Biophysical profile in the treatment of intrauterine growth-restricted fetuses who weigh <1000 g
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Objective The aim of this study was to determine the biophysical profile (BPP) usefulness in the prediction of cord pH, base excess, and guidance regarding the timing of delivery in preterm intrauterine growth-restricted (IUGR) fetuses.Study design A BPP was performed daily in 48 IUGR fetuses and was considered abnormal when it was 2/10 on 1 single occasion or 4/10 on 2 consecutive occasions 2 hours apart.Results The median gestational age and fetal weight for the total population was 27.6 weeks and 632 g, respectively. In 13 fetuses with a BPP of 6, there were 3 deaths, and 7 fetuses were acidemic. In 27 fetuses with a BPP of 8, there were 3 deaths, and 12 fetuses were acidemic.Conclusion BPP alone is not a reliable test in the treatment of preterm IUGR fetuses, because of high false-positive and -negative results. The common notion of a good BPP providing reassurance for at least 24 hours is not applicable in severely preterm IUGR fetuses who weigh <1000 g.
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A Cochrane review concluded that available evidence from randomized controlled trials does not support the use of BPP as a test of fetal well-being in high-risk pregnancies.
“A Cochrane review concluded that available evidence from randomized controlled trials does not support the use of BPP as a test of fetal well-being in high-risk pregnancies.153,154”
From Society for Maternal-Fetal Medicine Consult Series #52: Diagnosis and management of fetal growth restriction (2020) · cites this paper as [154]
The COMMENT and SMFM Papers sections conclude that BPP alone is unreliable for predicting fetal well-being in severely preterm, growth-restricted fetuses. The paper does not report a Cochrane review or a conclusion from randomized controlled trials, and its findings do not cover high-risk pregnancies generally. Page numbers are unavailable in our copy. (LLM, conf=0.85)
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Self-citation
- Authors
- Kaur, S., Picconi, J. L., Chadha, R., Kruger, M., & Mari, G.
- Affiliations
- Wayne State University (US)
- University of Tennessee Health Science Center (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 199
- Issue
- 3
- Pages
- 264.e1-264.e4
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2060718707
- Semantic Scholar
- cbda4bfd61319569e2df81786be8d1b171683592
- Cited by
- 46
- References
- 11
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2014: 10 · 2013: 3 · 2012: 1
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- fetal biophysical profile, fetal growth restriction, fetal acidemia, cord blood pH, base excess, fetal acid-base status, timing of delivery, fetal monitoring, false positives and false negatives
- MeSH terms
- Acid-Base Equilibrium, Biophysics, Blood Flow Velocity, Blood Gas Analysis, Female, Fetal Growth Retardation, Gestational Age, Humans, Male, Predictive Value of Tests, Pregnancy, Regional Blood Flow, Umbilical Arteries, Ultrasonography, Prenatal, Ultrasonography, Doppler, Fetal Weight, Biophysical Phenomena
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