The role of adropin, HIF-1α and apelin biomarkers in the diagnosis of acute mesentaric ischemia
Abstract
Objective The absence of a specific biomarker for acute mesenteric ischemia diagnosis results in a delay in diagnosis and treatment, as well as a high mortality rate. The current research examined whether the proteins adropin, HIF-1α, and apelin may be used to help in the early detection of acute mesenteric ischemia.Materials and methods A total of 20 patients with acute mesenteric ischemia, 20 patients with abdominal pain, and 20 healthy controls were included in the study. The levels of adropin, HIF-1, and apelin in the serum were determined using the ELISA method.Results Adropin concentrations were significantly higher in the acute mesenteric ischemia group than in the abdominal pain and healthy control groups (p < 0.05). HIF-1α levels were considerably greater in patients with acute mesenteric ischemia compared to both the abdominal pain group and the healthy control group (p < 0.05). There was no difference in apelin levels between the acute mesenteric ischemia and abdominal pain groups (p > 0.05). HIF-1α was found to be moderate (AUC: 0.705) and adropin was found to be a weak biomarker (AUC: 0.692) in the ROC analysis for acute mesenteric ischemia.Conclusion In this study of 20 patients with acute mesenteric ischemia, we found adropin and HIF-1α levels to be increased compared to patients with abdominal pain who did not have acute mesenteric ischemia.
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Serum adropin had sensitivity 65% and specificity 70% in a single study.
“Serum adropin (65 and 70%) [91].”
From Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis (2023) · cites this paper as [91]
Serum hypoxia-induced factor alpha had sensitivity 75% and specificity 70% in a single study.
“Serum hypoxia-induced factor alpha (HIF1-α) (75 and 70%) [91].”
From Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis (2023) · cites this paper as [91]
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- Authors
- Kurt, E., Tekin, E., Kurt, N., & Bayramoglu, A.
- Affiliations
- Erzincan Mengücek Gazi Eğitim ve Araştırma Hastanesi (TR)
- Atatürk University (TR)
- Erzincan Binali Yıldırım University (TR)
- Corresponding author
- Kurt, Nezahat
- Venue
- The American Journal of Emergency Medicine
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 51
- Pages
- 223-227
- ISSN
- 0735-6757 (ISSN-L)
- OpenAlex
- W3208936736
- Cited by
- 13
- References
- 32
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 2
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The American Journal of Emergency Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ataturk University
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- acute mesenteric ischemia, adropin, HIF-1α, apelin, serum biomarkers, early diagnosis, abdominal pain, diagnostic accuracy
- MeSH terms
- Apelin, Aged, Aged, 80 and over, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, ROC Curve, Biomarkers, Abdominal Pain, Case-Control Studies, Intercellular Signaling Peptides and Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, Mesenteric Ischemia
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