Lighting Up Biosensors: Now and the Decade to Come
Open accessAbstract
Optical biosensors are defined as portable optical devices that use biorecognition molecules to interrogate a sample for the presence of a target. The capabilities of optical biosensors have expanded rapidly with advances in miniature optical components and molecular engineering. Biosensors to meet the needs in health and environmental monitoring and food safety have become commercially available, with many more in the pipeline. We review the innovative approaches to overcoming existing hurdles to practical biosensor designs and explore potential areas for future breakthroughs in optical biosensor technology.
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Compared to electrochemical methods, optical biosensing can provide meaningful continuous monitoring with minimum fouling or signal drift depending on the materials and geometries.
“Compared to electrochemical methods, optical biosensing can provide meaningful continuous monitoring with minimum fouling or signal drift depending on the materials and geometries [179].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [179]
In electrochemical methods, biofouling occurs with electrodes, leading to decreased sensitivity for a specific analyte.
“In electrochemical methods, biofouling occurs with electrodes, leading to a decreased sensitivity for a specific analyte.”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [179]
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- Authors
- Ligler, F. S., & Gooding, J. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- UNSW Sydney (AU)
- Corresponding author
- Ligler, Frances S.
- Gooding, J. Justin
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-06-24
- Volume
- 91
- Issue
- 14
- Pages
- 8732-8738
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2953939449
- Cited by
- 70
- References
- 35
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 11 · 2023: 16 · 2022: 10 · 2021: 11 · 2020: 12
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- Funders
- Australian Research Council (FL150100060)
- Australian Research Council Centre of Excellence in Convergent Bio- Nano Science and Technology (CE14100036)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Keywords
- optical biosensors, biosensor development, health monitoring, environmental monitoring, food safety, molecular engineering
- MeSH terms
- Animals, Equipment Design, Humans, Biosensing Techniques, Optics and Photonics, Optical Devices
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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