Cited by 292Advanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionAnalytical Chemistry and Sensors

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Optical biosensors: a decade in review

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Singh, Amit Kumar, Mittal, Shweta, Das, Mangal, Saharia, Ankur, Tiwari, Manish·2023·Alexandria Engineering Journal

DOI 10.1016/j.aej.2022.12.040

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Abstract

Miniaturized, specific, rapid response and economical biosensors are finding applications in biotechnology, environmental studies, agriculture, food inspection and safety, disease diagnosis and medical utilities. Of the many categories of biosensors, optical biosensors have brought about an extra edge in sensing applications due to their selective, rapid and extremely sensitive measurements. Biosensors are analytical tools used to detect specific analytes such as cholesterol, urea, etc. having biomolecules such as nucleic acids, proteins, carbohydrates as key element for detecting these analytes along with a transducer and a data analysis and visualization tool. In case of optical biosensors the analyte is detected using light with either label based or label free techniques. In this paper some of the marked advances in the last decade in the field of optical biosensors have been reviewed with an emphasis on their fabrication approaches and growing application areas. Along with some of the carefully selected article on new developments in optical biosensors through the last decade, a brief historical review of optical biosensors since the breakthrough in optical biosensors in 1970s has also been presented. Another focus of the current review is the classification of biosensors, typical structures along with emerging developments in optical biosensing that are likely to impact the current decade. Major application areas and emerging applications through the last decade have been outlined to present a clear picture on the versatility of optical biosensors. Finally, the review also considers the challenges and future of emerging optical biosensing technologies in the current decade.

