Cited by 96Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and Animals

Population structure can inflate SNP-based heritability estimates

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Browning, Sharon R., Browning, Brian L.·2011·The American Journal of Human Genetics

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Crossref · 10.1016/j.ajhg.2011.05.025

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8 of 8 references verified0 citation errors · 0 not checkable

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  • The top four genetic PCs were included as covariates in the model to correct for population structure, which can inflate heritability estimates.

    “The top four genetic PCs were included as covariates in the model to correct for population structure, which can inflate heritability estimates [18,69,70].”
  • The genetic relationship matrix based on allele sharing is inflated by population structure; in addition, pilot studies observed a large sampling variability of GCTA-estimated heritability due to the moderate size of the Cape Verde sample.

    “However, the genetic relationship matrix based on allele sharing is inflated by population structure [55]; in addition, in pilot studies we observed a large sampling variability of GCTA-estimated heritability due to the moderate size of the Cape Verde sample.”

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Authors
Browning, S. R., & Browning, B. L.
Affiliations
University of Washington (US)
Corresponding author
Browning, Sharon R.
Venue
The American Journal of Human Genetics
Publisher
Elsevier BV
Published
2011-07
Volume
89
Issue
1
Pages
191-193
ISSN
0002-9297 (ISSN-L)
OpenAlex
W2033351168
Cited by
96
References
9
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 8 · 2021: 6 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 12 · 2012: 8
Type
journal article
Language
en
Open access
Locations
  • The American Journal of Human Genetics (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust (076113)
  • National Institutes of Health
  • National Human Genome Research Institute (R01HG005701, R01HG004960)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords
missing heritability, population structure, common SNPs, heritability estimation, genome-wide association study, Crohn's disease, bipolar disorder, type 1 diabetes, Wellcome Trust Case Control Consortium, European ancestry, population stratification
MeSH terms
Bipolar Disorder, Computer Simulation, Crohn Disease, Diabetes Mellitus, Type 1, Genetics, Population, Genotype, Geography, United Kingdom, Humans, Models, Genetic, Phenotype, Software, Quantitative Trait, Heritable, Polymorphism, Single Nucleotide, White People

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