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Use of antidepressant medications during pregnancy: a multisite study
Abstract
Objective This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States.Study design A retrospective study was conducted using the automated databases of 7 health plans. Women who delivered an infant in a hospital were identified. Antidepressant drug use was evaluated assuming a gestational duration of 270 days.Results Among the 118,935 deliveries occurring from 2001-2005, 6.6% of women were dispensed an antidepressant during pregnancy. Antidepressant drug use increased from 2.0% in 1996 to 7.6% of deliveries in 2004 and 2005. Selective serotonin reuptake inhibitor use increased from 1.5% in 1996 to 6.4% in 2004 and 6.2% in 2005.Conclusion Our finding that nearly 8% of pregnant women were prescribed antidepressants drugs during the years 2004 and 2005 highlights the importance of understanding the effects of these medications on the developing fetus and on the pregnant woman.
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“Although pharmacological treatment is effective and can be safely utilized during pregnancy under medical supervision, only 2–8% of pregnant women are currently estimated to use antidepressants (23–26).”
From Acceptance, experiences, and needs of hospitalized pregnant women toward an electronic mindfulness-based intervention: A pilot mixed-methods study (2022) · cites this paper as [23]
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Metadata
- Authors
- Andrade, S. E., Raebel, M. A., Brown, J., Lane, K., Livingston, J., Boudreau, D., Rolnick, S. J., Roblin, D., Smith, D. H., Willy, M. E., Staffa, J. A., & Platt, R.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Kaiser Permanente (US)
- Harvard University (US)
- Group Health Cooperative (US)
- HealthPartners (US)
- United States Food and Drug Administration (US)
- Corresponding author
- Andrade, Susan E.
- ORCID
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 198
- Issue
- 2
- Pages
- 194.e1-194.e5
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2063638540
- Cited by
- 403
- References
- 18
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 17 · 2021: 9 · 2020: 24 · 2019: 24 · 2018: 24 · 2017: 27 · 2016: 38 · 2015: 37 · 2014: 28 · 2013: 43 · 2012: 39
- FWCI
- 15.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- antidepressant use in pregnancy, selective serotonin reuptake inhibitors, maternal mental health, prenatal drug exposure, health insurance claims
- MeSH terms
- Adolescent, Adult, Antidepressive Agents, Depressive Disorder, Female, Health Maintenance Organizations, Humans, Infant, Newborn, Middle Aged, Practice Patterns, Physicians', Pregnancy, Pregnancy Complications, Prenatal Care, Retrospective Studies, United States, Databases, Factual, Selective Serotonin Reuptake Inhibitors, Drug Utilization Review
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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