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Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating
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Zinc oxide, gold and graphene-based surface plasmon resonance (SPR) biosensor for detection of pseudomonas like bacteria: A comparative study
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Ultrasensitive detection of SARS-CoV-2 nucleocapsid protein using large gold nanoparticle-enhanced surface plasmon resonance
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The Principle of Nanomaterials Based Surface Plasmon Resonance Biosensors and Its Potential for Dopamine Detection
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SPR-based plastic optical fibre biosensor for the detection of C-reactive protein in serum
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Porous Silicon-Based Biosensors: Towards Real-Time Optical Detection of Target Bacteria in the Food Industry
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A sensitive tapered-fiber optic biosensor for the label-free detection of organophosphate pesticides
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Recent advances in optical biosensors for the detection of cancer biomarker α-fetoprotein (AFP)
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A bead-based immunofluorescence-assay on a microfluidic dielectrophoresis platform for rapid dengue virus detection
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Evaluating the use of biosensors for monitoring of Penicillium digitatum infection in citrus fruit
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Flexible Transient Optical Waveguides and Surface‐Wave Biosensors Constructed from Monocrystalline Silicon
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Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects
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Label-free localized surface plasmon resonance biosensor composed of multi-functional DNA 3 way junction on hollow Au spike-like nanoparticles (HAuSN) for avian influenza virus detection
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A green and facile approach for synthesizing imine to develop optical biosensor for wide range detection of bilirubin in human biofluids
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Fluorometric virus detection platform using quantum dots-gold nanocomposites optimizing the linker length variation
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Photonic Crystals for Optical Sensing: A Review
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Rapid detection methods for Bacillus anthracis in environmental samples: a review
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Toward development of optical biosensors based on photoluminescence of TiO2 nanoparticles for the detection of Salmonella
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Experimental and theoretical investigation for surface plasmon resonance biosensor based on graphene/Au film/D-POF
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Monitoring thioredoxin redox with a genetically encoded red fluorescent biosensor
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Current Trends in the Biosensors for Biological Warfare Agents Assay
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Graphene oxide-based optical biosensor functionalized with peptides for explosive detection
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Nanobiosensors and fluorescence based biosensors: An overview
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Biosensor-based on-site explosives detection using aptamers as recognition elements
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Biosensors for medical applications
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A brief review on the strategy of developing SPR-based biosensors for application to the diagnosis of neglected tropical diseases
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Fluorescence-based biosensor for monitoring of environmental pollutants: From concept to field application
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Slow light Mach–Zehnder interferometer as label-free biosensor with scalable sensitivity
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An eco-designed paper-based algal biosensor for nanoformulated herbicide optical detection
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Optical Ring Resonators: A Platform for Biological Sensing Applications
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High sensitivity and ultra-compact optical biosensor for detection of UREA concentration
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Lighting Up Biosensors: Now and the Decade to Come
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Enhanced sandwich immunoassay using antibody-functionalized magnetic iron-oxide nanoparticles for extraction and detection of soluble transferrin receptor on a photonic crystal biosensor
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A sensitive fluorescent biosensor for the detection of copper ion inspired by biological recognition element pyoverdine
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Label-free detection of nosocomial bacteria using a nanophotonic interferometric biosensor
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Detection of antibody-antigen reaction by silicon nitride slot-ring biosensors using protein G
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Recent progress in optical and electrochemical biosensors for sensing of Clostridium botulinum neurotoxin
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Design and Optimization of SiON Ring Resonator-Based Biosensors for Aflatoxin M1 Detection
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Electrochemical and optical biosensors for early-stage cancer diagnosis by using graphene and graphene oxide
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Biosensors for Security and Bioterrorism Applications
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Fiber-Optic Biosensor to Detect pH and Glucose
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A sensitive surface-enhanced Raman scattering enzyme-catalyzed immunoassay of respiratory syncytial virus
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Design of highly sensitive multichannel bimetallic photonic crystal fiber biosensor
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Label-free detection of breast cancer biomarker using silica microfiber interferometry
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Surface plasmon resonance based photonic crystal fiber biosensors: A review
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Aptamer optical biosensor without bio-breakage using upconversion nanoparticles as donors
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Chemiluminescent Biosensors for Detection of Second Messenger Cyclic di-GMP
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Recent Progress in Surface Plasmon Resonance Biosensors (2016 to Mid-2018)
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A metal-organic zeolitic framework with immobilized urease for use in a tapered optical fiber urea biosensor
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A reusable optical biosensor for the ultrasensitive and selective detection of unamplified human genomic DNA with gold nanostars
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High-sensitivity and wide-range optical sensor based on three cascaded ring resonators
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Pedestal subwavelength grating metamaterial waveguide ring resonator for ultra-sensitive label-free biosensing
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A novel fluorescent “turn-on” aptasensor based on nitrogen-doped graphene quantum dots and hexagonal cobalt oxyhydroxide nanoflakes to detect tetracycline
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Low-Coherence Interferometric Fiber-Optic Sensors with Potential Applications as Biosensors
