical role. (LLM, conf=0.88)
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Functional rafts in cell membranes
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“namically cluster with sterols to form lipid microdomains or rafts, which function as hubs for effective signal transduction and protein sorting (1).”
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Chipuk, J. E., McStay, G. P., Bharti, A., Kuwana, T., Clarke, C. J., Siskind, L. J., Obeid, L. M., & Green, D. R. (2012) · Cell · doi:10.1016/j.cell.2012.01.038 · Cited by 436 · see citing works
Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
Yang, D., Wang, X., Zhang, L., Fang, Y., Zheng, Q., Liu, X., Yu, W., Chen, S., Ying, J., & Hua, F. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00828-0 · Cited by 179 · see citing works
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Nutraceutical Properties of Chestnut Flours: Beneficial Effects on Skeletal Muscle Atrophy
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Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes
Tian, X., Rivera, E. K., Hwang, I., Nikitina, A. A., Smith, J. A., Cho, Y. J., Sala‐Jarque, J., DuBose, A., Andriola, C., Gollan‐Myers, T., et al. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70589 · Cited by 7 · see citing works
- Authors
- Bartke, N., & Hannun, Y. A.
- Affiliations
- Medical University of South Carolina (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 50
- Pages
- S91-S96
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC2674734
- OpenAlex
- W2096237954
- Cited by
- 683
- References
- 1
- Citations by year
- 2026: 20 · 2025: 32 · 2024: 27 · 2023: 32 · 2022: 44 · 2021: 55 · 2020: 47 · 2019: 52 · 2018: 46 · 2017: 30 · 2016: 31 · 2015: 47 · 2014: 30 · 2013: 39 · 2012: 46
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (GM43825)
- National Cancer Institute (R01CA087584, CA87584)
- National Institute of General Medical Sciences (GM-43825)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- sphingolipids, ceramide, sphingosine, sphingosine-1-phosphate, sphingolipid metabolism, cell growth, cell differentiation, senescence, apoptosis, subcellular compartmentalization, enzyme inducers
- MeSH terms
- Animals, Biological Transport, Esterases, Humans, Phospholipases, Sphingolipids, Lipid Metabolism
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