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Cited by 32Blood transfusion and managementAcute Myocardial Infarction ResearchTrauma, Hemostasis, Coagulopathy, Resuscitation

Blood transfusion, bleeding, anemia, and survival in patients with acute myocardial infarction: FAST-MI registry

Ducrocq, Gregory, Puymirat, Etienne, Steg, Philippe Gabriel, Henry, Patrick, Martelet, Michel, Karam, Carma, Schiele, François, Simon, Tabassome +1 more·2015·American Heart Journal
DOI 10.1016/j.ahj.2015.07.004
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Abstract

Background An association between transfusion during index hospitalization and increased subsequent mortality has been reported in acute myocardial infarction (AMI). Whether this reflects the prognostic role of transfusion per se, or the impact of the index event leading to transfusion, remains unclear. We sought to evaluate the impact of transfusion on mortality in patients with AMI.Methods Using the nationwide FAST-MI 2005 AMI registry, we recorded anemia on admission, Thrombolysis in Myocardial Infarction major or minor bleeding, and transfusions during hospital stay. Multivariable analyses were performed to identify independent predictors of in-hospital and 5-year mortality. Cohorts of patients matched for propensity to receive transfusion were compared.Results Among 3541 patients with AMI, 827 (23.4%) had anemia on admission, 114 (3.2%) had minor or major bleeding, and 151 (4.3%) underwent transfusion. After multivariable analysis, both anemia and bleeding were independently associated with 5-year mortality (hazard ratio [HR] 1.4, 95% CI 1.2-1.6 and HR 1.4, 95% CI 1.1-1.8, respectively), whereas transfusion did not appear to be an independent predictor (HR 1.1, 95% CI 0.8-1.5). Mortality at 5 years did not differ between cohorts matched for propensity to receive transfusion.Conclusions In this cohort, anemia on admission and bleeding during hospitalization were both associated with increased 5-year mortality in patients with myocardial infarction. Conversely, transfusion per se was not associated with lower survival. Further work is needed to clarify the optimal transfusion strategy in patients with bleeding or anemia and myocardial infarction.

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Crossref · 10.1016/j.ahj.2015.07.004

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  • Therapeutic interventions aimed to increase the circulating number of RBCs (transfusion of blood or administration of erythropoiesis-stimulating agents) were not always effective in the tested cohorts.

    “However, therapeutic interventions aimed to increase the circulating number of RBCs (e.g., by transfusion of blood or by administration of erythropoiesis-stimulating agents [ESAs] to stimulate the production of RBCs by the bone marrow), were not always effective in the tested cohorts (48, 91, 156).”

    From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [48]

  • Big cohort/epidemiological studies show associations between anemia and cardiovascular complications.

    “Interestingly, there are big cohort/epidemiological studies showing associations between anemia and cardiovascular complications (48, 87, 91).”

    From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [48]

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Authors
Ducrocq, G., Puymirat, E., Steg, P. G., Henry, P., Martelet, M., Karam, C., Schiele, F., Simon, T., & Danchin, N.
Affiliations
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Hôpital Ambroise-Paré (FR)
  • Centre Hospitalier Universitaire de Besançon (FR)
  • Hôpital Européen Georges-Pompidou (FR)
ORCID
Venue
American Heart Journal
Publisher
Elsevier BV
Published
2015-10
Volume
170
Issue
4
Pages
726-734.e2
ISSN
0002-8703 (ISSN-L)
DOI
10.1016/j.ahj.2015.07.004
OpenAlex
W2168779253
Cited by
32
References
24
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 5
FWCI
2.74
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Pfizer
  • Servier
Topics
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
acute myocardial infarction, blood transfusion, anemia, hemorrhage, mortality, long-term survival, in-hospital mortality, prognostic factors, FAST-MI registry
MeSH terms
Aged, Anemia, Blood Transfusion, Female, Follow-Up Studies, France, Hemorrhage, Humans, Male, Middle Aged, Myocardial Infarction, Registries, Retrospective Studies, Risk Factors, Incidence, Survival Rate, Risk Assessment

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