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SERS detection of hepatitis B virus DNA in a temperature‐responsive sandwich‐hybridization assay
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Plasmon-Enhanced Fluorescence in Coupled Nanostructures and Applications in DNA Detection
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Development and single laboratory validation of an optical biosensor assay for tetrodotoxin detection as a tool to combat emerging risks in European seafood
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The biosensor toolbox for plant developmental biology
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Interaction of Positively Charged Gold Nanoparticles with Cancer Cells Monitored by an in Situ Label-Free Optical Biosensor and Transmission Electron Microscopy
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Fabrication and Validation of a Handheld Non-Invasive, Optical Biosensor for Self-Monitoring of Glucose Using Saliva
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Development of a Cell-Free Optical Biosensor for Detection of a Broad Range of Mercury Contaminants in Water: A Plasmid DNA-Based Approach
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Optical biosensor optimized for continuous in-line glucose monitoring in animal cell culture
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Bienzymatic creatine biosensor based on reflectance measurement for real-time monitoring of fish freshness
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Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection
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MoSe2-Au Based Sensitivity Enhanced Optical Fiber Surface Plasmon Resonance Biosensor for Detection of Goat-Anti-Rabbit IgG
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Multiplex label-free biosensor for detection of autoantibodies in human serum: Tool for new kinetics-based diagnostics of autoimmune diseases
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Protein-binding aptamer assisted signal amplification for the detection of influenza A (H1N1) DNA sequences based on quantum dot fluorescence polarization analysis
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Future Perspective of Single-Molecule FRET Biosensors and Intravital FRET Microscopy
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Optical biosensor based on the microalga-paramecium symbiosis for improved marine monitoring
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Controlled fluorescence quenching by antibody-conjugated graphene oxide to measure tau protein
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Optofluidic microcapillary biosensor for label-free, low glucose concentration detection
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Optical Biomarker-based Biosensors for Cancer/Infectious Disease Medical Diagnoses
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Optical ATP biosensor for extracellular ATP measurement
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Fiber optic biosensor for detection of genetically modified food based on catalytic hairpin assembly reaction and nanocomposites assisted signal amplification
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A label-free fiber optic biosensor for Salmonella Typhimurium detection
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Vertically Coupled Plasmonic Racetrack Ring Resonator for Biosensor Applications
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One-step conjugation chemistry of DNA with highly scattered silver nanoparticles for sandwich detection of DNA
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Antibody conjugated green synthesized chitosan-gold nanoparticles for optical biosensing
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A novel optical biosensor for direct and selective determination of serotonin in serum by Solid Surface-Room Temperature Phosphorescence
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Development and validation of an optical biosensor for rapid monitoring of adalimumab in serum of patients with Crohn's disease
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Handheld Enzymatic Luminescent Biosensor for Rapid Detection of Heavy Metals in Water Samples
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Fiber optic biosensor for transdermal glucose based on the glucose binding protein
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Applications of Biosensors in Food Industry
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High-throughput living cell-based optical biosensor for detection of bacterial lipopolysaccharide (LPS) using a red fluorescent protein reporter system
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Highly-sensitive optical biosensor based on equal FSR cascaded microring resonator with intensity interrogation for detection of progesterone molecules
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An Optical Biosensor-Based Quantification of the Microcystin Synthetase A Gene: Early Warning of Toxic Cyanobacterial Blooming
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Microstructured optical fiber-based luminescent biosensing: Is there any light at the end of the tunnel? - A review
Pidenko, S. A., Burmistrova, N. A., Shuvalov, A. A., Chibrova, A. A., Skibina, J. S., & Goryacheva, I. Y. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.12.010 · Cited by 37
Long-Period Gratings and Microcavity In-Line Mach Zehnder Interferometers as Highly Sensitive Optical Fiber Platforms for Bacteria Sensing
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Label-free technology and patient cells: from early drug development to precision medicine
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Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma
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All-optical switching in dye-doped DNA nanofibers
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Simultaneous detection ofSalmonella enterica,Escherichia coliandListeria monocytogenesin food using a light scattering sensor
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An optical biosensor-based immunoassay for the determination of bovine serum albumin in milk and milk products
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Development of a new parallelized, optical biosensor platform for label-free detection of autoimmunity-related antibodies
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Fluorometric determination of HIV DNA using molybdenum disulfide nanosheets and exonuclease III-assisted amplification
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Flagged first, then by citations

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Research works printed but not linked: 6

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Sorted by citations

The emergence of AI-based wearable sensors for digital health technology: a review
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BackgroundMethodInfluential
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See all 292

Authors: Singh, A. K., Mittal, S., Das, M., Saharia, A., & Tiwari, M.
Affiliations: Manipal University Jaipur (IN)
Vellore Institute of Technology University (IN)
Corresponding author: Tiwari, Manish
ORCID: Singh, Amit Kumar
Das, Mangal
Saharia, Ankur
Venue: Alexandria Engineering Journal
Publisher: Elsevier BV
Published: 2023-03
Volume: 67
Pages: 673-691
ISSN: 1110-0168 (ISSN-L)
DOI: 10.1016/j.aej.2022.12.040
OpenAlex: W4320474624
Cited by: 292
References: 266
Citations by year: 2026: 64 · 2025: 108 · 2024: 87 · 2023: 33
FWCI: 26.02
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Alexandria Engineering Journal (publishedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
Keywords: optical biosensors, biosensor fabrication, label-free detection, biosensor classification, biosensor applications, biosensor miniaturization, disease diagnosis, food safety, environmental monitoring

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Optical biosensors: a decade in review

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